Effects of repetitive transcranial magnetic stimulation on clinical, social, and cognitive performance in postpartum depression

• Autor(a) principal: Myczkowski, Martin Luiz
• Data de Publicação: 2012
• Outros Autores: Dias, Alvaro Machado [UNIFESP], Luvisotto, Tatiana, Arnaut, Debora, Bellini, Bianca Boura, Mansur, Carlos Gustavo, Renno, Joel, Tortella, Gabriel, Ribeiro, Philip Leite, Marcolin, Marco Antonio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.2147/NDT.S33851; http://repositorio.unifesp.br/handle/11600/34395
• topic: transcranial magnetic stimulation; postpartum depression; clinical performance; cognitive performance; social performance

Background: This randomized, placebo-controlled, double-blind pilot study evaluated the impact of repetitive transcranial magnetic stimulation (rTMS) on clinical, cognitive, and social performance in women suffering with postpartum depression.Methods: Fourteen patients were randomized to receive 20 sessions of sham rTMS or active 5 Hz rTMS over the left dorsolateral prefrontal cortex. Psychiatric clinical scales and a neuropsychological battery were applied at baseline (pretreatment), week 4 (end of treatment), and week 6 (follow-up, posttreatment week 2).Results: the active rTMS group showed significant improvement 2 weeks after the end of rTMS treatment (week 6) in Hamilton Depression Rating Scale (P = 0.020), Global Assessment Scale (P = 0.037), Clinical Global Impression (P = 0.047), and Social Adjustment Scale-Self Report-Work at Home (P = 0.020).Conclusion: This study suggests that rTMS has the potential to improve the clinical condition in postpartum depression, while producing marginal gains in social and cognitive function.