Carcinoma de paratiróide: características clínicas e anátomo-patológicas de cinco casos

• Autor(a) principal: Morimitsu, Lilian K. [UNIFESP]
• Data de Publicação: 2001
• Outros Autores: Uyeno, Monique N.o. [UNIFESP], Goulart, Marcio L. [UNIFESP], Hauache, Omar M. [UNIFESP], Vieira, José Gilberto H. [UNIFESP], Alberti, Vânia N. [UNIFESP], Abrahão, Márcio [UNIFESP], Cervantes, Onivaldo [UNIFESP], Lazaretti-Castro, Marise [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-27302001000200006; http://repositorio.unifesp.br/handle/11600/1147
• topic: Parathyroid carcinoma; Primary hiperparathyroidism; Hypercalcemia; PTH; Hiperparatiroidismo primário; Carcinoma de paratiróide; Hipercalcemia; PTH

Parathyroid carcinoma is a rare disease, with about 535 cases reported in the literature until now. In this paper, we reviewed 5 cases of parathyroid carcinoma followed at Universidade Federal de São Paulo (UNIFESP) from 1983 to 1998, and discuss aspects of clinical presentation, diagnosis and treatment. Four patients were female and 1 male, with median ages of 52 years (10 to 77 years). Initial clinical complains were bone pain and weight loss in 4 patients, traumatic fracture in 2, and fracture without trauma in 3. Kidney stone was present in 1 patient. All had a palpable mass in the cervical region and presented with high calcium levels: 14.9±1.7mg/dL (mean±SD). Parathyroid hormone (PTH) levels were extremely high, showing the severity of the disease. All patients had surgical exploration where a tumor mass was recognized and removed. Pathologic examination demonstrated parathyroid carcinoma in all. On follow-up, 2 patients had recurrence and died due to complications of hyperparathyroidism. To date, the other 3 patients have no evidences of recurrence.