Acai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis

• Autor(a) principal: Fragoso, Mariana F.
• Data de Publicação: 2013
• Outros Autores: Romualdo, Guilherme R., Ribeiro, Daniel Araki [UNIFESP], Barbisan, Luis F.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1016/j.fct.2013.04.011; http://repositorio.unifesp.br/handle/11600/36558
• topic: Aberrant crypt foci; Spray-dry; Acai pulp; Colon carcinogenesis

This study investigated the protective effect of spray-dried gal powder (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH administrations, the groups were fed with standard diet, a diet containing 2.5% or 5.0% AP or a diet containing 0.2% N-acetylcysteine (NAC) for 10 weeks, using aberrant crypt foci (ACF) as the endpoint. Additionally, two groups were fed with standard diet or a diet containing 5.0% AP for 20 weeks, using colon tumors as the endpoint. in ACF assay, a reduction in the number of aberrant crypts (ACs) and ACF (1 similar to 3 AC) were observed in the groups fed with 5.0% AP (37% AC and 47% ACF inhibition, p = 0.036) and 0.2% NAC (39% AC and 41% ACF inhibition, p = 0.042). in tumor assay, a reduction in the number of invasive tumors (p < 0.005) and tumor multiplicity (p = 0.001) was observed in the group fed with 5.0% AP. Also, a reduction in tumor Ki-67 cell proliferation (p = 0.003) and net growth index (p = 0.001) was observed in the group fed with 5.0% AP. Therefore the findings of this study indicate that AP feeding may reduce the development of chemically-induced rat colon carcinogenesis. (C) 2013 Elsevier B.V. All rights reserved.