Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

Detalhes bibliográficos
Autor(a) principal: Carlin, Viviane [UNIFESP]
Data de Publicação: 2010
Outros Autores: Artioli, A. J., Matsumoto, M. A., Filho, H. N., Borgo, E., Oshima, Celina Tizuko Fujiyama [UNIFESP], Ribeiro, Daniel Araki [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1259/dmfr/17573156
http://repositorio.unifesp.br/handle/11600/32654
Resumo: Objectives: the aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure.Methods: A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included.Results: No significant statistically differences (P > 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. in contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P < 0.05).Conclusion: in summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 295-299. doi: 10.1259/dmfr/17573156
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spelling Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomographybuccal mucosa cellscone beam computed tomographymicronucleus testObjectives: the aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure.Methods: A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included.Results: No significant statistically differences (P > 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. in contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P < 0.05).Conclusion: in summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 295-299. doi: 10.1259/dmfr/17573156Universidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, SP, BrazilUniversidade Federal de São Paulo, Paulista Med Sch, Dept Pathol, BR-11060001 Santos, SP, BrazilSagrado Coracao Univ, Discipline Oral & Maxillofacial Surg, Dept Hlth Sci, São Paulo, BrazilPI Branemark Inst, Bauru, SP, BrazilUniversidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, SP, BrazilUniversidade Federal de São Paulo, Paulista Med Sch, Dept Pathol, BR-11060001 Santos, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP: 07/00345-7FAPESP: 07/01228-4British Inst RadiologyUniversidade Federal de São Paulo (UNIFESP)Sagrado Coracao UnivUniversidade de São Paulo (USP)Carlin, Viviane [UNIFESP]Artioli, A. J.Matsumoto, M. A.Filho, H. N.Borgo, E.Oshima, Celina Tizuko Fujiyama [UNIFESP]Ribeiro, Daniel Araki [UNIFESP]2016-01-24T14:05:05Z2016-01-24T14:05:05Z2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion295-299http://dx.doi.org/10.1259/dmfr/17573156Dentomaxillofacial Radiology. London: British Inst Radiology, v. 39, n. 5, p. 295-299, 2010.10.1259/dmfr/175731560250-832Xhttp://repositorio.unifesp.br/handle/11600/32654WOS:000279343500007engDentomaxillofacial Radiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-10-10T13:38:33Zoai:repositorio.unifesp.br/:11600/32654Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-10-10T13:38:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
title Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
spellingShingle Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
Carlin, Viviane [UNIFESP]
buccal mucosa cells
cone beam computed tomography
micronucleus test
title_short Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
title_full Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
title_fullStr Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
title_full_unstemmed Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
title_sort Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
author Carlin, Viviane [UNIFESP]
author_facet Carlin, Viviane [UNIFESP]
Artioli, A. J.
Matsumoto, M. A.
Filho, H. N.
Borgo, E.
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
author_role author
author2 Artioli, A. J.
Matsumoto, M. A.
Filho, H. N.
Borgo, E.
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Sagrado Coracao Univ
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Carlin, Viviane [UNIFESP]
Artioli, A. J.
Matsumoto, M. A.
Filho, H. N.
Borgo, E.
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
dc.subject.por.fl_str_mv buccal mucosa cells
cone beam computed tomography
micronucleus test
topic buccal mucosa cells
cone beam computed tomography
micronucleus test
description Objectives: the aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure.Methods: A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included.Results: No significant statistically differences (P > 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. in contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P < 0.05).Conclusion: in summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 295-299. doi: 10.1259/dmfr/17573156
publishDate 2010
dc.date.none.fl_str_mv 2010-07-01
2016-01-24T14:05:05Z
2016-01-24T14:05:05Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1259/dmfr/17573156
Dentomaxillofacial Radiology. London: British Inst Radiology, v. 39, n. 5, p. 295-299, 2010.
10.1259/dmfr/17573156
0250-832X
http://repositorio.unifesp.br/handle/11600/32654
WOS:000279343500007
url http://dx.doi.org/10.1259/dmfr/17573156
http://repositorio.unifesp.br/handle/11600/32654
identifier_str_mv Dentomaxillofacial Radiology. London: British Inst Radiology, v. 39, n. 5, p. 295-299, 2010.
10.1259/dmfr/17573156
0250-832X
WOS:000279343500007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dentomaxillofacial Radiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 295-299
dc.publisher.none.fl_str_mv British Inst Radiology
publisher.none.fl_str_mv British Inst Radiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268450524102656

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