CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION

Detalhes bibliográficos
Autor(a) principal: de Oliveira Dias, Joao Rafael [UNIFESP]
Data de Publicação: 2017
Outros Autores: de Andrade, Gabriel Costa [UNIFESP], Kniggendorf, Vinicius Ferreira [UNIFESP], Novais, Eduardo Amorim [UNIFESP], Maia, Andre [UNIFESP], Meyer, Carsten [UNIFESP], Watanabe, Sung Eun Song [UNIFESP], Farah, Michel Eid [UNIFESP], Rodrigues, Eduardo Buschele [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1097/IAE.0000000000001385
http://repositorio.unifesp.br/handle/11600/51479
Resumo: Purpose: To evaluate the 6-month safety and efficacy of ziv-aflibercept intravitreal injections for treating exudative age-related macular degeneration. Methods: Fifteen patients with unilateral exudative age-related macular degeneration were enrolled. The best-corrected visual acuity was measured and spectral domain optical coherence tomography was performed at baseline and monthly. Full-field electroretinography and multifocal electroretinography were obtained at baseline and 4, 13, and 26 weeks after the first injection. All patients received three monthly intravitreal injections of ziv-aflibercept (1.25 mg) followed by as-needed treatment. Results: Between baseline and 26 weeks, the mean logMAR best-corrected visual acuity improved (P = 0.00408) from 0.93 +/- 0.4 (20/200) to 0.82 +/- 0.5 (20/160) logarithm of the minimum angle of resolution, respectively
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spelling CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATIONziv-afliberceptage-related macular degenerationfull-field electroretinographymultifocal electroretinographyPurpose: To evaluate the 6-month safety and efficacy of ziv-aflibercept intravitreal injections for treating exudative age-related macular degeneration. Methods: Fifteen patients with unilateral exudative age-related macular degeneration were enrolled. The best-corrected visual acuity was measured and spectral domain optical coherence tomography was performed at baseline and monthly. Full-field electroretinography and multifocal electroretinography were obtained at baseline and 4, 13, and 26 weeks after the first injection. All patients received three monthly intravitreal injections of ziv-aflibercept (1.25 mg) followed by as-needed treatment. Results: Between baseline and 26 weeks, the mean logMAR best-corrected visual acuity improved (P = 0.00408) from 0.93 +/- 0.4 (20/200) to 0.82 +/- 0.5 (20/160) logarithm of the minimum angle of resolution, respectivelythe central retinal thickness decreased significantly (P = 0.0007) from 490.3 +/- 155.1 microns to 327.9 +/- 101.5 micronsthe mean total macular volume decreased significantly (P < 0.0001) from 9.51 +/- 1.36 mm(3) to 8.08 +/- 1.34 mm(3), and the a-wave implicit time increased, with no differences in the other full-field electroretinography parameters. The average multifocal electroretinography macular responses within the first central 15 degrees showed significantly (P < 0.05) increased P-1 amplitudes at 26 weeks. No systemic or ocular complications developed. Conclusion: Intravitreal ziv-aflibercept significantly improved the best-corrected visual acuity, multifocal electroretinography amplitudes, central retinal thickness, and total macular volume from baseline to 26 weeks. No retinal toxicity on full-field electroretinography or adverse events occurred during the follow-up period.Univ Fed São Paulo, Paulista Med Sch, Dept Ophthalmol, Rua Botucatu 821,1st Floor, BR-04023062 São Paulo, BrazilUniv Fed São Paulo, Paulista Med Sch, Dept Ophthalmol, Rua Botucatu 821,1st Floor, BR-04023062 São Paulo, BrazilWeb of ScienceFundação de Amparo a Pesquisa do Estado de São Paulo (São Paulo, Brazil)Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasilia, Brazil)Pan-American Association of Ophthalmology/Pan-American Ophthalmological Foundation, Paul Kayser Global Award, Arlington, TXLippincott Williams & Wilkins2019-08-19T11:50:07Z2019-08-19T11:50:07Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1499-1507application/pdfhttp://dx.doi.org/10.1097/IAE.0000000000001385Retina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 37, n. 8, p. 1499-1507, 2017.10.1097/IAE.0000000000001385WOS000406108700010.pdf0275-004Xhttp://repositorio.unifesp.br/handle/11600/51479WOS:000406108700010enginfo:eu-repo/semantics/openAccessde Oliveira Dias, Joao Rafael [UNIFESP]de Andrade, Gabriel Costa [UNIFESP]Kniggendorf, Vinicius Ferreira [UNIFESP]Novais, Eduardo Amorim [UNIFESP]Maia, Andre [UNIFESP]Meyer, Carsten [UNIFESP]Watanabe, Sung Eun Song [UNIFESP]Farah, Michel Eid [UNIFESP]Rodrigues, Eduardo Buschele [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T02:43:15Zoai:repositorio.unifesp.br/:11600/51479Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T02:43:15Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
title CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
spellingShingle CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
de Oliveira Dias, Joao Rafael [UNIFESP]
ziv-aflibercept
age-related macular degeneration
full-field electroretinography
multifocal electroretinography
title_short CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
title_full CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
title_fullStr CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
title_full_unstemmed CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
title_sort CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
author de Oliveira Dias, Joao Rafael [UNIFESP]
author_facet de Oliveira Dias, Joao Rafael [UNIFESP]
de Andrade, Gabriel Costa [UNIFESP]
Kniggendorf, Vinicius Ferreira [UNIFESP]
Novais, Eduardo Amorim [UNIFESP]
Maia, Andre [UNIFESP]
Meyer, Carsten [UNIFESP]
Watanabe, Sung Eun Song [UNIFESP]
Farah, Michel Eid [UNIFESP]
Rodrigues, Eduardo Buschele [UNIFESP]
author_role author
author2 de Andrade, Gabriel Costa [UNIFESP]
Kniggendorf, Vinicius Ferreira [UNIFESP]
Novais, Eduardo Amorim [UNIFESP]
Maia, Andre [UNIFESP]
Meyer, Carsten [UNIFESP]
Watanabe, Sung Eun Song [UNIFESP]
Farah, Michel Eid [UNIFESP]
Rodrigues, Eduardo Buschele [UNIFESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv de Oliveira Dias, Joao Rafael [UNIFESP]
de Andrade, Gabriel Costa [UNIFESP]
Kniggendorf, Vinicius Ferreira [UNIFESP]
Novais, Eduardo Amorim [UNIFESP]
Maia, Andre [UNIFESP]
Meyer, Carsten [UNIFESP]
Watanabe, Sung Eun Song [UNIFESP]
Farah, Michel Eid [UNIFESP]
Rodrigues, Eduardo Buschele [UNIFESP]
dc.subject.por.fl_str_mv ziv-aflibercept
age-related macular degeneration
full-field electroretinography
multifocal electroretinography
topic ziv-aflibercept
age-related macular degeneration
full-field electroretinography
multifocal electroretinography
description Purpose: To evaluate the 6-month safety and efficacy of ziv-aflibercept intravitreal injections for treating exudative age-related macular degeneration. Methods: Fifteen patients with unilateral exudative age-related macular degeneration were enrolled. The best-corrected visual acuity was measured and spectral domain optical coherence tomography was performed at baseline and monthly. Full-field electroretinography and multifocal electroretinography were obtained at baseline and 4, 13, and 26 weeks after the first injection. All patients received three monthly intravitreal injections of ziv-aflibercept (1.25 mg) followed by as-needed treatment. Results: Between baseline and 26 weeks, the mean logMAR best-corrected visual acuity improved (P = 0.00408) from 0.93 +/- 0.4 (20/200) to 0.82 +/- 0.5 (20/160) logarithm of the minimum angle of resolution, respectively
publishDate 2017
dc.date.none.fl_str_mv 2017
2019-08-19T11:50:07Z
2019-08-19T11:50:07Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1097/IAE.0000000000001385
Retina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 37, n. 8, p. 1499-1507, 2017.
10.1097/IAE.0000000000001385
WOS000406108700010.pdf
0275-004X
http://repositorio.unifesp.br/handle/11600/51479
WOS:000406108700010
url http://dx.doi.org/10.1097/IAE.0000000000001385
http://repositorio.unifesp.br/handle/11600/51479
identifier_str_mv Retina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 37, n. 8, p. 1499-1507, 2017.
10.1097/IAE.0000000000001385
WOS000406108700010.pdf
0275-004X
WOS:000406108700010
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1499-1507
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268366541553664

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