Espectroscopia por ressonância magnética no diagnóstico do câncer de próstata: experiência inicial

• Autor(a) principal: Melo, Homero José de Farias e [UNIFESP]
• Data de Publicação: 2009
• Outros Autores: Szejnfeld, Denis [UNIFESP], Paiva, Cristiano Silveira, Abdala, Nitamar [UNIFESP], Arruda, Homero Oliveira de [UNIFESP], Goldman, Suzan Menasce [UNIFESP], Szejnfeld, Jacob [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0100-39842009000100003; http://repositorio.unifesp.br/handle/11600/4888
• topic: Magnetic resonance spectroscopy imaging; Prostate; Prostatic neoplasm; Espectroscopia por ressonância magnética; Próstata; Neoplasia prostática

OBJECTIVE: To report an experiment involving the introduction of a protocol utilizing commercially available three-dimensional 1H magnetic resonance spectroscopy imaging (3D 1H MRSI) method in patients diagnosed with prostatic tumors under suspicion of neoplasm. MATERIALS AND METHODS: Forty-one patients in the age range between 51 and 80 years (mean, 67 years) were prospectively evaluated. The patients were divided into two groups: patients with one or more biopsies negative for cancer and high specific-prostatic antigen levels (group A), and patients with cancer confirmed by biopsy (group B). The determination of the target-area (group A) or the known cancer extent (group B) was based on magnetic resonance imaging and MRSI studies. RESULTS: The specificity of MRSI in the diagnosis of prostate cancer was lower than the specificity reported in the literature (about 47%). On the other hand, for tumor staging, it corresponded to the specificity reported in the literature. CONCLUSION: The introduction and standardization of 3D 1H MRSI has allowed the obtention of a presumable diagnosis of prostate cancer, by a combined analysis of magnetic resonance imaging and metabolic data from 3D 1H MRSI.