Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/0013000011093 |
Texto Completo: | http://dx.doi.org/10.1590/S1807-59322009001200008 http://repositorio.unifesp.br/handle/11600/4836 |
Resumo: | OBJECTIVES: The aim of the present study was to investigate the effectiveness of Samarium153-particulate hydroxyapatite radiation synovectomy in rheumatoid arthritis patients with chronic knee synovitis. METHODS: Fifty-eight rheumatoid arthritis patients (60 knees) with chronic knee synovitis participated in a controlled double-blinded trial. Patients were randomized to receive either an intra-articular injection with 40 mg triamcinolone hexacetonide alone (TH group) or 40 mg triamcinolone hexacetonide combined with 15 mCi Samarium153-particulate hydroxyapatite (Sm/TH group). Blinded examination at baseline (T0) and at 1 (T1), 4 (T4), 12 (T12), 32 (T32), and 48 (T48) weeks post-intervention were performed on all patients and included a visual analog scale for joint pain and swelling as well as data on morning stiffness, flexion, extension, knee circumference, Likert scale of improvement, percentage of improvement, SF-36 generic quality of life questionnaire, Stanford Health Assessment Questionnaire (HAQ), Lequesne index, use of non-steroidal anti-inflammatory drugs or oral corticosteroids, events and adverse effects, calls to the physician, and hospital visits. RESULTS: The sample was homogeneous at baseline, and there were no withdrawals. Improvement was observed in both groups in relation to T0, but no statistically significant differences between groups were observed regarding all variables at the time points studied. The Sm/TH group exhibited more adverse effects at T1 (p<0.05), but these were mild and transitory. No severe adverse effects were reported during follow-up. CONCLUSION: Intra-articular injection of Samarium153-particulate hydroxyapatite (15 mCi) with 40 mg of triamcinolone hexacetonide is not superior to triamcinolone hexacetonide alone for the treatment of knee synovitis in patients with rheumatoid arthritis at 1 y of follow-up. |
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Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trialRheumatoid arthritisIntra-articular injectionRadiosynoviorthesisRadiation synovectomySamariumOBJECTIVES: The aim of the present study was to investigate the effectiveness of Samarium153-particulate hydroxyapatite radiation synovectomy in rheumatoid arthritis patients with chronic knee synovitis. METHODS: Fifty-eight rheumatoid arthritis patients (60 knees) with chronic knee synovitis participated in a controlled double-blinded trial. Patients were randomized to receive either an intra-articular injection with 40 mg triamcinolone hexacetonide alone (TH group) or 40 mg triamcinolone hexacetonide combined with 15 mCi Samarium153-particulate hydroxyapatite (Sm/TH group). Blinded examination at baseline (T0) and at 1 (T1), 4 (T4), 12 (T12), 32 (T32), and 48 (T48) weeks post-intervention were performed on all patients and included a visual analog scale for joint pain and swelling as well as data on morning stiffness, flexion, extension, knee circumference, Likert scale of improvement, percentage of improvement, SF-36 generic quality of life questionnaire, Stanford Health Assessment Questionnaire (HAQ), Lequesne index, use of non-steroidal anti-inflammatory drugs or oral corticosteroids, events and adverse effects, calls to the physician, and hospital visits. RESULTS: The sample was homogeneous at baseline, and there were no withdrawals. Improvement was observed in both groups in relation to T0, but no statistically significant differences between groups were observed regarding all variables at the time points studied. The Sm/TH group exhibited more adverse effects at T1 (p<0.05), but these were mild and transitory. No severe adverse effects were reported during follow-up. CONCLUSION: Intra-articular injection of Samarium153-particulate hydroxyapatite (15 mCi) with 40 mg of triamcinolone hexacetonide is not superior to triamcinolone hexacetonide alone for the treatment of knee synovitis in patients with rheumatoid arthritis at 1 y of follow-up.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Division of RheumatologyUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of RadiologyUNIFESP, EPM, Division of RheumatologyUNIFESP, EPM, Department of RadiologySciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Faculdade de Medicina / USPUniversidade Federal de São Paulo (UNIFESP)Santos, Marla Francisca dos [UNIFESP]Furtado, Rita Nely Vilar [UNIFESP]Konai, Monique Sayuri [UNIFESP]Castiglioni, Mario Luiz Vieira [UNIFESP]Marchetti, Renata Rosa [UNIFESP]Natour, Jamil [UNIFESP]2015-06-14T13:39:01Z2015-06-14T13:39:01Z2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1187-1193application/pdfhttp://dx.doi.org/10.1590/S1807-59322009001200008Clinics. Faculdade de Medicina / USP, v. 64, n. 12, p. 1187-1193, 2009.10.1590/S1807-59322009001200008S1807-59322009001200008.pdf1807-5932S1807-59322009001200008http://repositorio.unifesp.br/handle/11600/4836WOS:000273059400008ark:/48912/0013000011093engClinicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T03:37:11Zoai:repositorio.unifesp.br/:11600/4836Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:48:29.541239Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial |
title |
Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial |
spellingShingle |
Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial Santos, Marla Francisca dos [UNIFESP] Rheumatoid arthritis Intra-articular injection Radiosynoviorthesis Radiation synovectomy Samarium |
title_short |
Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial |
title_full |
Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial |
title_fullStr |
Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial |
title_full_unstemmed |
Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial |
title_sort |
Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial |
author |
Santos, Marla Francisca dos [UNIFESP] |
author_facet |
Santos, Marla Francisca dos [UNIFESP] Furtado, Rita Nely Vilar [UNIFESP] Konai, Monique Sayuri [UNIFESP] Castiglioni, Mario Luiz Vieira [UNIFESP] Marchetti, Renata Rosa [UNIFESP] Natour, Jamil [UNIFESP] |
author_role |
author |
author2 |
Furtado, Rita Nely Vilar [UNIFESP] Konai, Monique Sayuri [UNIFESP] Castiglioni, Mario Luiz Vieira [UNIFESP] Marchetti, Renata Rosa [UNIFESP] Natour, Jamil [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Santos, Marla Francisca dos [UNIFESP] Furtado, Rita Nely Vilar [UNIFESP] Konai, Monique Sayuri [UNIFESP] Castiglioni, Mario Luiz Vieira [UNIFESP] Marchetti, Renata Rosa [UNIFESP] Natour, Jamil [UNIFESP] |
dc.subject.por.fl_str_mv |
Rheumatoid arthritis Intra-articular injection Radiosynoviorthesis Radiation synovectomy Samarium |
topic |
Rheumatoid arthritis Intra-articular injection Radiosynoviorthesis Radiation synovectomy Samarium |
description |
OBJECTIVES: The aim of the present study was to investigate the effectiveness of Samarium153-particulate hydroxyapatite radiation synovectomy in rheumatoid arthritis patients with chronic knee synovitis. METHODS: Fifty-eight rheumatoid arthritis patients (60 knees) with chronic knee synovitis participated in a controlled double-blinded trial. Patients were randomized to receive either an intra-articular injection with 40 mg triamcinolone hexacetonide alone (TH group) or 40 mg triamcinolone hexacetonide combined with 15 mCi Samarium153-particulate hydroxyapatite (Sm/TH group). Blinded examination at baseline (T0) and at 1 (T1), 4 (T4), 12 (T12), 32 (T32), and 48 (T48) weeks post-intervention were performed on all patients and included a visual analog scale for joint pain and swelling as well as data on morning stiffness, flexion, extension, knee circumference, Likert scale of improvement, percentage of improvement, SF-36 generic quality of life questionnaire, Stanford Health Assessment Questionnaire (HAQ), Lequesne index, use of non-steroidal anti-inflammatory drugs or oral corticosteroids, events and adverse effects, calls to the physician, and hospital visits. RESULTS: The sample was homogeneous at baseline, and there were no withdrawals. Improvement was observed in both groups in relation to T0, but no statistically significant differences between groups were observed regarding all variables at the time points studied. The Sm/TH group exhibited more adverse effects at T1 (p<0.05), but these were mild and transitory. No severe adverse effects were reported during follow-up. CONCLUSION: Intra-articular injection of Samarium153-particulate hydroxyapatite (15 mCi) with 40 mg of triamcinolone hexacetonide is not superior to triamcinolone hexacetonide alone for the treatment of knee synovitis in patients with rheumatoid arthritis at 1 y of follow-up. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2015-06-14T13:39:01Z 2015-06-14T13:39:01Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1807-59322009001200008 Clinics. Faculdade de Medicina / USP, v. 64, n. 12, p. 1187-1193, 2009. 10.1590/S1807-59322009001200008 S1807-59322009001200008.pdf 1807-5932 S1807-59322009001200008 http://repositorio.unifesp.br/handle/11600/4836 WOS:000273059400008 |
dc.identifier.dark.fl_str_mv |
ark:/48912/0013000011093 |
url |
http://dx.doi.org/10.1590/S1807-59322009001200008 http://repositorio.unifesp.br/handle/11600/4836 |
identifier_str_mv |
Clinics. Faculdade de Medicina / USP, v. 64, n. 12, p. 1187-1193, 2009. 10.1590/S1807-59322009001200008 S1807-59322009001200008.pdf 1807-5932 S1807-59322009001200008 WOS:000273059400008 ark:/48912/0013000011093 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1187-1193 application/pdf |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina / USP |
publisher.none.fl_str_mv |
Faculdade de Medicina / USP |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1818602548014088192 |