Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial

Detalhes bibliográficos
Autor(a) principal: Santos, Marla Francisca dos [UNIFESP]
Data de Publicação: 2009
Outros Autores: Furtado, Rita Nely Vilar [UNIFESP], Konai, Monique Sayuri [UNIFESP], Castiglioni, Mario Luiz Vieira [UNIFESP], Marchetti, Renata Rosa [UNIFESP], Natour, Jamil [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000011093
Texto Completo: http://dx.doi.org/10.1590/S1807-59322009001200008
http://repositorio.unifesp.br/handle/11600/4836
Resumo: OBJECTIVES: The aim of the present study was to investigate the effectiveness of Samarium153-particulate hydroxyapatite radiation synovectomy in rheumatoid arthritis patients with chronic knee synovitis. METHODS: Fifty-eight rheumatoid arthritis patients (60 knees) with chronic knee synovitis participated in a controlled double-blinded trial. Patients were randomized to receive either an intra-articular injection with 40 mg triamcinolone hexacetonide alone (TH group) or 40 mg triamcinolone hexacetonide combined with 15 mCi Samarium153-particulate hydroxyapatite (Sm/TH group). Blinded examination at baseline (T0) and at 1 (T1), 4 (T4), 12 (T12), 32 (T32), and 48 (T48) weeks post-intervention were performed on all patients and included a visual analog scale for joint pain and swelling as well as data on morning stiffness, flexion, extension, knee circumference, Likert scale of improvement, percentage of improvement, SF-36 generic quality of life questionnaire, Stanford Health Assessment Questionnaire (HAQ), Lequesne index, use of non-steroidal anti-inflammatory drugs or oral corticosteroids, events and adverse effects, calls to the physician, and hospital visits. RESULTS: The sample was homogeneous at baseline, and there were no withdrawals. Improvement was observed in both groups in relation to T0, but no statistically significant differences between groups were observed regarding all variables at the time points studied. The Sm/TH group exhibited more adverse effects at T1 (p<0.05), but these were mild and transitory. No severe adverse effects were reported during follow-up. CONCLUSION: Intra-articular injection of Samarium153-particulate hydroxyapatite (15 mCi) with 40 mg of triamcinolone hexacetonide is not superior to triamcinolone hexacetonide alone for the treatment of knee synovitis in patients with rheumatoid arthritis at 1 y of follow-up.
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spelling Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trialRheumatoid arthritisIntra-articular injectionRadiosynoviorthesisRadiation synovectomySamariumOBJECTIVES: The aim of the present study was to investigate the effectiveness of Samarium153-particulate hydroxyapatite radiation synovectomy in rheumatoid arthritis patients with chronic knee synovitis. METHODS: Fifty-eight rheumatoid arthritis patients (60 knees) with chronic knee synovitis participated in a controlled double-blinded trial. Patients were randomized to receive either an intra-articular injection with 40 mg triamcinolone hexacetonide alone (TH group) or 40 mg triamcinolone hexacetonide combined with 15 mCi Samarium153-particulate hydroxyapatite (Sm/TH group). Blinded examination at baseline (T0) and at 1 (T1), 4 (T4), 12 (T12), 32 (T32), and 48 (T48) weeks post-intervention were performed on all patients and included a visual analog scale for joint pain and swelling as well as data on morning stiffness, flexion, extension, knee circumference, Likert scale of improvement, percentage of improvement, SF-36 generic quality of life questionnaire, Stanford Health Assessment Questionnaire (HAQ), Lequesne index, use of non-steroidal anti-inflammatory drugs or oral corticosteroids, events and adverse effects, calls to the physician, and hospital visits. RESULTS: The sample was homogeneous at baseline, and there were no withdrawals. Improvement was observed in both groups in relation to T0, but no statistically significant differences between groups were observed regarding all variables at the time points studied. The Sm/TH group exhibited more adverse effects at T1 (p<0.05), but these were mild and transitory. No severe adverse effects were reported during follow-up. CONCLUSION: Intra-articular injection of Samarium153-particulate hydroxyapatite (15 mCi) with 40 mg of triamcinolone hexacetonide is not superior to triamcinolone hexacetonide alone for the treatment of knee synovitis in patients with rheumatoid arthritis at 1 y of follow-up.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Division of RheumatologyUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of RadiologyUNIFESP, EPM, Division of RheumatologyUNIFESP, EPM, Department of RadiologySciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Faculdade de Medicina / USPUniversidade Federal de São Paulo (UNIFESP)Santos, Marla Francisca dos [UNIFESP]Furtado, Rita Nely Vilar [UNIFESP]Konai, Monique Sayuri [UNIFESP]Castiglioni, Mario Luiz Vieira [UNIFESP]Marchetti, Renata Rosa [UNIFESP]Natour, Jamil [UNIFESP]2015-06-14T13:39:01Z2015-06-14T13:39:01Z2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1187-1193application/pdfhttp://dx.doi.org/10.1590/S1807-59322009001200008Clinics. Faculdade de Medicina / USP, v. 64, n. 12, p. 1187-1193, 2009.10.1590/S1807-59322009001200008S1807-59322009001200008.pdf1807-5932S1807-59322009001200008http://repositorio.unifesp.br/handle/11600/4836WOS:000273059400008ark:/48912/0013000011093engClinicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T03:37:11Zoai:repositorio.unifesp.br/:11600/4836Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:48:29.541239Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
title Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
spellingShingle Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
Santos, Marla Francisca dos [UNIFESP]
Rheumatoid arthritis
Intra-articular injection
Radiosynoviorthesis
Radiation synovectomy
Samarium
title_short Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
title_full Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
title_fullStr Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
title_full_unstemmed Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
title_sort Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial
author Santos, Marla Francisca dos [UNIFESP]
author_facet Santos, Marla Francisca dos [UNIFESP]
Furtado, Rita Nely Vilar [UNIFESP]
Konai, Monique Sayuri [UNIFESP]
Castiglioni, Mario Luiz Vieira [UNIFESP]
Marchetti, Renata Rosa [UNIFESP]
Natour, Jamil [UNIFESP]
author_role author
author2 Furtado, Rita Nely Vilar [UNIFESP]
Konai, Monique Sayuri [UNIFESP]
Castiglioni, Mario Luiz Vieira [UNIFESP]
Marchetti, Renata Rosa [UNIFESP]
Natour, Jamil [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Santos, Marla Francisca dos [UNIFESP]
Furtado, Rita Nely Vilar [UNIFESP]
Konai, Monique Sayuri [UNIFESP]
Castiglioni, Mario Luiz Vieira [UNIFESP]
Marchetti, Renata Rosa [UNIFESP]
Natour, Jamil [UNIFESP]
dc.subject.por.fl_str_mv Rheumatoid arthritis
Intra-articular injection
Radiosynoviorthesis
Radiation synovectomy
Samarium
topic Rheumatoid arthritis
Intra-articular injection
Radiosynoviorthesis
Radiation synovectomy
Samarium
description OBJECTIVES: The aim of the present study was to investigate the effectiveness of Samarium153-particulate hydroxyapatite radiation synovectomy in rheumatoid arthritis patients with chronic knee synovitis. METHODS: Fifty-eight rheumatoid arthritis patients (60 knees) with chronic knee synovitis participated in a controlled double-blinded trial. Patients were randomized to receive either an intra-articular injection with 40 mg triamcinolone hexacetonide alone (TH group) or 40 mg triamcinolone hexacetonide combined with 15 mCi Samarium153-particulate hydroxyapatite (Sm/TH group). Blinded examination at baseline (T0) and at 1 (T1), 4 (T4), 12 (T12), 32 (T32), and 48 (T48) weeks post-intervention were performed on all patients and included a visual analog scale for joint pain and swelling as well as data on morning stiffness, flexion, extension, knee circumference, Likert scale of improvement, percentage of improvement, SF-36 generic quality of life questionnaire, Stanford Health Assessment Questionnaire (HAQ), Lequesne index, use of non-steroidal anti-inflammatory drugs or oral corticosteroids, events and adverse effects, calls to the physician, and hospital visits. RESULTS: The sample was homogeneous at baseline, and there were no withdrawals. Improvement was observed in both groups in relation to T0, but no statistically significant differences between groups were observed regarding all variables at the time points studied. The Sm/TH group exhibited more adverse effects at T1 (p<0.05), but these were mild and transitory. No severe adverse effects were reported during follow-up. CONCLUSION: Intra-articular injection of Samarium153-particulate hydroxyapatite (15 mCi) with 40 mg of triamcinolone hexacetonide is not superior to triamcinolone hexacetonide alone for the treatment of knee synovitis in patients with rheumatoid arthritis at 1 y of follow-up.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
2015-06-14T13:39:01Z
2015-06-14T13:39:01Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1807-59322009001200008
Clinics. Faculdade de Medicina / USP, v. 64, n. 12, p. 1187-1193, 2009.
10.1590/S1807-59322009001200008
S1807-59322009001200008.pdf
1807-5932
S1807-59322009001200008
http://repositorio.unifesp.br/handle/11600/4836
WOS:000273059400008
dc.identifier.dark.fl_str_mv ark:/48912/0013000011093
url http://dx.doi.org/10.1590/S1807-59322009001200008
http://repositorio.unifesp.br/handle/11600/4836
identifier_str_mv Clinics. Faculdade de Medicina / USP, v. 64, n. 12, p. 1187-1193, 2009.
10.1590/S1807-59322009001200008
S1807-59322009001200008.pdf
1807-5932
S1807-59322009001200008
WOS:000273059400008
ark:/48912/0013000011093
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1187-1193
application/pdf
dc.publisher.none.fl_str_mv Faculdade de Medicina / USP
publisher.none.fl_str_mv Faculdade de Medicina / USP
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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