Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

• Autor(a) principal: Moreira, Karin Monteiro [UNIFESP]
• Data de Publicação: 2010
• Outros Autores: Ferreira, Tatiana Lima [UNIFESP], Hipólide, Débora Cristina [UNIFESP], Fomari, Raquel Vecchio [UNIFESP], Tufik, Sergio [UNIFESP], Menezes Oliveira, Maria Gabriela [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://doi.org/10.1093/sleep/33.7.99; http://repositorio.unifesp.br/handle/11600/45609
• topic: Cognitive enhancer; emotional memory; acquisition; retrieval; learning; sleep

Study Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.