Alkaloids from croton echinocarpus baill.: Anti-hiv potential
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/49647 https://doi.org/10.1016/j.sajb.2015.06.011 |
Resumo: | Croton belongs to the Euphorbiaceae genus, one of the major Angiosperms families, and is widely distributed throughout the world, especially in the tropics. In this study, the hydroalcoholic extract (70% EtOH) of Croton echinocarpus leaves afforded two alkaloids: corydine and norisoboldine, and their structures were established by spectroscopic data interpretation (UV, IR, NMR and LREIMS). Both alkaloids displayed significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 100 mu g mL(-1) of norisoboldine and 450 mu g mL(-1) of corydine. Corydine showed IC50 of 356.8 mu g mL(-1), while norisoboldine was more efficient on inhibiting the RT activity, showing IC50 of 153.7 mu g mL(-1). (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved. |
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Ravanelli, N.Santos, Kátia P.Motta, Lucimar Barbosa daLago, Joao Henrique Ghilardi [UNIFESP]Furlan, Cláudia Maria2019-01-21T10:30:14Z2019-01-21T10:30:14Z2016South African Journal Of Botany. Amsterdam, v. 102, p. 153-156, 2016.0254-6299http://repositorio.unifesp.br/handle/11600/49647https://doi.org/10.1016/j.sajb.2015.06.01110.1016/j.sajb.2015.06.011WOS:000368959100021Croton belongs to the Euphorbiaceae genus, one of the major Angiosperms families, and is widely distributed throughout the world, especially in the tropics. In this study, the hydroalcoholic extract (70% EtOH) of Croton echinocarpus leaves afforded two alkaloids: corydine and norisoboldine, and their structures were established by spectroscopic data interpretation (UV, IR, NMR and LREIMS). Both alkaloids displayed significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 100 mu g mL(-1) of norisoboldine and 450 mu g mL(-1) of corydine. Corydine showed IC50 of 356.8 mu g mL(-1), while norisoboldine was more efficient on inhibiting the RT activity, showing IC50 of 153.7 mu g mL(-1). (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2012/10079-0]Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Department of Botany, Institute of Bioscience, University of São Paulo, Rua do Matão 277, CEP 05508-090 São Paulo, SP, BrazilUniversidade Paulista, Rua Apeninos 267, CEP 01533-000 São Paulo, SP, BrazilInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua Prof. Arthur Riedel 275, CEP 09972-270 Diadema, SP, BrazilInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua Prof. Arthur Riedel 275, CEP 09972-270 Diadema, SP, BrazilFAPESP: 2012/10079-0Web of Science153-156engElsevier science bvSouth African Journal Of BotanyNorisoboldineCorydineCrotonAnti-Hiv ActivityDragons BloodMolecular PhylogeneticsEuphorbiaceaeExtractsIdentificationConstituentsUrucuranaPlantsAlkaloids from croton echinocarpus baill.: Anti-hiv potentialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/496472021-09-28 16:10:24.306metadata only accessoai:repositorio.unifesp.br:11600/49647Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-28T19:10:24Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Alkaloids from croton echinocarpus baill.: Anti-hiv potential |
title |
Alkaloids from croton echinocarpus baill.: Anti-hiv potential |
spellingShingle |
Alkaloids from croton echinocarpus baill.: Anti-hiv potential Ravanelli, N. Norisoboldine Corydine Croton Anti-Hiv ActivityDragons Blood Molecular Phylogenetics Euphorbiaceae Extracts Identification Constituents Urucurana Plants |
title_short |
Alkaloids from croton echinocarpus baill.: Anti-hiv potential |
title_full |
Alkaloids from croton echinocarpus baill.: Anti-hiv potential |
title_fullStr |
Alkaloids from croton echinocarpus baill.: Anti-hiv potential |
title_full_unstemmed |
Alkaloids from croton echinocarpus baill.: Anti-hiv potential |
title_sort |
Alkaloids from croton echinocarpus baill.: Anti-hiv potential |
author |
Ravanelli, N. |
author_facet |
Ravanelli, N. Santos, Kátia P. Motta, Lucimar Barbosa da Lago, Joao Henrique Ghilardi [UNIFESP] Furlan, Cláudia Maria |
author_role |
author |
author2 |
Santos, Kátia P. Motta, Lucimar Barbosa da Lago, Joao Henrique Ghilardi [UNIFESP] Furlan, Cláudia Maria |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ravanelli, N. Santos, Kátia P. Motta, Lucimar Barbosa da Lago, Joao Henrique Ghilardi [UNIFESP] Furlan, Cláudia Maria |
dc.subject.eng.fl_str_mv |
Norisoboldine Corydine Croton Anti-Hiv ActivityDragons Blood Molecular Phylogenetics Euphorbiaceae Extracts Identification Constituents Urucurana Plants |
topic |
Norisoboldine Corydine Croton Anti-Hiv ActivityDragons Blood Molecular Phylogenetics Euphorbiaceae Extracts Identification Constituents Urucurana Plants |
description |
Croton belongs to the Euphorbiaceae genus, one of the major Angiosperms families, and is widely distributed throughout the world, especially in the tropics. In this study, the hydroalcoholic extract (70% EtOH) of Croton echinocarpus leaves afforded two alkaloids: corydine and norisoboldine, and their structures were established by spectroscopic data interpretation (UV, IR, NMR and LREIMS). Both alkaloids displayed significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 100 mu g mL(-1) of norisoboldine and 450 mu g mL(-1) of corydine. Corydine showed IC50 of 356.8 mu g mL(-1), while norisoboldine was more efficient on inhibiting the RT activity, showing IC50 of 153.7 mu g mL(-1). (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2019-01-21T10:30:14Z |
dc.date.available.fl_str_mv |
2019-01-21T10:30:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
South African Journal Of Botany. Amsterdam, v. 102, p. 153-156, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/49647 https://doi.org/10.1016/j.sajb.2015.06.011 |
dc.identifier.issn.none.fl_str_mv |
0254-6299 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.sajb.2015.06.011 |
dc.identifier.wos.none.fl_str_mv |
WOS:000368959100021 |
identifier_str_mv |
South African Journal Of Botany. Amsterdam, v. 102, p. 153-156, 2016. 0254-6299 10.1016/j.sajb.2015.06.011 WOS:000368959100021 |
url |
http://repositorio.unifesp.br/handle/11600/49647 https://doi.org/10.1016/j.sajb.2015.06.011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
South African Journal Of Botany |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
153-156 |
dc.publisher.none.fl_str_mv |
Elsevier science bv |
publisher.none.fl_str_mv |
Elsevier science bv |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764138589454336 |