Placental transfer and maternally acquired neonatal IgG immunity in human immunodeficiency virus infection

• Autor(a) principal: Moraes-Pinto, Maria Isabel de
• Data de Publicação: 1996
• Outros Autores: Almeida, Ana CM, Kenj, Grecy, Filgueiras, Thomas E., Tobias, Wanda, Santos, Amélia MN, Carneiro Sampaio, Magda MS, Farhat, Calil K., Milligan, Paul JM, Johnson, Peter M., Hart, Charles A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1093/infdis/173.5.1077; http://repositorio.unifesp.br/handle/11600/44431

Transplacental transfer of specific IgG antibodies was studied in 46 pairs of human immunodeficiency virus type 1 (HIV-1)-seropositive women and their neonates and in 53 pairs of healthy HIV-seronegative mothers and their newborns, Neonatal and maternal sera were assessed by nephelometry for total levels of serum IgG and by ELISA for IgG antibodies to herpes simplex virus (HSV), varicella-zoster virus (VZV), measles virus, tetanus toroid, streptolysin O, and Streptococcus pneumoniae capsular antigens. Placental transfer of IgG antibodies to VZV, tetanus toroid, measles, streptolysin O, and S. pneumoniae was decreased by maternal HIV infection, Maternal levels of total IgG had an independent effect on transfer of antibodies to HSV, VZV, measles, and S. pneumoniae. Neonatal antibody levels to tetanus toroid, measles, and S. pneumoniae were significantly lower in the HIV group, Both maternal hypergammaglobulinemia and maternal HIV infection may contribute to these low antibody levels at birth and thus lead to early infection in this high-risk population.