Action of plant proteinase inhibitors on enzymes of physiopathological importance

Detalhes bibliográficos
Autor(a) principal: Oliva, Maria Luiza Vilela [UNIFESP]
Data de Publicação: 2009
Outros Autores: Sampaio, Misako Uemura [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0001-37652009000300023
http://repositorio.unifesp.br/handle/11600/42527
Resumo: Obtained from leguminous seeds, various plant proteins inhibit animal proteinases, including human, and can be considered for the development of compounds with biological activity. Inhibitors from the Bowman-Birk and plant Kunitz-type family have been characterized by proteinase specificity, primary structure and reactive site. Our group mostly studies the genus Bauhinia, mainly the species bauhinioides, rufa, ungulata and variegata. In some species, more than one inhibitor was characterized, exhibiting different properties. Although proteins from this group share high structural similarity, they present differences in proteinase inhibition, explored in studies using diverse biological models.
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spelling Action of plant proteinase inhibitors on enzymes of physiopathological importanceBowman-BirkchymotrypsinKunitz inhibitorsplasma kallikreinprimary structuretrypsinObtained from leguminous seeds, various plant proteins inhibit animal proteinases, including human, and can be considered for the development of compounds with biological activity. Inhibitors from the Bowman-Birk and plant Kunitz-type family have been characterized by proteinase specificity, primary structure and reactive site. Our group mostly studies the genus Bauhinia, mainly the species bauhinioides, rufa, ungulata and variegata. In some species, more than one inhibitor was characterized, exhibiting different properties. Although proteins from this group share high structural similarity, they present differences in proteinase inhibition, explored in studies using diverse biological models.Univ Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, BR-04044020 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, BR-04044020 Sao Paulo, BrazilWeb of ScienceCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundo de Auxilio aos Docentes e Alunos/Fundacao de Apoio a UNIFESP (FADA/FAP)Acad Brasileira De CienciasUniversidade Federal de São Paulo (UNIFESP)Oliva, Maria Luiza Vilela [UNIFESP]Sampaio, Misako Uemura [UNIFESP]2018-06-15T13:50:09Z2018-06-15T13:50:09Z2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion615-621http://dx.doi.org/10.1590/S0001-37652009000300023Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 81, n. 3, p. 615-621, 2009.10.1590/S0001-37652009000300023S0001-37652009000300023.pdf0001-3765S0001-37652009000300023http://repositorio.unifesp.br/handle/11600/42527WOS:000269462300023engAnais Da Academia Brasileira De Cienciasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T11:58:37Zoai:repositorio.unifesp.br/:11600/42527Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T11:58:37Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Action of plant proteinase inhibitors on enzymes of physiopathological importance
title Action of plant proteinase inhibitors on enzymes of physiopathological importance
spellingShingle Action of plant proteinase inhibitors on enzymes of physiopathological importance
Oliva, Maria Luiza Vilela [UNIFESP]
Bowman-Birk
chymotrypsin
Kunitz inhibitors
plasma kallikrein
primary structure
trypsin
title_short Action of plant proteinase inhibitors on enzymes of physiopathological importance
title_full Action of plant proteinase inhibitors on enzymes of physiopathological importance
title_fullStr Action of plant proteinase inhibitors on enzymes of physiopathological importance
title_full_unstemmed Action of plant proteinase inhibitors on enzymes of physiopathological importance
title_sort Action of plant proteinase inhibitors on enzymes of physiopathological importance
author Oliva, Maria Luiza Vilela [UNIFESP]
author_facet Oliva, Maria Luiza Vilela [UNIFESP]
Sampaio, Misako Uemura [UNIFESP]
author_role author
author2 Sampaio, Misako Uemura [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Oliva, Maria Luiza Vilela [UNIFESP]
Sampaio, Misako Uemura [UNIFESP]
dc.subject.por.fl_str_mv Bowman-Birk
chymotrypsin
Kunitz inhibitors
plasma kallikrein
primary structure
trypsin
topic Bowman-Birk
chymotrypsin
Kunitz inhibitors
plasma kallikrein
primary structure
trypsin
description Obtained from leguminous seeds, various plant proteins inhibit animal proteinases, including human, and can be considered for the development of compounds with biological activity. Inhibitors from the Bowman-Birk and plant Kunitz-type family have been characterized by proteinase specificity, primary structure and reactive site. Our group mostly studies the genus Bauhinia, mainly the species bauhinioides, rufa, ungulata and variegata. In some species, more than one inhibitor was characterized, exhibiting different properties. Although proteins from this group share high structural similarity, they present differences in proteinase inhibition, explored in studies using diverse biological models.
publishDate 2009
dc.date.none.fl_str_mv 2009-09-01
2018-06-15T13:50:09Z
2018-06-15T13:50:09Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0001-37652009000300023
Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 81, n. 3, p. 615-621, 2009.
10.1590/S0001-37652009000300023
S0001-37652009000300023.pdf
0001-3765
S0001-37652009000300023
http://repositorio.unifesp.br/handle/11600/42527
WOS:000269462300023
url http://dx.doi.org/10.1590/S0001-37652009000300023
http://repositorio.unifesp.br/handle/11600/42527
identifier_str_mv Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 81, n. 3, p. 615-621, 2009.
10.1590/S0001-37652009000300023
S0001-37652009000300023.pdf
0001-3765
S0001-37652009000300023
WOS:000269462300023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Da Academia Brasileira De Ciencias
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 615-621
dc.publisher.none.fl_str_mv Acad Brasileira De Ciencias
publisher.none.fl_str_mv Acad Brasileira De Ciencias
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268436563361792

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