TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/44121 http://www.ingentaconnect.com/contentone/iuatld/ijtld/2005/00000009/00000007/art00011 |
Resumo: | SETTING: A major university in Sao Paulo, Brazil, where vaccination against tuberculosis (TB) with bacille Calmette-Guerin (BCG) was routinely offered to first-year medical and nursing students.OBJECTIVES: To estimate the probability of negative tuberculin skin test (TST) results over a 4-year period following BCG revaccination, and to evaluate the effect of factors associated with reversion.DESIGN: Students were enrolled in 1997, initially given a two-step TST, and were retested annually or biannually for the duration of the study. Data on TB exposures and potential risk factors for TST negativity and reversion were collected through annual surveys. A linear mixture survival model was used to estimate the probability of negative TST results over time.RESULTS: Of 159 students, an estimated 20% had a negative TST result despite revaccination, and a further 31% reverted to negative over 4 years of follow-up. No cofactors significantly affected the probability of reversion.CONCLUSION: Overall, in the absence of reported exposure to Mycobacterium tuberculosis, 51% of students revaccinated upon entering nursing or medical school would have a negative TST result by the time they begin their internships. In this recently vaccinated population, reversion was common, suggesting that annual TST screening may remain a useful tool. |
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Levy, M. Z.Medeiros, Eduardo Alexandrino Servolo de [UNIFESP]Shang, N.Soares, MCS [UNIFESP]Homenko, A. S. [UNIFESP]Almeida, R. M. [UNIFESP]Garrett, D. O.Roth, V. R.Jarvis, W. R.Wells, C. D.Binkin, N.Laserson, K. F.Ctr Dis Control & PreventEmory UnivUniversidade Federal de São Paulo (UNIFESP)Minist HlthOttawa HospInst Super Sanita2018-06-15T17:49:48Z2018-06-15T17:49:48Z2005-07-01International Journal Of Tuberculosis And Lung Disease. Paris: Int Union Against Tuberculosis Lung Disease (i U A T L D), v. 9, n. 7, p. 771-776, 2005.1027-3719http://repositorio.unifesp.br/11600/44121http://www.ingentaconnect.com/contentone/iuatld/ijtld/2005/00000009/00000007/art00011WOS:000230574000011SETTING: A major university in Sao Paulo, Brazil, where vaccination against tuberculosis (TB) with bacille Calmette-Guerin (BCG) was routinely offered to first-year medical and nursing students.OBJECTIVES: To estimate the probability of negative tuberculin skin test (TST) results over a 4-year period following BCG revaccination, and to evaluate the effect of factors associated with reversion.DESIGN: Students were enrolled in 1997, initially given a two-step TST, and were retested annually or biannually for the duration of the study. Data on TB exposures and potential risk factors for TST negativity and reversion were collected through annual surveys. A linear mixture survival model was used to estimate the probability of negative TST results over time.RESULTS: Of 159 students, an estimated 20% had a negative TST result despite revaccination, and a further 31% reverted to negative over 4 years of follow-up. No cofactors significantly affected the probability of reversion.CONCLUSION: Overall, in the absence of reported exposure to Mycobacterium tuberculosis, 51% of students revaccinated upon entering nursing or medical school would have a negative TST result by the time they begin their internships. In this recently vaccinated population, reversion was common, suggesting that annual TST screening may remain a useful tool.Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USAEmory Univ, Program Populat Biol Evolut & Ecol, Atlanta, GA 30322 USAUniv Fed Sao Paulo, Comissao Epidemiol Hosp, Disciplina Doencas Infecciosas & Parasitarias, Sao Paulo, BrazilMinist Hlth, Secretariat Hlth Surveillance, Natl Program TB Control, Brasilia, DF, BrazilCtr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Infect Dis, Atlanta, GA USAOttawa Hosp, Infect Prevent & Control Dept, Ottawa, ON, CanadaInst Super Sanita, Rome, ItalyUniv Fed Sao Paulo, Comissao Epidemiol Hosp, Disciplina Doencas Infecciosas & Parasitarias, Sao Paulo, BrazilWeb of Science771-776engInt Union Against Tuberculosis Lung Disease (i U A T L D)International Journal Of Tuberculosis And Lung DiseasetuberculosisBCGtuberculin skin testBrazilTST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/441212021-10-05 21:55:27.671metadata only accessoai:repositorio.unifesp.br:11600/44121Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:55:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000 |
title |
TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000 |
spellingShingle |
TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000 Levy, M. Z. tuberculosis BCG tuberculin skin test Brazil |
title_short |
TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000 |
title_full |
TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000 |
title_fullStr |
TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000 |
title_full_unstemmed |
TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000 |
title_sort |
TST reversion in a BCG-revaccinated population of nursing and medical students, Sao Paulo, Brazil, 1997-2000 |
author |
Levy, M. Z. |
author_facet |
Levy, M. Z. Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] Shang, N. Soares, MCS [UNIFESP] Homenko, A. S. [UNIFESP] Almeida, R. M. [UNIFESP] Garrett, D. O. Roth, V. R. Jarvis, W. R. Wells, C. D. Binkin, N. Laserson, K. F. |
author_role |
author |
author2 |
Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] Shang, N. Soares, MCS [UNIFESP] Homenko, A. S. [UNIFESP] Almeida, R. M. [UNIFESP] Garrett, D. O. Roth, V. R. Jarvis, W. R. Wells, C. D. Binkin, N. Laserson, K. F. |
author2_role |
author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Ctr Dis Control & Prevent Emory Univ Universidade Federal de São Paulo (UNIFESP) Minist Hlth Ottawa Hosp Inst Super Sanita |
dc.contributor.author.fl_str_mv |
Levy, M. Z. Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] Shang, N. Soares, MCS [UNIFESP] Homenko, A. S. [UNIFESP] Almeida, R. M. [UNIFESP] Garrett, D. O. Roth, V. R. Jarvis, W. R. Wells, C. D. Binkin, N. Laserson, K. F. |
dc.subject.eng.fl_str_mv |
tuberculosis BCG tuberculin skin test Brazil |
topic |
tuberculosis BCG tuberculin skin test Brazil |
description |
SETTING: A major university in Sao Paulo, Brazil, where vaccination against tuberculosis (TB) with bacille Calmette-Guerin (BCG) was routinely offered to first-year medical and nursing students.OBJECTIVES: To estimate the probability of negative tuberculin skin test (TST) results over a 4-year period following BCG revaccination, and to evaluate the effect of factors associated with reversion.DESIGN: Students were enrolled in 1997, initially given a two-step TST, and were retested annually or biannually for the duration of the study. Data on TB exposures and potential risk factors for TST negativity and reversion were collected through annual surveys. A linear mixture survival model was used to estimate the probability of negative TST results over time.RESULTS: Of 159 students, an estimated 20% had a negative TST result despite revaccination, and a further 31% reverted to negative over 4 years of follow-up. No cofactors significantly affected the probability of reversion.CONCLUSION: Overall, in the absence of reported exposure to Mycobacterium tuberculosis, 51% of students revaccinated upon entering nursing or medical school would have a negative TST result by the time they begin their internships. In this recently vaccinated population, reversion was common, suggesting that annual TST screening may remain a useful tool. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-07-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T17:49:48Z |
dc.date.available.fl_str_mv |
2018-06-15T17:49:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
International Journal Of Tuberculosis And Lung Disease. Paris: Int Union Against Tuberculosis Lung Disease (i U A T L D), v. 9, n. 7, p. 771-776, 2005. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/44121 http://www.ingentaconnect.com/contentone/iuatld/ijtld/2005/00000009/00000007/art00011 |
dc.identifier.issn.none.fl_str_mv |
1027-3719 |
dc.identifier.wos.none.fl_str_mv |
WOS:000230574000011 |
identifier_str_mv |
International Journal Of Tuberculosis And Lung Disease. Paris: Int Union Against Tuberculosis Lung Disease (i U A T L D), v. 9, n. 7, p. 771-776, 2005. 1027-3719 WOS:000230574000011 |
url |
http://repositorio.unifesp.br/11600/44121 http://www.ingentaconnect.com/contentone/iuatld/ijtld/2005/00000009/00000007/art00011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
International Journal Of Tuberculosis And Lung Disease |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
771-776 |
dc.publisher.none.fl_str_mv |
Int Union Against Tuberculosis Lung Disease (i U A T L D) |
publisher.none.fl_str_mv |
Int Union Against Tuberculosis Lung Disease (i U A T L D) |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764135721598976 |