Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/2671 http://dx.doi.org/10.1590/S0100-879X2005000900013 |
Resumo: | In contrast to most developed countries, most patients with primary hyperparathyroidism in Brazil are still symptomatic at diagnosis. However, we have been observing a change in this pattern, especially in the last few years. We evaluated 104 patients, 77 females and 27 males aged 11-79 years (mean: 54.4 years), diagnosed between 1985 and 2002 at a University Hospital. Diagnosis was made on the basis of clinical findings and of high total and/or ionized calcium levels, high or inappropriate levels of intact parathyroid hormone and of surgical findings in 80 patients. Patients were divided into three groups, i.e., patients diagnosed from 1985 to 1989, patients diagnosed from 1990 to 1994, and patients diagnosed from 1995 to 2002. The number of new cases diagnosed/year increased from 1.8/year in the first group to 6.0/year in the second group and 8.1/year in the third group. The first group comprised 9 patients (mean serum calcium ± SD, 13.6 ± 1.6 mg/dl), 8 of them (88.8%) defined as symptomatic. The second group comprised 30 patients (mean calcium ± SD, 12.2 ± 1.63 mg/dl), 22 of them defined as symptomatic (73.3%). The third group contained 65 patients (mean calcium 11.7 ± 1.1 mg/dl), 34 of them symptomatic (52.3%). Patients from the first group tended to be younger (mean ± SD, 43.0 ± 15 vs 55.1 ± 14.4 and 55.7 ± 17.3 years, respectively) and their mean serum calcium was significantly higher (P < 0.05). All of symptomatic patients independent of group had higher serum calcium levels (12.4 ± 1.53 mg/dl, N = 64) than asymptomatic patients (11.4 ± 1.0 mg/dl, N = 40). Our data showed an increase in the percentage of asymptomatic patients over the years in the number of primary hyperparathyroidism cases diagnosed. This finding may be due to an increased availability of diagnostic methods and/or to an increased awareness about the disease. |
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Ohe, Monique Nakayama [UNIFESP]Santos, Rodrigo Oliveira [UNIFESP]Barros, Elizabete Ribeiro [UNIFESP]Lage, Andrea Zacouteguy [UNIFESP]Kunii, Ilda Sizue [UNIFESP]Abrahão, Márcio [UNIFESP]Cervantes, Onivaldo [UNIFESP]Hauache, Omar Magid [UNIFESP]Lazaretti-Castro, Marise [UNIFESP]Vieira, José Gilberto Henriques [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:31:43Z2015-06-14T13:31:43Z2005-09-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 9, p. 1383-1387, 2005.0100-879Xhttp://repositorio.unifesp.br/handle/11600/2671http://dx.doi.org/10.1590/S0100-879X2005000900013S0100-879X2005000900013.pdfS0100-879X200500090001310.1590/S0100-879X2005000900013WOS:000231773600013In contrast to most developed countries, most patients with primary hyperparathyroidism in Brazil are still symptomatic at diagnosis. However, we have been observing a change in this pattern, especially in the last few years. We evaluated 104 patients, 77 females and 27 males aged 11-79 years (mean: 54.4 years), diagnosed between 1985 and 2002 at a University Hospital. Diagnosis was made on the basis of clinical findings and of high total and/or ionized calcium levels, high or inappropriate levels of intact parathyroid hormone and of surgical findings in 80 patients. Patients were divided into three groups, i.e., patients diagnosed from 1985 to 1989, patients diagnosed from 1990 to 1994, and patients diagnosed from 1995 to 2002. The number of new cases diagnosed/year increased from 1.8/year in the first group to 6.0/year in the second group and 8.1/year in the third group. The first group comprised 9 patients (mean serum calcium ± SD, 13.6 ± 1.6 mg/dl), 8 of them (88.8%) defined as symptomatic. The second group comprised 30 patients (mean calcium ± SD, 12.2 ± 1.63 mg/dl), 22 of them defined as symptomatic (73.3%). The third group contained 65 patients (mean calcium 11.7 ± 1.1 mg/dl), 34 of them symptomatic (52.3%). Patients from the first group tended to be younger (mean ± SD, 43.0 ± 15 vs 55.1 ± 14.4 and 55.7 ± 17.3 years, respectively) and their mean serum calcium was significantly higher (P < 0.05). All of symptomatic patients independent of group had higher serum calcium levels (12.4 ± 1.53 mg/dl, N = 64) than asymptomatic patients (11.4 ± 1.0 mg/dl, N = 40). Our data showed an increase in the percentage of asymptomatic patients over the years in the number of primary hyperparathyroidism cases diagnosed. This finding may be due to an increased availability of diagnostic methods and/or to an increased awareness about the disease.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de MedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Otorrinolaringologia e Cirurgia de Cabeça e PescoçoUNIFESP, EPM, Depto. de MedicinaUNIFESP, EPM, Depto. de Otorrinolaringologia e Cirurgia de Cabeça e PescoçoSciELO1383-1387engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchPrimary hyperparathyroidismHypercalcemiaClinical presentationAsymptomatic primary hyperparathyroidismParathyroid hormoneHyperparathyroidismChanges in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2005000900013.pdfapplication/pdf469492${dspace.ui.url}/bitstream/11600/2671/1/S0100-879X2005000900013.pdf11ee43df87f31e9684409c407303d404MD51open accessTEXTS0100-879X2005000900013.pdf.txtS0100-879X2005000900013.pdf.txtExtracted texttext/plain17617${dspace.ui.url}/bitstream/11600/2671/2/S0100-879X2005000900013.pdf.txt5377fca087a15b1d394593bbc64c9239MD52open access11600/26712021-09-30 11:01:06.957open accessoai:repositorio.unifesp.br:11600/2671Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:15:09.944019Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 |
title |
Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 |
spellingShingle |
Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 Ohe, Monique Nakayama [UNIFESP] Primary hyperparathyroidism Hypercalcemia Clinical presentation Asymptomatic primary hyperparathyroidism Parathyroid hormone Hyperparathyroidism |
title_short |
Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 |
title_full |
Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 |
title_fullStr |
Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 |
title_full_unstemmed |
Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 |
title_sort |
Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 |
author |
Ohe, Monique Nakayama [UNIFESP] |
author_facet |
Ohe, Monique Nakayama [UNIFESP] Santos, Rodrigo Oliveira [UNIFESP] Barros, Elizabete Ribeiro [UNIFESP] Lage, Andrea Zacouteguy [UNIFESP] Kunii, Ilda Sizue [UNIFESP] Abrahão, Márcio [UNIFESP] Cervantes, Onivaldo [UNIFESP] Hauache, Omar Magid [UNIFESP] Lazaretti-Castro, Marise [UNIFESP] Vieira, José Gilberto Henriques [UNIFESP] |
author_role |
author |
author2 |
Santos, Rodrigo Oliveira [UNIFESP] Barros, Elizabete Ribeiro [UNIFESP] Lage, Andrea Zacouteguy [UNIFESP] Kunii, Ilda Sizue [UNIFESP] Abrahão, Márcio [UNIFESP] Cervantes, Onivaldo [UNIFESP] Hauache, Omar Magid [UNIFESP] Lazaretti-Castro, Marise [UNIFESP] Vieira, José Gilberto Henriques [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Ohe, Monique Nakayama [UNIFESP] Santos, Rodrigo Oliveira [UNIFESP] Barros, Elizabete Ribeiro [UNIFESP] Lage, Andrea Zacouteguy [UNIFESP] Kunii, Ilda Sizue [UNIFESP] Abrahão, Márcio [UNIFESP] Cervantes, Onivaldo [UNIFESP] Hauache, Omar Magid [UNIFESP] Lazaretti-Castro, Marise [UNIFESP] Vieira, José Gilberto Henriques [UNIFESP] |
dc.subject.eng.fl_str_mv |
Primary hyperparathyroidism Hypercalcemia Clinical presentation Asymptomatic primary hyperparathyroidism Parathyroid hormone Hyperparathyroidism |
topic |
Primary hyperparathyroidism Hypercalcemia Clinical presentation Asymptomatic primary hyperparathyroidism Parathyroid hormone Hyperparathyroidism |
description |
In contrast to most developed countries, most patients with primary hyperparathyroidism in Brazil are still symptomatic at diagnosis. However, we have been observing a change in this pattern, especially in the last few years. We evaluated 104 patients, 77 females and 27 males aged 11-79 years (mean: 54.4 years), diagnosed between 1985 and 2002 at a University Hospital. Diagnosis was made on the basis of clinical findings and of high total and/or ionized calcium levels, high or inappropriate levels of intact parathyroid hormone and of surgical findings in 80 patients. Patients were divided into three groups, i.e., patients diagnosed from 1985 to 1989, patients diagnosed from 1990 to 1994, and patients diagnosed from 1995 to 2002. The number of new cases diagnosed/year increased from 1.8/year in the first group to 6.0/year in the second group and 8.1/year in the third group. The first group comprised 9 patients (mean serum calcium ± SD, 13.6 ± 1.6 mg/dl), 8 of them (88.8%) defined as symptomatic. The second group comprised 30 patients (mean calcium ± SD, 12.2 ± 1.63 mg/dl), 22 of them defined as symptomatic (73.3%). The third group contained 65 patients (mean calcium 11.7 ± 1.1 mg/dl), 34 of them symptomatic (52.3%). Patients from the first group tended to be younger (mean ± SD, 43.0 ± 15 vs 55.1 ± 14.4 and 55.7 ± 17.3 years, respectively) and their mean serum calcium was significantly higher (P < 0.05). All of symptomatic patients independent of group had higher serum calcium levels (12.4 ± 1.53 mg/dl, N = 64) than asymptomatic patients (11.4 ± 1.0 mg/dl, N = 40). Our data showed an increase in the percentage of asymptomatic patients over the years in the number of primary hyperparathyroidism cases diagnosed. This finding may be due to an increased availability of diagnostic methods and/or to an increased awareness about the disease. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-09-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:31:43Z |
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2015-06-14T13:31:43Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 9, p. 1383-1387, 2005. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/2671 http://dx.doi.org/10.1590/S0100-879X2005000900013 |
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0100-879X |
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S0100-879X2005000900013.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2005000900013 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2005000900013 |
dc.identifier.wos.none.fl_str_mv |
WOS:000231773600013 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 9, p. 1383-1387, 2005. 0100-879X S0100-879X2005000900013.pdf S0100-879X2005000900013 10.1590/S0100-879X2005000900013 WOS:000231773600013 |
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http://repositorio.unifesp.br/handle/11600/2671 http://dx.doi.org/10.1590/S0100-879X2005000900013 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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