Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/34622 https://dx.doi.org/10.1016/j.neulet.2011.12.052 |
Resumo: | Prepulse inhibition (PPI) is the reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus and is an operational measure of sensorimotor gating. PPI is impaired in schizophrenia patients and in rats with central dopamine (DA) activation. the inferior colliculus (IC) is a critical part of the auditory pathway mediating acoustic PPI. the activation of the IC by the acoustic prepulse reduces startle magnitude. the aim of this study was to elucidate the role of DA transmission of the IC on the development of acoustic PPI. Bilateral microinjections of apomorphine (9.0 mu g/0.5 mu L) an agonist of D-2 receptors, into the IC disrupted PPI while microinjections of haloperidol (0.5 mu g/0.5 mu L), an antagonist of D-2 receptors, into this structure did not alter PPI. These results suggest that dopamine-mediated mechanisms of the IC are involved in the expression of PPI in rodents. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
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Satake, Susan [UNIFESP]Yamada, Karen Yukie [UNIFESP]Melo, Liana Lins [UNIFESP]Silva, Regina Cláudia Barbosa da [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:17:55Z2016-01-24T14:17:55Z2012-02-10Neuroscience Letters. Clare: Elsevier B.V., v. 509, n. 1, p. 60-63, 2012.0304-3940https://repositorio.unifesp.br/handle/11600/34622https://dx.doi.org/10.1016/j.neulet.2011.12.052WOS000301097100013.pdf10.1016/j.neulet.2011.12.052WOS:000301097100013Prepulse inhibition (PPI) is the reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus and is an operational measure of sensorimotor gating. PPI is impaired in schizophrenia patients and in rats with central dopamine (DA) activation. the inferior colliculus (IC) is a critical part of the auditory pathway mediating acoustic PPI. the activation of the IC by the acoustic prepulse reduces startle magnitude. the aim of this study was to elucidate the role of DA transmission of the IC on the development of acoustic PPI. Bilateral microinjections of apomorphine (9.0 mu g/0.5 mu L) an agonist of D-2 receptors, into the IC disrupted PPI while microinjections of haloperidol (0.5 mu g/0.5 mu L), an antagonist of D-2 receptors, into this structure did not alter PPI. These results suggest that dopamine-mediated mechanisms of the IC are involved in the expression of PPI in rodents. (C) 2011 Elsevier Ireland Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo Unifesp, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP, BrazilUniversidade Federal de São Paulo Unifesp, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP, BrazilFAPESP: 09/05703-4FAPESP: 09/07347-0FAPESP: 09/07278-9Web of Science60-63engElsevier B.V.Neuroscience Lettershttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessApomorphineHaloperidolInferior colliculusPrepulse inhibitionRatSchizophreniaEffects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in ratinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000301097100013.pdfapplication/pdf496889${dspace.ui.url}/bitstream/11600/34622/1/WOS000301097100013.pdf7e3383d9664a91d62d76ab35879c98bbMD51open accessTEXTWOS000301097100013.pdf.txtWOS000301097100013.pdf.txtExtracted texttext/plain24994${dspace.ui.url}/bitstream/11600/34622/6/WOS000301097100013.pdf.txtb2e61f4a386611b2800dba4b66baf8d8MD56open accessTHUMBNAILWOS000301097100013.pdf.jpgWOS000301097100013.pdf.jpgIM Thumbnailimage/jpeg7164${dspace.ui.url}/bitstream/11600/34622/8/WOS000301097100013.pdf.jpgf2a91d6f493e53f273726649c21829b9MD58open access11600/346222023-06-05 19:14:33.892open accessoai:repositorio.unifesp.br:11600/34622Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:14:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat |
title |
Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat |
spellingShingle |
Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat Satake, Susan [UNIFESP] Apomorphine Haloperidol Inferior colliculus Prepulse inhibition Rat Schizophrenia |
title_short |
Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat |
title_full |
Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat |
title_fullStr |
Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat |
title_full_unstemmed |
Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat |
title_sort |
Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat |
author |
Satake, Susan [UNIFESP] |
author_facet |
Satake, Susan [UNIFESP] Yamada, Karen Yukie [UNIFESP] Melo, Liana Lins [UNIFESP] Silva, Regina Cláudia Barbosa da [UNIFESP] |
author_role |
author |
author2 |
Yamada, Karen Yukie [UNIFESP] Melo, Liana Lins [UNIFESP] Silva, Regina Cláudia Barbosa da [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Satake, Susan [UNIFESP] Yamada, Karen Yukie [UNIFESP] Melo, Liana Lins [UNIFESP] Silva, Regina Cláudia Barbosa da [UNIFESP] |
dc.subject.eng.fl_str_mv |
Apomorphine Haloperidol Inferior colliculus Prepulse inhibition Rat Schizophrenia |
topic |
Apomorphine Haloperidol Inferior colliculus Prepulse inhibition Rat Schizophrenia |
description |
Prepulse inhibition (PPI) is the reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus and is an operational measure of sensorimotor gating. PPI is impaired in schizophrenia patients and in rats with central dopamine (DA) activation. the inferior colliculus (IC) is a critical part of the auditory pathway mediating acoustic PPI. the activation of the IC by the acoustic prepulse reduces startle magnitude. the aim of this study was to elucidate the role of DA transmission of the IC on the development of acoustic PPI. Bilateral microinjections of apomorphine (9.0 mu g/0.5 mu L) an agonist of D-2 receptors, into the IC disrupted PPI while microinjections of haloperidol (0.5 mu g/0.5 mu L), an antagonist of D-2 receptors, into this structure did not alter PPI. These results suggest that dopamine-mediated mechanisms of the IC are involved in the expression of PPI in rodents. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-02-10 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:17:55Z |
dc.date.available.fl_str_mv |
2016-01-24T14:17:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Neuroscience Letters. Clare: Elsevier B.V., v. 509, n. 1, p. 60-63, 2012. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/34622 https://dx.doi.org/10.1016/j.neulet.2011.12.052 |
dc.identifier.issn.none.fl_str_mv |
0304-3940 |
dc.identifier.file.none.fl_str_mv |
WOS000301097100013.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.neulet.2011.12.052 |
dc.identifier.wos.none.fl_str_mv |
WOS:000301097100013 |
identifier_str_mv |
Neuroscience Letters. Clare: Elsevier B.V., v. 509, n. 1, p. 60-63, 2012. 0304-3940 WOS000301097100013.pdf 10.1016/j.neulet.2011.12.052 WOS:000301097100013 |
url |
https://repositorio.unifesp.br/handle/11600/34622 https://dx.doi.org/10.1016/j.neulet.2011.12.052 |
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eng |
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eng |
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Neuroscience Letters |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
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60-63 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
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Elsevier B.V. |
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