Modificação do metodo kindling para obtenção de status epilepticus experimental em ratos

• Autor(a) principal: Campos, Carlos J. Reis De
• Data de Publicação: 1980
• Outros Autores: Cavalheiro, Esper Abrão [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-282X1980000100010; http://repositorio.unifesp.br/handle/11600/176

Taber et al. (1977) introduced new model of epilepsy to obtain experimental status epilepticus in mice, through a modification of the kindling method (Goddard et al. 1969). The aim of this paper is to report the effect of Taber's modification on a new animal specie (rats). Bipolar, twisted steel electrodes were stereotaxically implanted into the CA1-CA3 regions of the dorsal hippocampus. After one week the animals received 2 h stimulation sessions, one stimulus per minute, during which a sustained electrographical and behavioral seizures were induced. Different patterns of electrographical discharges as well as tonic-clonic convulsions were observed. The animals which were submitted to 3 stimulating sessions respectively 7, 14 and 21 days after surgery showed an increase in the epileptic activity. This has been interpreted as a plastic neural modification of the hippocampus similar to that observed during learning and memory consolidation. In comparison to other inducing kindling methods this one permits a more rapid elicitation of the phenomenon. For this reason this method will provide a good epilepsy model for the study of anticonvulsant drugs and basic mechanisms involved in the epileptic activity.