Remote ischemic preconditioning in myocardial protection in hemodialysis patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54321 http://dx.doi.org/10.2147/IJGM.S144385 |
Resumo: | Background: Remote ischemic preconditioning (RIPC) is a procedure that generates a brief period of ischemia followed by reperfusion. The role of RIPC in protecting myocardial ischemia during hemodialysis is not yet established. The aim of the study was to evaluate RIPC myocardial protection as evaluated by ultrasensitive I troponin in hemodialysis outpatients. Patients and methods: A double-blind randomized trial with two groups: intervention submitted to RIPC and control group without RIPC. Intervention group received RIPC in three consecutive hemodialysis sessions. Blood samples were taken before and after each session. Blood urea nitrogen for calculation of single-pool Kt/v and ultrasensitive I troponin were measured to evaluate dialysis adequacy and myocardial injury. Results: A total of 47 patients were randomized. About 60.8% were men and 54% were diabetic. The mean single-pool Kt/v was 1.51 in the intervention group and 1.49 in control. The ultrasensitive troponin I measured no significant change from the time of collection: before or after dialysis. Conclusion: The RIPC applied in three consecutive sessions did not demonstrate superiority to control, therefore another study tested RIPC in 12 consecutive sessions with a positive result in myocardial protection. In our study, more than half of the patients were diabetic. Diabetic patients have a trend to show a lower response to RIPC because of the greater presence of collateral coronary circulation. In summary, in this model there was no interference of RIPC in ultrasensitive troponin I values, but troponin had a high negative predictive value for myocardial infarction in all tested models. |
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Bacci, Marcelo R.Vasconcelos, Livia Y.Murad, NeifChagas, Antonio Carlos P.Capuano, Ana CarolinaAlves, Beatriz C. A.Pereira, Edimar C. [UNIFESP]Azzalis, Ligia A. [UNIFESP]Junqueira, Virginia B. C. [UNIFESP]Fonseca, Fernando L. A. [UNIFESP]2020-07-08T13:09:57Z2020-07-08T13:09:57Z2018International Journal Of General Medicine. Albany, v. 11, p. 175-178, 2018.1178-7074https://repositorio.unifesp.br/handle/11600/54321http://dx.doi.org/10.2147/IJGM.S144385WOS000431661700001.pdf10.2147/IJGM.S144385WOS:000431661700001Background: Remote ischemic preconditioning (RIPC) is a procedure that generates a brief period of ischemia followed by reperfusion. The role of RIPC in protecting myocardial ischemia during hemodialysis is not yet established. The aim of the study was to evaluate RIPC myocardial protection as evaluated by ultrasensitive I troponin in hemodialysis outpatients. Patients and methods: A double-blind randomized trial with two groups: intervention submitted to RIPC and control group without RIPC. Intervention group received RIPC in three consecutive hemodialysis sessions. Blood samples were taken before and after each session. Blood urea nitrogen for calculation of single-pool Kt/v and ultrasensitive I troponin were measured to evaluate dialysis adequacy and myocardial injury. Results: A total of 47 patients were randomized. About 60.8% were men and 54% were diabetic. The mean single-pool Kt/v was 1.51 in the intervention group and 1.49 in control. The ultrasensitive troponin I measured no significant change from the time of collection: before or after dialysis. Conclusion: The RIPC applied in three consecutive sessions did not demonstrate superiority to control, therefore another study tested RIPC in 12 consecutive sessions with a positive result in myocardial protection. In our study, more than half of the patients were diabetic. Diabetic patients have a trend to show a lower response to RIPC because of the greater presence of collateral coronary circulation. In summary, in this model there was no interference of RIPC in ultrasensitive troponin I values, but troponin had a high negative predictive value for myocardial infarction in all tested models.ABC, Fac Med, Dept Gen Practice, Av Principe Gales N 821, BR-09060650 Santo Andre, SP, BrazilABC, Fac Med, Dept Cardiol, Santo Andre, SP, BrazilABC, Fac Med, Clin Anal Lab, Santo Andre, SP, BrazilUniv Fed Sao Paulo, Dept Pharmaceut Sci, Diadema, SP, BrazilUniv Fed Sao Paulo, Dept Pharmaceut Sci, Diadema, SP, BrazilWeb of Science175-178engDove Medical Press LtdInternational Journal Of General Medicinehemodialysischronic kidney diseasecardiac troponinremote ischemic preconditioningmyocardial infarctionRemote ischemic preconditioning in myocardial protection in hemodialysis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAlbany11info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000431661700001.pdfapplication/pdf133319${dspace.ui.url}/bitstream/11600/54321/1/WOS000431661700001.pdf6d043b1dc0b37f27fa0b97cd42f6a83bMD51open accessTEXTWOS000431661700001.pdf.txtWOS000431661700001.pdf.txtExtracted texttext/plain19567${dspace.ui.url}/bitstream/11600/54321/8/WOS000431661700001.pdf.txtfae141c2fbbad84d12b72b94aa883ab2MD58open accessTHUMBNAILWOS000431661700001.pdf.jpgWOS000431661700001.pdf.jpgIM Thumbnailimage/jpeg6994${dspace.ui.url}/bitstream/11600/54321/10/WOS000431661700001.pdf.jpg340b9555daf288d1a14c3fc85779d04bMD510open access11600/543212023-06-05 19:26:58.787open accessoai:repositorio.unifesp.br:11600/54321Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:26:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Remote ischemic preconditioning in myocardial protection in hemodialysis patients |
title |
Remote ischemic preconditioning in myocardial protection in hemodialysis patients |
spellingShingle |
Remote ischemic preconditioning in myocardial protection in hemodialysis patients Bacci, Marcelo R. hemodialysis chronic kidney disease cardiac troponin remote ischemic preconditioning myocardial infarction |
title_short |
Remote ischemic preconditioning in myocardial protection in hemodialysis patients |
title_full |
Remote ischemic preconditioning in myocardial protection in hemodialysis patients |
title_fullStr |
Remote ischemic preconditioning in myocardial protection in hemodialysis patients |
title_full_unstemmed |
Remote ischemic preconditioning in myocardial protection in hemodialysis patients |
title_sort |
Remote ischemic preconditioning in myocardial protection in hemodialysis patients |
author |
Bacci, Marcelo R. |
author_facet |
Bacci, Marcelo R. Vasconcelos, Livia Y. Murad, Neif Chagas, Antonio Carlos P. Capuano, Ana Carolina Alves, Beatriz C. A. Pereira, Edimar C. [UNIFESP] Azzalis, Ligia A. [UNIFESP] Junqueira, Virginia B. C. [UNIFESP] Fonseca, Fernando L. A. [UNIFESP] |
author_role |
author |
author2 |
Vasconcelos, Livia Y. Murad, Neif Chagas, Antonio Carlos P. Capuano, Ana Carolina Alves, Beatriz C. A. Pereira, Edimar C. [UNIFESP] Azzalis, Ligia A. [UNIFESP] Junqueira, Virginia B. C. [UNIFESP] Fonseca, Fernando L. A. [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bacci, Marcelo R. Vasconcelos, Livia Y. Murad, Neif Chagas, Antonio Carlos P. Capuano, Ana Carolina Alves, Beatriz C. A. Pereira, Edimar C. [UNIFESP] Azzalis, Ligia A. [UNIFESP] Junqueira, Virginia B. C. [UNIFESP] Fonseca, Fernando L. A. [UNIFESP] |
dc.subject.eng.fl_str_mv |
hemodialysis chronic kidney disease cardiac troponin remote ischemic preconditioning myocardial infarction |
topic |
hemodialysis chronic kidney disease cardiac troponin remote ischemic preconditioning myocardial infarction |
description |
Background: Remote ischemic preconditioning (RIPC) is a procedure that generates a brief period of ischemia followed by reperfusion. The role of RIPC in protecting myocardial ischemia during hemodialysis is not yet established. The aim of the study was to evaluate RIPC myocardial protection as evaluated by ultrasensitive I troponin in hemodialysis outpatients. Patients and methods: A double-blind randomized trial with two groups: intervention submitted to RIPC and control group without RIPC. Intervention group received RIPC in three consecutive hemodialysis sessions. Blood samples were taken before and after each session. Blood urea nitrogen for calculation of single-pool Kt/v and ultrasensitive I troponin were measured to evaluate dialysis adequacy and myocardial injury. Results: A total of 47 patients were randomized. About 60.8% were men and 54% were diabetic. The mean single-pool Kt/v was 1.51 in the intervention group and 1.49 in control. The ultrasensitive troponin I measured no significant change from the time of collection: before or after dialysis. Conclusion: The RIPC applied in three consecutive sessions did not demonstrate superiority to control, therefore another study tested RIPC in 12 consecutive sessions with a positive result in myocardial protection. In our study, more than half of the patients were diabetic. Diabetic patients have a trend to show a lower response to RIPC because of the greater presence of collateral coronary circulation. In summary, in this model there was no interference of RIPC in ultrasensitive troponin I values, but troponin had a high negative predictive value for myocardial infarction in all tested models. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-07-08T13:09:57Z |
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2020-07-08T13:09:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
International Journal Of General Medicine. Albany, v. 11, p. 175-178, 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/54321 http://dx.doi.org/10.2147/IJGM.S144385 |
dc.identifier.issn.none.fl_str_mv |
1178-7074 |
dc.identifier.file.none.fl_str_mv |
WOS000431661700001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.2147/IJGM.S144385 |
dc.identifier.wos.none.fl_str_mv |
WOS:000431661700001 |
identifier_str_mv |
International Journal Of General Medicine. Albany, v. 11, p. 175-178, 2018. 1178-7074 WOS000431661700001.pdf 10.2147/IJGM.S144385 WOS:000431661700001 |
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https://repositorio.unifesp.br/handle/11600/54321 http://dx.doi.org/10.2147/IJGM.S144385 |
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eng |
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International Journal Of General Medicine |
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175-178 |
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Albany |
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Dove Medical Press Ltd |
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Dove Medical Press Ltd |
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