Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment

Detalhes bibliográficos
Autor(a) principal: Cividanes, Giuliana C.
Data de Publicação: 2014
Outros Autores: Mello, Andrea Feijó, Sallum, Juliana M., Fossaluza, Victor, Medeiros, Marcio de, Maciel, Mariana R., Cavalcante-Nóbrega, Luciana Porto [UNIFESP], Mari, Jair de Jesus [UNIFESP], Mello, Marcelo Feijó de [UNIFESP], Valentte, Nina L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/1516-4446-2013-1150
http://repositorio.unifesp.br/handle/11600/8677
Resumo: Objective: To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence. Methods: Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes. Results: One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence. Conclusions: Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk.
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spelling Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatmentSerotonin transporter polymorphismchild maltreatmentchild laborstreet childrenObjective: To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence. Methods: Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes. Results: One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence. Conclusions: Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk.Universidade Federal de São Paulo (UNIFESP) Department of PsychiatryOcular Genetic InstituteCollege of Public Health, USPUniversidade de São Paulo (USP) Institute of Mathematics and StatisticsKing's College London Institute of Psychiatry Health Service and Population Research DepartmentUNIFESP, Department of PsychiatrySciELOAssociação Brasileira de Psiquiatria - ABPUniversidade Federal de São Paulo (UNIFESP)Ocular Genetic InstituteUniversidade de São Paulo (USP)King's College London Institute of Psychiatry Health Service and Population Research DepartmentCividanes, Giuliana C.Mello, Andrea FeijóSallum, Juliana M.Fossaluza, VictorMedeiros, Marcio deMaciel, Mariana R.Cavalcante-Nóbrega, Luciana Porto [UNIFESP]Mari, Jair de Jesus [UNIFESP]Mello, Marcelo Feijó de [UNIFESP]Valentte, Nina L.2015-06-14T13:47:23Z2015-06-14T13:47:23Z2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion277-284application/pdfhttp://dx.doi.org/10.1590/1516-4446-2013-1150Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 4, p. 277-284, 2014.10.1590/1516-4446-2013-1150S1516-44462014000500277.pdf1516-4446S1516-44462014000500277http://repositorio.unifesp.br/handle/11600/8677engRevista Brasileira de Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T01:45:39Zoai:repositorio.unifesp.br/:11600/8677Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:05:38.550966Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
title Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
spellingShingle Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
Cividanes, Giuliana C.
Serotonin transporter polymorphism
child maltreatment
child labor
street children
title_short Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
title_full Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
title_fullStr Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
title_full_unstemmed Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
title_sort Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
author Cividanes, Giuliana C.
author_facet Cividanes, Giuliana C.
Mello, Andrea Feijó
Sallum, Juliana M.
Fossaluza, Victor
Medeiros, Marcio de
Maciel, Mariana R.
Cavalcante-Nóbrega, Luciana Porto [UNIFESP]
Mari, Jair de Jesus [UNIFESP]
Mello, Marcelo Feijó de [UNIFESP]
Valentte, Nina L.
author_role author
author2 Mello, Andrea Feijó
Sallum, Juliana M.
Fossaluza, Victor
Medeiros, Marcio de
Maciel, Mariana R.
Cavalcante-Nóbrega, Luciana Porto [UNIFESP]
Mari, Jair de Jesus [UNIFESP]
Mello, Marcelo Feijó de [UNIFESP]
Valentte, Nina L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Ocular Genetic Institute
Universidade de São Paulo (USP)
King's College London Institute of Psychiatry Health Service and Population Research Department
dc.contributor.author.fl_str_mv Cividanes, Giuliana C.
Mello, Andrea Feijó
Sallum, Juliana M.
Fossaluza, Victor
Medeiros, Marcio de
Maciel, Mariana R.
Cavalcante-Nóbrega, Luciana Porto [UNIFESP]
Mari, Jair de Jesus [UNIFESP]
Mello, Marcelo Feijó de [UNIFESP]
Valentte, Nina L.
dc.subject.por.fl_str_mv Serotonin transporter polymorphism
child maltreatment
child labor
street children
topic Serotonin transporter polymorphism
child maltreatment
child labor
street children
description Objective: To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence. Methods: Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes. Results: One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence. Conclusions: Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
2015-06-14T13:47:23Z
2015-06-14T13:47:23Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1516-4446-2013-1150
Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 4, p. 277-284, 2014.
10.1590/1516-4446-2013-1150
S1516-44462014000500277.pdf
1516-4446
S1516-44462014000500277
http://repositorio.unifesp.br/handle/11600/8677
url http://dx.doi.org/10.1590/1516-4446-2013-1150
http://repositorio.unifesp.br/handle/11600/8677
identifier_str_mv Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 4, p. 277-284, 2014.
10.1590/1516-4446-2013-1150
S1516-44462014000500277.pdf
1516-4446
S1516-44462014000500277
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira de Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 277-284
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria - ABP
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria - ABP
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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