Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/1516-4446-2013-1150 http://repositorio.unifesp.br/handle/11600/8677 |
Resumo: | Objective: To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence. Methods: Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes. Results: One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence. Conclusions: Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk. |
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Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatmentSerotonin transporter polymorphismchild maltreatmentchild laborstreet childrenObjective: To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence. Methods: Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes. Results: One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence. Conclusions: Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk.Universidade Federal de São Paulo (UNIFESP) Department of PsychiatryOcular Genetic InstituteCollege of Public Health, USPUniversidade de São Paulo (USP) Institute of Mathematics and StatisticsKing's College London Institute of Psychiatry Health Service and Population Research DepartmentUNIFESP, Department of PsychiatrySciELOAssociação Brasileira de Psiquiatria - ABPUniversidade Federal de São Paulo (UNIFESP)Ocular Genetic InstituteUniversidade de São Paulo (USP)King's College London Institute of Psychiatry Health Service and Population Research DepartmentCividanes, Giuliana C.Mello, Andrea FeijóSallum, Juliana M.Fossaluza, VictorMedeiros, Marcio deMaciel, Mariana R.Cavalcante-Nóbrega, Luciana Porto [UNIFESP]Mari, Jair de Jesus [UNIFESP]Mello, Marcelo Feijó de [UNIFESP]Valentte, Nina L.2015-06-14T13:47:23Z2015-06-14T13:47:23Z2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion277-284application/pdfhttp://dx.doi.org/10.1590/1516-4446-2013-1150Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 4, p. 277-284, 2014.10.1590/1516-4446-2013-1150S1516-44462014000500277.pdf1516-4446S1516-44462014000500277http://repositorio.unifesp.br/handle/11600/8677engRevista Brasileira de Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T01:45:39Zoai:repositorio.unifesp.br/:11600/8677Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:05:38.550966Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment |
title |
Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment |
spellingShingle |
Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment Cividanes, Giuliana C. Serotonin transporter polymorphism child maltreatment child labor street children |
title_short |
Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment |
title_full |
Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment |
title_fullStr |
Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment |
title_full_unstemmed |
Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment |
title_sort |
Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment |
author |
Cividanes, Giuliana C. |
author_facet |
Cividanes, Giuliana C. Mello, Andrea Feijó Sallum, Juliana M. Fossaluza, Victor Medeiros, Marcio de Maciel, Mariana R. Cavalcante-Nóbrega, Luciana Porto [UNIFESP] Mari, Jair de Jesus [UNIFESP] Mello, Marcelo Feijó de [UNIFESP] Valentte, Nina L. |
author_role |
author |
author2 |
Mello, Andrea Feijó Sallum, Juliana M. Fossaluza, Victor Medeiros, Marcio de Maciel, Mariana R. Cavalcante-Nóbrega, Luciana Porto [UNIFESP] Mari, Jair de Jesus [UNIFESP] Mello, Marcelo Feijó de [UNIFESP] Valentte, Nina L. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Ocular Genetic Institute Universidade de São Paulo (USP) King's College London Institute of Psychiatry Health Service and Population Research Department |
dc.contributor.author.fl_str_mv |
Cividanes, Giuliana C. Mello, Andrea Feijó Sallum, Juliana M. Fossaluza, Victor Medeiros, Marcio de Maciel, Mariana R. Cavalcante-Nóbrega, Luciana Porto [UNIFESP] Mari, Jair de Jesus [UNIFESP] Mello, Marcelo Feijó de [UNIFESP] Valentte, Nina L. |
dc.subject.por.fl_str_mv |
Serotonin transporter polymorphism child maltreatment child labor street children |
topic |
Serotonin transporter polymorphism child maltreatment child labor street children |
description |
Objective: To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence. Methods: Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes. Results: One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence. Conclusions: Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 2015-06-14T13:47:23Z 2015-06-14T13:47:23Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1516-4446-2013-1150 Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 4, p. 277-284, 2014. 10.1590/1516-4446-2013-1150 S1516-44462014000500277.pdf 1516-4446 S1516-44462014000500277 http://repositorio.unifesp.br/handle/11600/8677 |
url |
http://dx.doi.org/10.1590/1516-4446-2013-1150 http://repositorio.unifesp.br/handle/11600/8677 |
identifier_str_mv |
Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 4, p. 277-284, 2014. 10.1590/1516-4446-2013-1150 S1516-44462014000500277.pdf 1516-4446 S1516-44462014000500277 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
277-284 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria - ABP |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria - ABP |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1818379249213505536 |