Freqüência de doença cardiovascular aterosclerótica e de seus fatores de risco em pacientes com lúpus eritematoso sistêmico

• Autor(a) principal: Telles, Rosa Weiss
• Data de Publicação: 2007
• Outros Autores: Lanna, Cristina Costa Duarte, Ferreira, Gilda Aparecida [UNIFESP], Carvalho, Marco Antonio Parreiras De, Ribeiro, Antonio Luiz
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0482-50042007000300005; http://repositorio.unifesp.br/handle/11600/3778
• topic: systemic lupus erythematosus; atherosclerosis; risk factors for coronary disease; cardiovascular disease; lúpus eritematoso sistêmico; aterosclerose; fatores de risco; doença cardiovascular

INTRODUCTION: the pathogenesis of coronary disease in systemic lupus erythematosus patients is not completely understood. Risk factors associated with lupus or its treatment may be associated with traditional risk factors for coronary disease. Such risk factors are more common in patients with lupus. OBJECTIVE: to determine the frequency of cardiovascular disease and traditional risk factors in patients with systemic lupus erythematosus at Rheumatology Division of Hospital das Clínicas of Minas Gerais Federal University. METHODS: 172 patients with systemic lupus erythematosus were evaluated. Cardiovascular events, traditional risk factors and clinical-laboratorial findings were investigated in this cross-sectional research. RESULTS: the mean age (SD) of the patients was 38.5 years (11.2 years). 95.9% were female and 64.5% were non white. Cardiovascular disease was identified in 8 patients (4.7%), with 11 different diagnoses. Three patients had coronary insufficiency, three had stroke and five had peripheral arterial disease. Systemic arterial hypertension was the most frequent risk factor (48.8%), followed by dyslipidemia in 70 patients (40.7%) and hypertriglyceridemia in 51 patients (29.7%). LDL-c > 100 mg/dl was found in 77 patients (44.8%). Among 165 female patients, 67 (40.6%) had menopause, 43.3% of them with early menopause. CONCLUSION: the present study describes the frequency of risk factors for coronary artery disease in a Brazilian sample of lupus patients. The impact of recognition and management of those risk factors in prevention of cardiovascular events should be object of others studies.