The emerging role of mirnas and their clinical implication in biliary tract cancer

Detalhes bibliográficos
Autor(a) principal: Ferreira Martins, Nina Nayara
Data de Publicação: 2016
Outros Autores: da Silva Oliveira, Kelly Cristina, Bona, Amanda Braga, Cardoso Smith, Marilia de Arruda [UNIFESP], Ishak, Geraldo, Assumpcao, Paulo Pimentel, Burbano, Rommel Rodriguez, Calcagno, Danielle Queiroz
Tipo de documento: Artigo (review)
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1155/2016/9797410
http://repositorio.unifesp.br/handle/11600/49276
Resumo: Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra-and extrahepatic ducts and have a poor prognosis. Surgical resection remains themain curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several singlenucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.
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spelling The emerging role of mirnas and their clinical implication in biliary tract cancerIntrahepatic Cholangiocarcinoma CellsNorth Indian PopulationGallbladder CancerTumor-SuppressorGastric-CancerGenetic-VariantsMesenchymal TransitionEpigenetic RegulationDown-RegulationC-MycBiliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra-and extrahepatic ducts and have a poor prognosis. Surgical resection remains themain curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several singlenucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, BrazilLaboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, BrazilUniversidade Federal de São Paulo, São Paulo, SP, BrazilUniversidade Federal de São Paulo, São Paulo, SP, BrazilWeb of ScienceFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Editora Unilasalle2019-01-21T10:29:34Z2019-01-21T10:29:34Z2016info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://dx.doi.org/10.1155/2016/9797410Gastroenterology Research And Practice. New york, 2016.10.1155/2016/9797410WOS000392001900001.pdf1687-6121http://repositorio.unifesp.br/handle/11600/49276WOS:000392001900001engGastroenterology Research And Practiceinfo:eu-repo/semantics/openAccessFerreira Martins, Nina Nayarada Silva Oliveira, Kelly CristinaBona, Amanda BragaCardoso Smith, Marilia de Arruda [UNIFESP]Ishak, GeraldoAssumpcao, Paulo PimentelBurbano, Rommel RodriguezCalcagno, Danielle Queirozreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-10T00:48:56Zoai:repositorio.unifesp.br/:11600/49276Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-10T00:48:56Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv The emerging role of mirnas and their clinical implication in biliary tract cancer
title The emerging role of mirnas and their clinical implication in biliary tract cancer
spellingShingle The emerging role of mirnas and their clinical implication in biliary tract cancer
Ferreira Martins, Nina Nayara
Intrahepatic Cholangiocarcinoma Cells
North Indian Population
Gallbladder Cancer
Tumor-Suppressor
Gastric-Cancer
Genetic-Variants
Mesenchymal Transition
Epigenetic Regulation
Down-Regulation
C-Myc
title_short The emerging role of mirnas and their clinical implication in biliary tract cancer
title_full The emerging role of mirnas and their clinical implication in biliary tract cancer
title_fullStr The emerging role of mirnas and their clinical implication in biliary tract cancer
title_full_unstemmed The emerging role of mirnas and their clinical implication in biliary tract cancer
title_sort The emerging role of mirnas and their clinical implication in biliary tract cancer
author Ferreira Martins, Nina Nayara
author_facet Ferreira Martins, Nina Nayara
da Silva Oliveira, Kelly Cristina
Bona, Amanda Braga
Cardoso Smith, Marilia de Arruda [UNIFESP]
Ishak, Geraldo
Assumpcao, Paulo Pimentel
Burbano, Rommel Rodriguez
Calcagno, Danielle Queiroz
author_role author
author2 da Silva Oliveira, Kelly Cristina
Bona, Amanda Braga
Cardoso Smith, Marilia de Arruda [UNIFESP]
Ishak, Geraldo
Assumpcao, Paulo Pimentel
Burbano, Rommel Rodriguez
Calcagno, Danielle Queiroz
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira Martins, Nina Nayara
da Silva Oliveira, Kelly Cristina
Bona, Amanda Braga
Cardoso Smith, Marilia de Arruda [UNIFESP]
Ishak, Geraldo
Assumpcao, Paulo Pimentel
Burbano, Rommel Rodriguez
Calcagno, Danielle Queiroz
dc.subject.por.fl_str_mv Intrahepatic Cholangiocarcinoma Cells
North Indian Population
Gallbladder Cancer
Tumor-Suppressor
Gastric-Cancer
Genetic-Variants
Mesenchymal Transition
Epigenetic Regulation
Down-Regulation
C-Myc
topic Intrahepatic Cholangiocarcinoma Cells
North Indian Population
Gallbladder Cancer
Tumor-Suppressor
Gastric-Cancer
Genetic-Variants
Mesenchymal Transition
Epigenetic Regulation
Down-Regulation
C-Myc
description Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra-and extrahepatic ducts and have a poor prognosis. Surgical resection remains themain curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several singlenucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019-01-21T10:29:34Z
2019-01-21T10:29:34Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/review
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format review
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2016/9797410
Gastroenterology Research And Practice. New york, 2016.
10.1155/2016/9797410
WOS000392001900001.pdf
1687-6121
http://repositorio.unifesp.br/handle/11600/49276
WOS:000392001900001
url http://dx.doi.org/10.1155/2016/9797410
http://repositorio.unifesp.br/handle/11600/49276
identifier_str_mv Gastroenterology Research And Practice. New york, 2016.
10.1155/2016/9797410
WOS000392001900001.pdf
1687-6121
WOS:000392001900001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gastroenterology Research And Practice
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora Unilasalle
publisher.none.fl_str_mv Editora Unilasalle
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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