Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough?
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/42880 http://dx.doi.org/10.1590/S1413-86702007000400009 |
Resumo: | We evaluated the performance of several methods for the detection of methicillin resistance in Staphylococcus aureus using 101 clinical S. aureus isolates from pediatric patients in a tertiary hospital in Brazil; 50 isolates were mecA-positive and 51 were mecA-negative. The Etest and oxacillin agar screening plates were 100% sensitive and specific for mecA presence. Oxacillin and cefoxitin disks gave sensitivities of 96 and 92%, respectively, and 98% specificity. Alterations of CLSI cefoxitin breakpoints increased sensitivity to 98%, without decreasing specificity. Our results highlight the importance of a continuing evaluation of the recommended microbiological methods by different laboratories and in different settings. If necessary, laboratories should use a second test before reporting a strain as susceptible, especially when testing strains isolated from invasive or serious infections. With the new (2007) CLSI breakpoints, the cefoxitin-disk test appears to be a good option for the detection of methicillin resistance in S. aureus. |
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Mimica, M. J.Berezin, Eitan Naaman [UNIFESP]Carvalho, R. L. B.Mimica, I. M.Mimica, L. M. J.Safadi, Marco Aurelio Palazzi [UNIFESP]Schneider, E.Caiaffa-Filho, H. H.Universidade Federal de São Paulo (UNIFESP)Santa Casa Univ HospUniversidade de São Paulo (USP)2018-06-15T14:04:33Z2018-06-15T14:04:33Z2007-08-01Brazilian Journal Of Infectious Diseases. Salvador: Contexto, v. 11, n. 4, p. 415-417, 2007.1413-8670http://repositorio.unifesp.br/11600/42880http://dx.doi.org/10.1590/S1413-86702007000400009S1413-86702007000400009.pdfS1413-8670200700040000910.1590/S1413-86702007000400009WOS:000254388600009We evaluated the performance of several methods for the detection of methicillin resistance in Staphylococcus aureus using 101 clinical S. aureus isolates from pediatric patients in a tertiary hospital in Brazil; 50 isolates were mecA-positive and 51 were mecA-negative. The Etest and oxacillin agar screening plates were 100% sensitive and specific for mecA presence. Oxacillin and cefoxitin disks gave sensitivities of 96 and 92%, respectively, and 98% specificity. Alterations of CLSI cefoxitin breakpoints increased sensitivity to 98%, without decreasing specificity. Our results highlight the importance of a continuing evaluation of the recommended microbiological methods by different laboratories and in different settings. If necessary, laboratories should use a second test before reporting a strain as susceptible, especially when testing strains isolated from invasive or serious infections. With the new (2007) CLSI breakpoints, the cefoxitin-disk test appears to be a good option for the detection of methicillin resistance in S. aureus.Dept Pediat, Div Pediat Infect Dis, Sao Paulo, BrazilSanta Casa Univ Hosp, Dept Pathol, Microbiol Lab, Sao Paulo, BrazilFMUSP, Hosp Clin, LIM 03, Sao Paulo, BrazilWeb of Science415-417engContextoBrazilian Journal Of Infectious DiseasesMRSAdisc diffusioncefoxitinmecADetection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/428802021-10-05 22:02:41.259metadata only accessoai:repositorio.unifesp.br:11600/42880Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:18:33.242324Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough? |
title |
Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough? |
spellingShingle |
Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough? Mimica, M. J. MRSA disc diffusion cefoxitin mecA |
title_short |
Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough? |
title_full |
Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough? |
title_fullStr |
Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough? |
title_full_unstemmed |
Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough? |
title_sort |
Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: Is the cefoxitin disk diffusion test accurate enough? |
author |
Mimica, M. J. |
author_facet |
Mimica, M. J. Berezin, Eitan Naaman [UNIFESP] Carvalho, R. L. B. Mimica, I. M. Mimica, L. M. J. Safadi, Marco Aurelio Palazzi [UNIFESP] Schneider, E. Caiaffa-Filho, H. H. |
author_role |
author |
author2 |
Berezin, Eitan Naaman [UNIFESP] Carvalho, R. L. B. Mimica, I. M. Mimica, L. M. J. Safadi, Marco Aurelio Palazzi [UNIFESP] Schneider, E. Caiaffa-Filho, H. H. |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Santa Casa Univ Hosp Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Mimica, M. J. Berezin, Eitan Naaman [UNIFESP] Carvalho, R. L. B. Mimica, I. M. Mimica, L. M. J. Safadi, Marco Aurelio Palazzi [UNIFESP] Schneider, E. Caiaffa-Filho, H. H. |
dc.subject.eng.fl_str_mv |
MRSA disc diffusion cefoxitin mecA |
topic |
MRSA disc diffusion cefoxitin mecA |
description |
We evaluated the performance of several methods for the detection of methicillin resistance in Staphylococcus aureus using 101 clinical S. aureus isolates from pediatric patients in a tertiary hospital in Brazil; 50 isolates were mecA-positive and 51 were mecA-negative. The Etest and oxacillin agar screening plates were 100% sensitive and specific for mecA presence. Oxacillin and cefoxitin disks gave sensitivities of 96 and 92%, respectively, and 98% specificity. Alterations of CLSI cefoxitin breakpoints increased sensitivity to 98%, without decreasing specificity. Our results highlight the importance of a continuing evaluation of the recommended microbiological methods by different laboratories and in different settings. If necessary, laboratories should use a second test before reporting a strain as susceptible, especially when testing strains isolated from invasive or serious infections. With the new (2007) CLSI breakpoints, the cefoxitin-disk test appears to be a good option for the detection of methicillin resistance in S. aureus. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-08-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T14:04:33Z |
dc.date.available.fl_str_mv |
2018-06-15T14:04:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal Of Infectious Diseases. Salvador: Contexto, v. 11, n. 4, p. 415-417, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/42880 http://dx.doi.org/10.1590/S1413-86702007000400009 |
dc.identifier.issn.none.fl_str_mv |
1413-8670 |
dc.identifier.file.none.fl_str_mv |
S1413-86702007000400009.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1413-86702007000400009 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1413-86702007000400009 |
dc.identifier.wos.none.fl_str_mv |
WOS:000254388600009 |
identifier_str_mv |
Brazilian Journal Of Infectious Diseases. Salvador: Contexto, v. 11, n. 4, p. 415-417, 2007. 1413-8670 S1413-86702007000400009.pdf S1413-86702007000400009 10.1590/S1413-86702007000400009 WOS:000254388600009 |
url |
http://repositorio.unifesp.br/11600/42880 http://dx.doi.org/10.1590/S1413-86702007000400009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Brazilian Journal Of Infectious Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
415-417 |
dc.publisher.none.fl_str_mv |
Contexto |
publisher.none.fl_str_mv |
Contexto |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460274884313088 |