Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity

Detalhes bibliográficos
Autor(a) principal: Sader, Helio S. [UNIFESP]
Data de Publicação: 2004
Outros Autores: Fedler, Kelley A., Rennie, Robert P., Stevens, Shelley, Jones, Ronald N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1128/AAC.48.8.312-3118.2004
http://repositorio.unifesp.br/handle/11600/27844
Resumo: The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. the omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.
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spelling Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activityThe activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. the omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.JMI Labs, Jones Grp, N Liberty, IA 52317 USAUniversidade Federal de São Paulo, São Paulo, BrazilUniv Alberta Hosp, Edmonton, AB T6G 2B7, CanadaUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of ScienceAmer Soc MicrobiologyJMI LabsUniversidade Federal de São Paulo (UNIFESP)Univ Alberta HospSader, Helio S. [UNIFESP]Fedler, Kelley A.Rennie, Robert P.Stevens, ShelleyJones, Ronald N.2016-01-24T12:37:16Z2016-01-24T12:37:16Z2004-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion3112-3118application/pdfhttp://dx.doi.org/10.1128/AAC.48.8.312-3118.2004Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 48, n. 8, p. 3112-3118, 2004.10.1128/AAC.48.8.312-3118.2004WOS000222998300047.pdf0066-4804http://repositorio.unifesp.br/handle/11600/27844WOS:000222998300047engAntimicrobial Agents and Chemotherapyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T03:04:10Zoai:repositorio.unifesp.br/:11600/27844Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T03:04:10Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
spellingShingle Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
Sader, Helio S. [UNIFESP]
title_short Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title_full Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title_fullStr Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title_full_unstemmed Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title_sort Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
author Sader, Helio S. [UNIFESP]
author_facet Sader, Helio S. [UNIFESP]
Fedler, Kelley A.
Rennie, Robert P.
Stevens, Shelley
Jones, Ronald N.
author_role author
author2 Fedler, Kelley A.
Rennie, Robert P.
Stevens, Shelley
Jones, Ronald N.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv JMI Labs
Universidade Federal de São Paulo (UNIFESP)
Univ Alberta Hosp
dc.contributor.author.fl_str_mv Sader, Helio S. [UNIFESP]
Fedler, Kelley A.
Rennie, Robert P.
Stevens, Shelley
Jones, Ronald N.
description The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. the omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.
publishDate 2004
dc.date.none.fl_str_mv 2004-08-01
2016-01-24T12:37:16Z
2016-01-24T12:37:16Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1128/AAC.48.8.312-3118.2004
Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 48, n. 8, p. 3112-3118, 2004.
10.1128/AAC.48.8.312-3118.2004
WOS000222998300047.pdf
0066-4804
http://repositorio.unifesp.br/handle/11600/27844
WOS:000222998300047
url http://dx.doi.org/10.1128/AAC.48.8.312-3118.2004
http://repositorio.unifesp.br/handle/11600/27844
identifier_str_mv Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 48, n. 8, p. 3112-3118, 2004.
10.1128/AAC.48.8.312-3118.2004
WOS000222998300047.pdf
0066-4804
WOS:000222998300047
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antimicrobial Agents and Chemotherapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3112-3118
application/pdf
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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