Síndrome de Guillain-Barré em associação temporal com a vacina influenza A

• Autor(a) principal: Ferrarini, Maria Aparecida G [UNIFESP]
• Data de Publicação: 2011
• Outros Autores: Scattolin, Mônica Ayres A, Masruha, Marcelo Rodrigues [UNIFESP], Resende, Maura Helena F, Santos, Isabel Cristina L. Dos, Iazzetti, Antônio Vladir [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0103-05822011000400033; http://repositorio.unifesp.br/handle/11600/6721
• topic: influenza vaccines; adverse effects; Guillain-Barre syndrome; influenza; prevention & control; vacinas contra influenza; efeitos adversos; síndrome de Guillain-Barré; influenza; prevenção & controle

OBJECTIVE: To report a case of Guillain-Barré syndrome following influenza A (H1N1) 2009 vaccine. CASE DESCRIPTION: A four-year-old boy presented right thigh pain and ascending muscular weakness 15 days after the second dose of influenza A (H1N1) 2009 vaccine. The neurological examination revealed tetraparesis and areflexia. Electroneuromyography showed lower velocity and conduction blockage with small secondary axonal loss. Treated with intravenous immunoglobulin, the patient reached a plateau in the 4th day, followed by progressive muscular strength improvement. COMMENTS: The employment of large-scale influenza A (H1N1) 2009 vaccination and the preliminary reports from the American Surveillance Program suggest a significant association between Guillain-Barré syndrome and influenza A H1N1 2009 vaccination. All suspected cases of this association should be published for further evaluation. Vaccination remains the most effective method to prevent serious illness and death related to influenza.