Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.3748/wjg.v22.i35.7951 https://repositorio.unifesp.br/handle/11600/57102 |
| Resumo: | Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity. |
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Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancerGastric cancerEpigeneticDiagnostic biomarkersmiRNAsPrognostic biomarkersAlterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.Fed Univ Para, Hosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, 2 Piso UNACON,Av Mundurucus, BR-66073000 Belem, PA, BrazilUniv Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04021001 Sao Paulo, BrazilFed Univ Para, Lab Citogenet Humana, Inst Ciencias Biol, BR-66073000 Belem, PA, BrazilDisciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo 04021-001, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Baishideng Publishing Group Inc2020-07-31T12:47:48Z2020-07-31T12:47:48Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7951-7962application/pdfhttp://dx.doi.org/10.3748/wjg.v22.i35.7951World Journal Of Gastroenterology. Pleasanton, v. 22, n. 35, p. 7951-7962, 2016.10.3748/wjg.v22.i35.7951WOS000383981800008.pdf1007-9327https://repositorio.unifesp.br/handle/11600/57102WOS:000383981800008engWorld Journal Of GastroenterologyPleasantoninfo:eu-repo/semantics/openAccessda Silva Oliveira, Kelly CristinaThomaz Araujo, Taissa MairaAlbuquerque, Camila InagakiBarata, Gabriela AlcantaraGigek, Carolina Oliveira [UNIFESP]Leal, Mariana Ferreira [UNIFESP]Wisnieski, Fernanda [UNIFESP]Rodrigues Mello Junior, Fernando AugustoKhayat, Andre Salimde Assumpcao, Paulo PimentelRodriguez Burbano, Rommel MarioSmith, Marilia de Arruda Cardoso [UNIFESP]Calcagno, Danielle Queirozreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T19:38:33Zoai:repositorio.unifesp.br/:11600/57102Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T19:38:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer |
| title |
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer |
| spellingShingle |
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer da Silva Oliveira, Kelly Cristina Gastric cancer Epigenetic Diagnostic biomarkers miRNAs Prognostic biomarkers |
| title_short |
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer |
| title_full |
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer |
| title_fullStr |
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer |
| title_full_unstemmed |
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer |
| title_sort |
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer |
| author |
da Silva Oliveira, Kelly Cristina |
| author_facet |
da Silva Oliveira, Kelly Cristina Thomaz Araujo, Taissa Maira Albuquerque, Camila Inagaki Barata, Gabriela Alcantara Gigek, Carolina Oliveira [UNIFESP] Leal, Mariana Ferreira [UNIFESP] Wisnieski, Fernanda [UNIFESP] Rodrigues Mello Junior, Fernando Augusto Khayat, Andre Salim de Assumpcao, Paulo Pimentel Rodriguez Burbano, Rommel Mario Smith, Marilia de Arruda Cardoso [UNIFESP] Calcagno, Danielle Queiroz |
| author_role |
author |
| author2 |
Thomaz Araujo, Taissa Maira Albuquerque, Camila Inagaki Barata, Gabriela Alcantara Gigek, Carolina Oliveira [UNIFESP] Leal, Mariana Ferreira [UNIFESP] Wisnieski, Fernanda [UNIFESP] Rodrigues Mello Junior, Fernando Augusto Khayat, Andre Salim de Assumpcao, Paulo Pimentel Rodriguez Burbano, Rommel Mario Smith, Marilia de Arruda Cardoso [UNIFESP] Calcagno, Danielle Queiroz |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
da Silva Oliveira, Kelly Cristina Thomaz Araujo, Taissa Maira Albuquerque, Camila Inagaki Barata, Gabriela Alcantara Gigek, Carolina Oliveira [UNIFESP] Leal, Mariana Ferreira [UNIFESP] Wisnieski, Fernanda [UNIFESP] Rodrigues Mello Junior, Fernando Augusto Khayat, Andre Salim de Assumpcao, Paulo Pimentel Rodriguez Burbano, Rommel Mario Smith, Marilia de Arruda Cardoso [UNIFESP] Calcagno, Danielle Queiroz |
| dc.subject.por.fl_str_mv |
Gastric cancer Epigenetic Diagnostic biomarkers miRNAs Prognostic biomarkers |
| topic |
Gastric cancer Epigenetic Diagnostic biomarkers miRNAs Prognostic biomarkers |
| description |
Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2020-07-31T12:47:48Z 2020-07-31T12:47:48Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3748/wjg.v22.i35.7951 World Journal Of Gastroenterology. Pleasanton, v. 22, n. 35, p. 7951-7962, 2016. 10.3748/wjg.v22.i35.7951 WOS000383981800008.pdf 1007-9327 https://repositorio.unifesp.br/handle/11600/57102 WOS:000383981800008 |
| url |
http://dx.doi.org/10.3748/wjg.v22.i35.7951 https://repositorio.unifesp.br/handle/11600/57102 |
| identifier_str_mv |
World Journal Of Gastroenterology. Pleasanton, v. 22, n. 35, p. 7951-7962, 2016. 10.3748/wjg.v22.i35.7951 WOS000383981800008.pdf 1007-9327 WOS:000383981800008 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
World Journal Of Gastroenterology |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
7951-7962 application/pdf |
| dc.coverage.none.fl_str_mv |
Pleasanton |
| dc.publisher.none.fl_str_mv |
Baishideng Publishing Group Inc |
| publisher.none.fl_str_mv |
Baishideng Publishing Group Inc |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1827292195962486784 |
