The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats

Detalhes bibliográficos
Autor(a) principal: Ribeiro de Oliveira, Teresinha Regina [UNIFESP]
Data de Publicação: 2017
Outros Autores: de Oliveira, Geraldo Ferreira, Simoes, Ricardo Santos [UNIFESP], Tikazawa, Eduardo Hiroshi, Monteiro, Hugo Pequeno [UNIFESP], Fagundes, Djalma Jose [UNIFESP], Taha, Murched Omar [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/s0102-865020170070000007
https://repositorio.unifesp.br/handle/11600/53550
Resumo: Purpose: To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR). Methods: Thirty rats were assigned to 5 groups (N= 6): (CG): no clamping of the superior mesenteric artery (90 min.)
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spelling The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of ratsIschemic PreconditioningPentoxifyllineIschemiaReperfusion InjuryIntestinesRatsPurpose: To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR). Methods: Thirty rats were assigned to 5 groups (N= 6): (CG): no clamping of the superior mesenteric artery (90 min.)(IR-SS): saline + ischemia (30 min.) + reperfusion (60 min.)(IRPTX): PTX + ischemia (30min.) + reperfusion (60 min.)(IPC-IR-SS): 5 min. of ischemia + 5 minutes of reperfusion (IPC) + saline + ischemia (30 min.) + reperfusion (60 min.)(IPC-IR-PTX): 5 min. of ischemia + 5 min. of reperfusion (IPC) + PTX + 30 min. of I + 60 minutes of R. Results: The IR-PTX, IPC-IR-SS and IPC-IR-PTX groups had significantly lower scores of mucosa damage than the IR-SS group. IR-PTX group showed higher scores than the IPC-IR-PTX group, in accordance with the hypothesis of a favorable effect of IPC alone or in association with PTX. Additionally, IPC-IR-SS had a higher damage score than the IPC-IR-PTX. The villi height and crypt depth were similar in all groups. The villi height in the IR-SS was significantly lower. Conclusion: Ischemic preconditioning or pentoxifylline alone protect the intestinal mucosa from ischemia/reperfusion injury. However, they do not have a synergistic effect when applied together.UFGD, Sch Hlth Sci, Dourados, MS, BrazilUniv Sao Paulo UNIFESP, Dept Morfol & Genet, Sao Paulo, SP, BrazilUniv Estadual Campinas UNICAMP, Sch Med, Dept Publ Hlth, Publ Hlth, Campinas, SP, BrazilUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Surg, Div Surg Tech & Expt Surg, Sao Paulo, SP, BrazilUniv Sao Paulo UNIFESP, Dept Morfol & Genet, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Surg, Div Surg Tech & Expt Surg, Sao Paulo, SP, BrazilWeb of ScienceUFGD, Ministerio da Educacao do BrasilUFGD, Ministerio da Educacao do BrasilActa Cirurgica Brasileira2020-06-26T16:30:27Z2020-06-26T16:30:27Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion559-567application/pdfhttp://dx.doi.org/10.1590/s0102-865020170070000007Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 7, p. 559-567, 2017.10.1590/s0102-865020170070000007S0102-86502017000700559.pdf0102-8650S0102-86502017000700559https://repositorio.unifesp.br/handle/11600/53550WOS:000407368300007engActa Cirurgica BrasileiraSao Pauloinfo:eu-repo/semantics/openAccessRibeiro de Oliveira, Teresinha Regina [UNIFESP]de Oliveira, Geraldo FerreiraSimoes, Ricardo Santos [UNIFESP]Tikazawa, Eduardo HiroshiMonteiro, Hugo Pequeno [UNIFESP]Fagundes, Djalma Jose [UNIFESP]Taha, Murched Omar [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T03:34:06Zoai:repositorio.unifesp.br/:11600/53550Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T03:34:06Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
title The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
spellingShingle The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
Ribeiro de Oliveira, Teresinha Regina [UNIFESP]
Ischemic Preconditioning
Pentoxifylline
Ischemia
Reperfusion Injury
Intestines
Rats
title_short The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
title_full The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
title_fullStr The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
title_full_unstemmed The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
title_sort The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
author Ribeiro de Oliveira, Teresinha Regina [UNIFESP]
author_facet Ribeiro de Oliveira, Teresinha Regina [UNIFESP]
de Oliveira, Geraldo Ferreira
Simoes, Ricardo Santos [UNIFESP]
Tikazawa, Eduardo Hiroshi
Monteiro, Hugo Pequeno [UNIFESP]
Fagundes, Djalma Jose [UNIFESP]
Taha, Murched Omar [UNIFESP]
author_role author
author2 de Oliveira, Geraldo Ferreira
Simoes, Ricardo Santos [UNIFESP]
Tikazawa, Eduardo Hiroshi
Monteiro, Hugo Pequeno [UNIFESP]
Fagundes, Djalma Jose [UNIFESP]
Taha, Murched Omar [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro de Oliveira, Teresinha Regina [UNIFESP]
de Oliveira, Geraldo Ferreira
Simoes, Ricardo Santos [UNIFESP]
Tikazawa, Eduardo Hiroshi
Monteiro, Hugo Pequeno [UNIFESP]
Fagundes, Djalma Jose [UNIFESP]
Taha, Murched Omar [UNIFESP]
dc.subject.por.fl_str_mv Ischemic Preconditioning
Pentoxifylline
Ischemia
Reperfusion Injury
Intestines
Rats
topic Ischemic Preconditioning
Pentoxifylline
Ischemia
Reperfusion Injury
Intestines
Rats
description Purpose: To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR). Methods: Thirty rats were assigned to 5 groups (N= 6): (CG): no clamping of the superior mesenteric artery (90 min.)
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-06-26T16:30:27Z
2020-06-26T16:30:27Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/s0102-865020170070000007
Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 7, p. 559-567, 2017.
10.1590/s0102-865020170070000007
S0102-86502017000700559.pdf
0102-8650
S0102-86502017000700559
https://repositorio.unifesp.br/handle/11600/53550
WOS:000407368300007
url http://dx.doi.org/10.1590/s0102-865020170070000007
https://repositorio.unifesp.br/handle/11600/53550
identifier_str_mv Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 7, p. 559-567, 2017.
10.1590/s0102-865020170070000007
S0102-86502017000700559.pdf
0102-8650
S0102-86502017000700559
WOS:000407368300007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 559-567
application/pdf
dc.coverage.none.fl_str_mv Sao Paulo
dc.publisher.none.fl_str_mv Acta Cirurgica Brasileira
publisher.none.fl_str_mv Acta Cirurgica Brasileira
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268312735973376

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