The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35617 http://dx.doi.org/10.1016/j.jep.2012.10.026 |
Resumo: | Ethnopharmacological relevance: 'Resin-of-canuaru' is a medicine utilized by caboclos living in the Amazon Region, Brazil. There is a mystery regarding its origin because the caboclos maintain that this substance is derived only from animal secretions (from a frog called canuaru), whereas the historic literature claims that 'resin-of-canuaru' is derived solely from a plant exudate (resin). Based on our ethnographic studies, we hypothesized that this substance is a combination of both. Because the past reports on this resiniferous material in the literature are based solely on observations, we aimed to present ethnographic, zoological and chemical data to try to elucidate the origin of the 'resin-of-canuaru'.Materials and methods: Ethnographic techniques and methods were applied, including participant observation, the use of field diaries and informal and unstructured interviews. the canuaru frog (Trachycephalus resinifictrix Goeldi, 1907) and 'resin-of-canuaru' were collected for taxonomic identification and chemical analysis, respectively. the resiniferous 'resin-of-canuaru' was extracted using MeOH and then analyzed by silica gel TLC and NMR.Results: Canuaru frogs live in tree cavities and secrete a large amount of substances during spawning, resulting in a resiniferous material. NMR analysis of the MeOH extract of this crude material showed peaks assigned to 3,4-secofriedel-4(23)-en-3-oic acid (putranjuvic acid) and its methyl ester derivative (methyl putranjivate) and to biogenetic precursor of these two compounds (a lactone derivative), which is formed by the oxidation of friedelin. Based on evidence that Protium species accumulate primarily tetracyclic/pentacyclic triterpenoids and that the co-occurrence of the compounds listed above is rarely described in plant species, we suggest that these compounds could be products of the biotransformation of friedelin by the frog.Conclusions: According to our data, the 'resin-of-canuaru' seems to have both animal and vegetal origins. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
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Rodrigues, Eliana [UNIFESP]Santos, Juliana de Faria Lima [UNIFESP]Souza, Sarah M.Lago, Joao Henrique Ghilardi [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:28:09Z2016-01-24T14:28:09Z2012-12-18Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 144, n. 3, p. 806-808, 2012.0378-8741http://repositorio.unifesp.br/handle/11600/35617http://dx.doi.org/10.1016/j.jep.2012.10.026WOS000313391300049.pdf10.1016/j.jep.2012.10.026WOS:000313391300049Ethnopharmacological relevance: 'Resin-of-canuaru' is a medicine utilized by caboclos living in the Amazon Region, Brazil. There is a mystery regarding its origin because the caboclos maintain that this substance is derived only from animal secretions (from a frog called canuaru), whereas the historic literature claims that 'resin-of-canuaru' is derived solely from a plant exudate (resin). Based on our ethnographic studies, we hypothesized that this substance is a combination of both. Because the past reports on this resiniferous material in the literature are based solely on observations, we aimed to present ethnographic, zoological and chemical data to try to elucidate the origin of the 'resin-of-canuaru'.Materials and methods: Ethnographic techniques and methods were applied, including participant observation, the use of field diaries and informal and unstructured interviews. the canuaru frog (Trachycephalus resinifictrix Goeldi, 1907) and 'resin-of-canuaru' were collected for taxonomic identification and chemical analysis, respectively. the resiniferous 'resin-of-canuaru' was extracted using MeOH and then analyzed by silica gel TLC and NMR.Results: Canuaru frogs live in tree cavities and secrete a large amount of substances during spawning, resulting in a resiniferous material. NMR analysis of the MeOH extract of this crude material showed peaks assigned to 3,4-secofriedel-4(23)-en-3-oic acid (putranjuvic acid) and its methyl ester derivative (methyl putranjivate) and to biogenetic precursor of these two compounds (a lactone derivative), which is formed by the oxidation of friedelin. Based on evidence that Protium species accumulate primarily tetracyclic/pentacyclic triterpenoids and that the co-occurrence of the compounds listed above is rarely described in plant species, we suggest that these compounds could be products of the biotransformation of friedelin by the frog.Conclusions: According to our data, the 'resin-of-canuaru' seems to have both animal and vegetal origins. (C) 2012 Elsevier Ireland Ltd. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)AFIPUniversidade Federal de São Paulo UNIFESP, Ctr Ethnobot & Ethnopharmacol Studies CEE, Inst Environm Sci Chem & Pharmaceut, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Ctr Ethnobot & Ethnopharmacol Studies CEE, Inst Environm Sci Chem & Pharmaceut, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, São Paulo, BrazilWeb of Science806-808engElsevier B.V.Journal of Ethnopharmacologyhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessEthnozoologyExudatesTriterpenoidPainField studyHistorical sourcesThe mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000313391300049.pdfapplication/pdf184858${dspace.ui.url}/bitstream/11600/35617/1/WOS000313391300049.pdfcda6e902b72f9c40b1084b841e0848c0MD51open accessTEXTWOS000313391300049.pdf.txtWOS000313391300049.pdf.txtExtracted texttext/plain19726${dspace.ui.url}/bitstream/11600/35617/2/WOS000313391300049.pdf.txtf5a78ed54cd3725c0cc9e96cf5c282dcMD52open access11600/356172021-09-30 15:48:17.405open accessoai:repositorio.unifesp.br:11600/35617Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-30T18:48:17Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil |
title |
The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil |
spellingShingle |
The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil Rodrigues, Eliana [UNIFESP] Ethnozoology Exudates Triterpenoid Pain Field study Historical sources |
title_short |
The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil |
title_full |
The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil |
title_fullStr |
The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil |
title_full_unstemmed |
The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil |
title_sort |
The mystery of the 'resin-of-canuaru': A medicine used by caboclos river-dwellers of the Amazon, Amazonas, Brazil |
author |
Rodrigues, Eliana [UNIFESP] |
author_facet |
Rodrigues, Eliana [UNIFESP] Santos, Juliana de Faria Lima [UNIFESP] Souza, Sarah M. Lago, Joao Henrique Ghilardi [UNIFESP] |
author_role |
author |
author2 |
Santos, Juliana de Faria Lima [UNIFESP] Souza, Sarah M. Lago, Joao Henrique Ghilardi [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Rodrigues, Eliana [UNIFESP] Santos, Juliana de Faria Lima [UNIFESP] Souza, Sarah M. Lago, Joao Henrique Ghilardi [UNIFESP] |
dc.subject.eng.fl_str_mv |
Ethnozoology Exudates Triterpenoid Pain Field study Historical sources |
topic |
Ethnozoology Exudates Triterpenoid Pain Field study Historical sources |
description |
Ethnopharmacological relevance: 'Resin-of-canuaru' is a medicine utilized by caboclos living in the Amazon Region, Brazil. There is a mystery regarding its origin because the caboclos maintain that this substance is derived only from animal secretions (from a frog called canuaru), whereas the historic literature claims that 'resin-of-canuaru' is derived solely from a plant exudate (resin). Based on our ethnographic studies, we hypothesized that this substance is a combination of both. Because the past reports on this resiniferous material in the literature are based solely on observations, we aimed to present ethnographic, zoological and chemical data to try to elucidate the origin of the 'resin-of-canuaru'.Materials and methods: Ethnographic techniques and methods were applied, including participant observation, the use of field diaries and informal and unstructured interviews. the canuaru frog (Trachycephalus resinifictrix Goeldi, 1907) and 'resin-of-canuaru' were collected for taxonomic identification and chemical analysis, respectively. the resiniferous 'resin-of-canuaru' was extracted using MeOH and then analyzed by silica gel TLC and NMR.Results: Canuaru frogs live in tree cavities and secrete a large amount of substances during spawning, resulting in a resiniferous material. NMR analysis of the MeOH extract of this crude material showed peaks assigned to 3,4-secofriedel-4(23)-en-3-oic acid (putranjuvic acid) and its methyl ester derivative (methyl putranjivate) and to biogenetic precursor of these two compounds (a lactone derivative), which is formed by the oxidation of friedelin. Based on evidence that Protium species accumulate primarily tetracyclic/pentacyclic triterpenoids and that the co-occurrence of the compounds listed above is rarely described in plant species, we suggest that these compounds could be products of the biotransformation of friedelin by the frog.Conclusions: According to our data, the 'resin-of-canuaru' seems to have both animal and vegetal origins. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-12-18 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:28:09Z |
dc.date.available.fl_str_mv |
2016-01-24T14:28:09Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 144, n. 3, p. 806-808, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35617 http://dx.doi.org/10.1016/j.jep.2012.10.026 |
dc.identifier.issn.none.fl_str_mv |
0378-8741 |
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WOS000313391300049.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.jep.2012.10.026 |
dc.identifier.wos.none.fl_str_mv |
WOS:000313391300049 |
identifier_str_mv |
Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 144, n. 3, p. 806-808, 2012. 0378-8741 WOS000313391300049.pdf 10.1016/j.jep.2012.10.026 WOS:000313391300049 |
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http://repositorio.unifesp.br/handle/11600/35617 http://dx.doi.org/10.1016/j.jep.2012.10.026 |
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eng |
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eng |
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Journal of Ethnopharmacology |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
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806-808 |
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Elsevier B.V. |
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Elsevier B.V. |
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