Gastroesophageal Reflux Causing Sleep Interruptions in Infants
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36114 http://dx.doi.org/10.1097/MPG.0b013e31827f02f2 |
Resumo: | Background and Aim: Little is known about the relation between gastroesophageal reflux (GER) episodes and sleep interruptions in infants. the aim of the study was to evaluate the relationship between GER and the incidence of sleep interruptions in infants.Methods: Study patients included 24 infants (younger than 1 year) referred for multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria were a previous fundoplication and studies lasting <20 hours. Tests were clinically indicated to investigate suspicion of GER-related apnea (17, 70.8%), stridor (6, 25%), noisy breathing (2, 8.3%), and cyanotic spells (1, 4.2%). Most patients presented with significant comorbidities (19, 79.2%).Results: the number of nonacid GER (NAGER) per hour was greater during sleep time than during daytime and awakening following sleep onset (median 0.27 vs 1.85 and 1.45, P < 0.01). A total of 1204 (range 7-86 per infant) arousals in 24 infants was detected, 165 (13.7%) that followed GER episodes, and 43 (3.6%) that preceded GER episodes. Seven patients presented with a positive symptom association probability for arousals; 5 were exclusively because of NAGER. A positive symptom association probability for awakenings was detected in 9 patients; 4 were because of NAGER, 4 were because of AGER, and 1 was because of both NAGER and GER. Patients with awakenings related to GER presented longer mean clearance time of AGER during sleep (165.5 vs 92.8 seconds, P = 0.03).Conclusions: GER was a frequent cause of interrupting sleep among our infant patients, and NAGER proved to be equally important as AGER for causing arousals and awakenings in infants. |
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Machado, Rodrigo [UNIFESP]Woodley, Frederick W.Skaggs, BethDi Lorenzo, CarloSplaingard, MarkMousa, HayatUniversidade Federal de São Paulo (UNIFESP)Nationwide Childrens Hosp2016-01-24T14:31:27Z2016-01-24T14:31:27Z2013-04-01Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 56, n. 4, p. 431-435, 2013.0277-2116http://repositorio.unifesp.br/handle/11600/36114http://dx.doi.org/10.1097/MPG.0b013e31827f02f210.1097/MPG.0b013e31827f02f2WOS:000316724400022Background and Aim: Little is known about the relation between gastroesophageal reflux (GER) episodes and sleep interruptions in infants. the aim of the study was to evaluate the relationship between GER and the incidence of sleep interruptions in infants.Methods: Study patients included 24 infants (younger than 1 year) referred for multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria were a previous fundoplication and studies lasting <20 hours. Tests were clinically indicated to investigate suspicion of GER-related apnea (17, 70.8%), stridor (6, 25%), noisy breathing (2, 8.3%), and cyanotic spells (1, 4.2%). Most patients presented with significant comorbidities (19, 79.2%).Results: the number of nonacid GER (NAGER) per hour was greater during sleep time than during daytime and awakening following sleep onset (median 0.27 vs 1.85 and 1.45, P < 0.01). A total of 1204 (range 7-86 per infant) arousals in 24 infants was detected, 165 (13.7%) that followed GER episodes, and 43 (3.6%) that preceded GER episodes. Seven patients presented with a positive symptom association probability for arousals; 5 were exclusively because of NAGER. A positive symptom association probability for awakenings was detected in 9 patients; 4 were because of NAGER, 4 were because of AGER, and 1 was because of both NAGER and GER. Patients with awakenings related to GER presented longer mean clearance time of AGER during sleep (165.5 vs 92.8 seconds, P = 0.03).Conclusions: GER was a frequent cause of interrupting sleep among our infant patients, and NAGER proved to be equally important as AGER for causing arousals and awakenings in infants.Fed Univ São Paulo UNIFESP, Dept Pediat, São Paulo, BrazilNationwide Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Columbus, OH 43205 USANationwide Childrens Hosp, Div Pulm Med, Sleep Lab, Columbus, OH 43205 USAFed Univ São Paulo UNIFESP, Dept Pediat, São Paulo, BrazilWeb of Science431-435engLippincott Williams & WilkinsJournal of Pediatric Gastroenterology and Nutritiongastroesophageal reflux diseaseimpedanceinfantsinterruptedsleep disordersGastroesophageal Reflux Causing Sleep Interruptions in Infantsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/361142021-09-28 21:26:30.998metadata only accessoai:repositorio.unifesp.br:11600/36114Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-29T00:26:30Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Gastroesophageal Reflux Causing Sleep Interruptions in Infants |
title |
Gastroesophageal Reflux Causing Sleep Interruptions in Infants |
spellingShingle |
Gastroesophageal Reflux Causing Sleep Interruptions in Infants Machado, Rodrigo [UNIFESP] gastroesophageal reflux disease impedance infants interrupted sleep disorders |
title_short |
Gastroesophageal Reflux Causing Sleep Interruptions in Infants |
title_full |
Gastroesophageal Reflux Causing Sleep Interruptions in Infants |
title_fullStr |
Gastroesophageal Reflux Causing Sleep Interruptions in Infants |
title_full_unstemmed |
Gastroesophageal Reflux Causing Sleep Interruptions in Infants |
title_sort |
Gastroesophageal Reflux Causing Sleep Interruptions in Infants |
author |
Machado, Rodrigo [UNIFESP] |
author_facet |
Machado, Rodrigo [UNIFESP] Woodley, Frederick W. Skaggs, Beth Di Lorenzo, Carlo Splaingard, Mark Mousa, Hayat |
author_role |
author |
author2 |
Woodley, Frederick W. Skaggs, Beth Di Lorenzo, Carlo Splaingard, Mark Mousa, Hayat |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Nationwide Childrens Hosp |
dc.contributor.author.fl_str_mv |
Machado, Rodrigo [UNIFESP] Woodley, Frederick W. Skaggs, Beth Di Lorenzo, Carlo Splaingard, Mark Mousa, Hayat |
dc.subject.eng.fl_str_mv |
gastroesophageal reflux disease impedance infants interrupted sleep disorders |
topic |
gastroesophageal reflux disease impedance infants interrupted sleep disorders |
description |
Background and Aim: Little is known about the relation between gastroesophageal reflux (GER) episodes and sleep interruptions in infants. the aim of the study was to evaluate the relationship between GER and the incidence of sleep interruptions in infants.Methods: Study patients included 24 infants (younger than 1 year) referred for multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria were a previous fundoplication and studies lasting <20 hours. Tests were clinically indicated to investigate suspicion of GER-related apnea (17, 70.8%), stridor (6, 25%), noisy breathing (2, 8.3%), and cyanotic spells (1, 4.2%). Most patients presented with significant comorbidities (19, 79.2%).Results: the number of nonacid GER (NAGER) per hour was greater during sleep time than during daytime and awakening following sleep onset (median 0.27 vs 1.85 and 1.45, P < 0.01). A total of 1204 (range 7-86 per infant) arousals in 24 infants was detected, 165 (13.7%) that followed GER episodes, and 43 (3.6%) that preceded GER episodes. Seven patients presented with a positive symptom association probability for arousals; 5 were exclusively because of NAGER. A positive symptom association probability for awakenings was detected in 9 patients; 4 were because of NAGER, 4 were because of AGER, and 1 was because of both NAGER and GER. Patients with awakenings related to GER presented longer mean clearance time of AGER during sleep (165.5 vs 92.8 seconds, P = 0.03).Conclusions: GER was a frequent cause of interrupting sleep among our infant patients, and NAGER proved to be equally important as AGER for causing arousals and awakenings in infants. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-04-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:27Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 56, n. 4, p. 431-435, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36114 http://dx.doi.org/10.1097/MPG.0b013e31827f02f2 |
dc.identifier.issn.none.fl_str_mv |
0277-2116 |
dc.identifier.doi.none.fl_str_mv |
10.1097/MPG.0b013e31827f02f2 |
dc.identifier.wos.none.fl_str_mv |
WOS:000316724400022 |
identifier_str_mv |
Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 56, n. 4, p. 431-435, 2013. 0277-2116 10.1097/MPG.0b013e31827f02f2 WOS:000316724400022 |
url |
http://repositorio.unifesp.br/handle/11600/36114 http://dx.doi.org/10.1097/MPG.0b013e31827f02f2 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal of Pediatric Gastroenterology and Nutrition |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
431-435 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764167366574080 |