Terapia de reposição hormonal no hipopituitarismo

Detalhes bibliográficos
Autor(a) principal: Abucham, Julio [UNIFESP]
Data de Publicação: 2003
Outros Autores: Vieira, Teresa C. Alfinito [UNIFESP], Barbosa, Erika Ribeiro [UNIFESP], Ribeiro, Rogério Silicani [UNIFESP], Martins, Manoel R. Alves [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27302003000400021
http://repositorio.unifesp.br/handle/11600/1781
Resumo: This article brings an updated review of hypopituitarism with emphasis in hormone replacement therapy. The physiological basis of hormone replacement therapy and practical aspects of treating hypopituitary patients were both taken into account to provide a rational strategy for treatment. The review is organized by individual pituitary hormone deficiency and covers epidemiology, etiology, clinical presentation, and diagnosis of hypopituitarism, as well as the most relevant hormone preparations currently available for treating each hormone deficiency. Practical guidelines to hormone dosing, routes of administration, side effects and clinical and laboratory monitoring during the entire lifespan are given for each individual hormone replacement therapy: growth hormone in GH-deficient children and adults, thyroid hormone in central hypothyroidism, glucocorticoid in central hypoadrenalism, vasopressin analogs in diabetes insipidus, sex hormones in man and women from puberty to senescence, and gonadotropins for treating infertility. In addition to the literature review, we took into account our own experience of more than two decades in investigating, diagnosing, and treating hypopituitary patients at the Universidade Federal de São Paulo (UNIFESP).
id UFSP_719264dc582b01fa450c23776d9181b0
oai_identifier_str oai:repositorio.unifesp.br/:11600/1781
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Terapia de reposição hormonal no hipopituitarismoHormone replacement therapy in hypopituitarismHypopituitarismGHGonadotropinsTSHACTHInfertilityDiabetes insipidusHormonal replacement therapyHipopituitarismoGHGonadotrofinasTSHACTHInfertilidadeDiabetes insipidusReposição hormonalThis article brings an updated review of hypopituitarism with emphasis in hormone replacement therapy. The physiological basis of hormone replacement therapy and practical aspects of treating hypopituitary patients were both taken into account to provide a rational strategy for treatment. The review is organized by individual pituitary hormone deficiency and covers epidemiology, etiology, clinical presentation, and diagnosis of hypopituitarism, as well as the most relevant hormone preparations currently available for treating each hormone deficiency. Practical guidelines to hormone dosing, routes of administration, side effects and clinical and laboratory monitoring during the entire lifespan are given for each individual hormone replacement therapy: growth hormone in GH-deficient children and adults, thyroid hormone in central hypothyroidism, glucocorticoid in central hypoadrenalism, vasopressin analogs in diabetes insipidus, sex hormones in man and women from puberty to senescence, and gonadotropins for treating infertility. In addition to the literature review, we took into account our own experience of more than two decades in investigating, diagnosing, and treating hypopituitary patients at the Universidade Federal de São Paulo (UNIFESP).Esse artigo traz uma revisão do hipopituitarismo com ênfase na terapia de reposição hormonal. O conhecimento das bases fisiológicas da terapia de reposição hormonal, assim como dos aspectos práticos do tratamento, constitui o suporte racional para tratar esses pacientes. Essa revisão foi organizada por deficiência hormonal e cada um desses tópicos inclui epidemiologia, etiologia, apresentação clínica, diagnóstico, preparações hormonais disponíveis para o tratamento de cada deficiência, dosagens, vias de administração, efeitos colaterais e monitorização clínico-laboratorial durante os diferentes períodos da vida para cada reposição hormonal: hormônio de crescimento na criança e no adulto, hormônios tiroideanos no hipotiroidismo central, glicocorticóides no hipoadrenalismo central, análogos de vasopressina no diabetes insípidus central, esteróides sexuais no homem e na mulher, da puberdade à senescência e gonadotrofinas no tratamento da infertilidade. As informações aqui contidas resultam de uma revisão crítica da literatura aliada à nossa experiência de mais de duas décadas no diagnóstico e tratamento do paciente hipopituitário na Unidade de Neuroendocrinologia da Universidade Federal de São Paulo (UNIFESP).Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Unidade de NeuroendocrinologiaUNIFESP, Depto. de Medicina Unidade de NeuroendocrinologiaSciELOSociedade Brasileira de Endocrinologia e MetabologiaUniversidade Federal de São Paulo (UNIFESP)Abucham, Julio [UNIFESP]Vieira, Teresa C. Alfinito [UNIFESP]Barbosa, Erika Ribeiro [UNIFESP]Ribeiro, Rogério Silicani [UNIFESP]Martins, Manoel R. Alves [UNIFESP]2015-06-14T13:30:04Z2015-06-14T13:30:04Z2003-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion492-508application/pdfhttp://dx.doi.org/10.1590/S0004-27302003000400021Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 47, n. 4, p. 492-508, 2003.10.1590/S0004-27302003000400021S0004-27302003000400021.pdf0004-2730S0004-27302003000400021http://repositorio.unifesp.br/handle/11600/1781porArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T04:11:29Zoai:repositorio.unifesp.br/:11600/1781Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T04:11:29Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Terapia de reposição hormonal no hipopituitarismo
Hormone replacement therapy in hypopituitarism
title Terapia de reposição hormonal no hipopituitarismo
spellingShingle Terapia de reposição hormonal no hipopituitarismo
Abucham, Julio [UNIFESP]
Hypopituitarism
GH
Gonadotropins
TSH
ACTH
Infertility
Diabetes insipidus
Hormonal replacement therapy
Hipopituitarismo
GH
Gonadotrofinas
TSH
ACTH
Infertilidade
Diabetes insipidus
Reposição hormonal
title_short Terapia de reposição hormonal no hipopituitarismo
title_full Terapia de reposição hormonal no hipopituitarismo
title_fullStr Terapia de reposição hormonal no hipopituitarismo
title_full_unstemmed Terapia de reposição hormonal no hipopituitarismo
title_sort Terapia de reposição hormonal no hipopituitarismo
author Abucham, Julio [UNIFESP]
author_facet Abucham, Julio [UNIFESP]
Vieira, Teresa C. Alfinito [UNIFESP]
Barbosa, Erika Ribeiro [UNIFESP]
Ribeiro, Rogério Silicani [UNIFESP]
Martins, Manoel R. Alves [UNIFESP]
author_role author
author2 Vieira, Teresa C. Alfinito [UNIFESP]
Barbosa, Erika Ribeiro [UNIFESP]
Ribeiro, Rogério Silicani [UNIFESP]
Martins, Manoel R. Alves [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Abucham, Julio [UNIFESP]
Vieira, Teresa C. Alfinito [UNIFESP]
Barbosa, Erika Ribeiro [UNIFESP]
Ribeiro, Rogério Silicani [UNIFESP]
Martins, Manoel R. Alves [UNIFESP]
dc.subject.por.fl_str_mv Hypopituitarism
GH
Gonadotropins
TSH
ACTH
Infertility
Diabetes insipidus
Hormonal replacement therapy
Hipopituitarismo
GH
Gonadotrofinas
TSH
ACTH
Infertilidade
Diabetes insipidus
Reposição hormonal
topic Hypopituitarism
GH
Gonadotropins
TSH
ACTH
Infertility
Diabetes insipidus
Hormonal replacement therapy
Hipopituitarismo
GH
Gonadotrofinas
TSH
ACTH
Infertilidade
Diabetes insipidus
Reposição hormonal
description This article brings an updated review of hypopituitarism with emphasis in hormone replacement therapy. The physiological basis of hormone replacement therapy and practical aspects of treating hypopituitary patients were both taken into account to provide a rational strategy for treatment. The review is organized by individual pituitary hormone deficiency and covers epidemiology, etiology, clinical presentation, and diagnosis of hypopituitarism, as well as the most relevant hormone preparations currently available for treating each hormone deficiency. Practical guidelines to hormone dosing, routes of administration, side effects and clinical and laboratory monitoring during the entire lifespan are given for each individual hormone replacement therapy: growth hormone in GH-deficient children and adults, thyroid hormone in central hypothyroidism, glucocorticoid in central hypoadrenalism, vasopressin analogs in diabetes insipidus, sex hormones in man and women from puberty to senescence, and gonadotropins for treating infertility. In addition to the literature review, we took into account our own experience of more than two decades in investigating, diagnosing, and treating hypopituitary patients at the Universidade Federal de São Paulo (UNIFESP).
publishDate 2003
dc.date.none.fl_str_mv 2003-08-01
2015-06-14T13:30:04Z
2015-06-14T13:30:04Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27302003000400021
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 47, n. 4, p. 492-508, 2003.
10.1590/S0004-27302003000400021
S0004-27302003000400021.pdf
0004-2730
S0004-27302003000400021
http://repositorio.unifesp.br/handle/11600/1781
url http://dx.doi.org/10.1590/S0004-27302003000400021
http://repositorio.unifesp.br/handle/11600/1781
identifier_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 47, n. 4, p. 492-508, 2003.
10.1590/S0004-27302003000400021
S0004-27302003000400021.pdf
0004-2730
S0004-27302003000400021
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 492-508
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268347971272704