Terapia de reposição hormonal no hipopituitarismo
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0004-27302003000400021 http://repositorio.unifesp.br/handle/11600/1781 |
Resumo: | This article brings an updated review of hypopituitarism with emphasis in hormone replacement therapy. The physiological basis of hormone replacement therapy and practical aspects of treating hypopituitary patients were both taken into account to provide a rational strategy for treatment. The review is organized by individual pituitary hormone deficiency and covers epidemiology, etiology, clinical presentation, and diagnosis of hypopituitarism, as well as the most relevant hormone preparations currently available for treating each hormone deficiency. Practical guidelines to hormone dosing, routes of administration, side effects and clinical and laboratory monitoring during the entire lifespan are given for each individual hormone replacement therapy: growth hormone in GH-deficient children and adults, thyroid hormone in central hypothyroidism, glucocorticoid in central hypoadrenalism, vasopressin analogs in diabetes insipidus, sex hormones in man and women from puberty to senescence, and gonadotropins for treating infertility. In addition to the literature review, we took into account our own experience of more than two decades in investigating, diagnosing, and treating hypopituitary patients at the Universidade Federal de São Paulo (UNIFESP). |
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Terapia de reposição hormonal no hipopituitarismoHormone replacement therapy in hypopituitarismHypopituitarismGHGonadotropinsTSHACTHInfertilityDiabetes insipidusHormonal replacement therapyHipopituitarismoGHGonadotrofinasTSHACTHInfertilidadeDiabetes insipidusReposição hormonalThis article brings an updated review of hypopituitarism with emphasis in hormone replacement therapy. The physiological basis of hormone replacement therapy and practical aspects of treating hypopituitary patients were both taken into account to provide a rational strategy for treatment. The review is organized by individual pituitary hormone deficiency and covers epidemiology, etiology, clinical presentation, and diagnosis of hypopituitarism, as well as the most relevant hormone preparations currently available for treating each hormone deficiency. Practical guidelines to hormone dosing, routes of administration, side effects and clinical and laboratory monitoring during the entire lifespan are given for each individual hormone replacement therapy: growth hormone in GH-deficient children and adults, thyroid hormone in central hypothyroidism, glucocorticoid in central hypoadrenalism, vasopressin analogs in diabetes insipidus, sex hormones in man and women from puberty to senescence, and gonadotropins for treating infertility. In addition to the literature review, we took into account our own experience of more than two decades in investigating, diagnosing, and treating hypopituitary patients at the Universidade Federal de São Paulo (UNIFESP).Esse artigo traz uma revisão do hipopituitarismo com ênfase na terapia de reposição hormonal. O conhecimento das bases fisiológicas da terapia de reposição hormonal, assim como dos aspectos práticos do tratamento, constitui o suporte racional para tratar esses pacientes. Essa revisão foi organizada por deficiência hormonal e cada um desses tópicos inclui epidemiologia, etiologia, apresentação clínica, diagnóstico, preparações hormonais disponíveis para o tratamento de cada deficiência, dosagens, vias de administração, efeitos colaterais e monitorização clínico-laboratorial durante os diferentes períodos da vida para cada reposição hormonal: hormônio de crescimento na criança e no adulto, hormônios tiroideanos no hipotiroidismo central, glicocorticóides no hipoadrenalismo central, análogos de vasopressina no diabetes insípidus central, esteróides sexuais no homem e na mulher, da puberdade à senescência e gonadotrofinas no tratamento da infertilidade. As informações aqui contidas resultam de uma revisão crítica da literatura aliada à nossa experiência de mais de duas décadas no diagnóstico e tratamento do paciente hipopituitário na Unidade de Neuroendocrinologia da Universidade Federal de São Paulo (UNIFESP).Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Unidade de NeuroendocrinologiaUNIFESP, Depto. de Medicina Unidade de NeuroendocrinologiaSciELOSociedade Brasileira de Endocrinologia e MetabologiaUniversidade Federal de São Paulo (UNIFESP)Abucham, Julio [UNIFESP]Vieira, Teresa C. Alfinito [UNIFESP]Barbosa, Erika Ribeiro [UNIFESP]Ribeiro, Rogério Silicani [UNIFESP]Martins, Manoel R. Alves [UNIFESP]2015-06-14T13:30:04Z2015-06-14T13:30:04Z2003-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion492-508application/pdfhttp://dx.doi.org/10.1590/S0004-27302003000400021Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 47, n. 4, p. 492-508, 2003.10.1590/S0004-27302003000400021S0004-27302003000400021.pdf0004-2730S0004-27302003000400021http://repositorio.unifesp.br/handle/11600/1781porArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T04:11:29Zoai:repositorio.unifesp.br/:11600/1781Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T04:11:29Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Terapia de reposição hormonal no hipopituitarismo Hormone replacement therapy in hypopituitarism |
title |
Terapia de reposição hormonal no hipopituitarismo |
spellingShingle |
Terapia de reposição hormonal no hipopituitarismo Abucham, Julio [UNIFESP] Hypopituitarism GH Gonadotropins TSH ACTH Infertility Diabetes insipidus Hormonal replacement therapy Hipopituitarismo GH Gonadotrofinas TSH ACTH Infertilidade Diabetes insipidus Reposição hormonal |
title_short |
Terapia de reposição hormonal no hipopituitarismo |
title_full |
Terapia de reposição hormonal no hipopituitarismo |
title_fullStr |
Terapia de reposição hormonal no hipopituitarismo |
title_full_unstemmed |
Terapia de reposição hormonal no hipopituitarismo |
title_sort |
Terapia de reposição hormonal no hipopituitarismo |
author |
Abucham, Julio [UNIFESP] |
author_facet |
Abucham, Julio [UNIFESP] Vieira, Teresa C. Alfinito [UNIFESP] Barbosa, Erika Ribeiro [UNIFESP] Ribeiro, Rogério Silicani [UNIFESP] Martins, Manoel R. Alves [UNIFESP] |
author_role |
author |
author2 |
Vieira, Teresa C. Alfinito [UNIFESP] Barbosa, Erika Ribeiro [UNIFESP] Ribeiro, Rogério Silicani [UNIFESP] Martins, Manoel R. Alves [UNIFESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Abucham, Julio [UNIFESP] Vieira, Teresa C. Alfinito [UNIFESP] Barbosa, Erika Ribeiro [UNIFESP] Ribeiro, Rogério Silicani [UNIFESP] Martins, Manoel R. Alves [UNIFESP] |
dc.subject.por.fl_str_mv |
Hypopituitarism GH Gonadotropins TSH ACTH Infertility Diabetes insipidus Hormonal replacement therapy Hipopituitarismo GH Gonadotrofinas TSH ACTH Infertilidade Diabetes insipidus Reposição hormonal |
topic |
Hypopituitarism GH Gonadotropins TSH ACTH Infertility Diabetes insipidus Hormonal replacement therapy Hipopituitarismo GH Gonadotrofinas TSH ACTH Infertilidade Diabetes insipidus Reposição hormonal |
description |
This article brings an updated review of hypopituitarism with emphasis in hormone replacement therapy. The physiological basis of hormone replacement therapy and practical aspects of treating hypopituitary patients were both taken into account to provide a rational strategy for treatment. The review is organized by individual pituitary hormone deficiency and covers epidemiology, etiology, clinical presentation, and diagnosis of hypopituitarism, as well as the most relevant hormone preparations currently available for treating each hormone deficiency. Practical guidelines to hormone dosing, routes of administration, side effects and clinical and laboratory monitoring during the entire lifespan are given for each individual hormone replacement therapy: growth hormone in GH-deficient children and adults, thyroid hormone in central hypothyroidism, glucocorticoid in central hypoadrenalism, vasopressin analogs in diabetes insipidus, sex hormones in man and women from puberty to senescence, and gonadotropins for treating infertility. In addition to the literature review, we took into account our own experience of more than two decades in investigating, diagnosing, and treating hypopituitary patients at the Universidade Federal de São Paulo (UNIFESP). |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-08-01 2015-06-14T13:30:04Z 2015-06-14T13:30:04Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-27302003000400021 Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 47, n. 4, p. 492-508, 2003. 10.1590/S0004-27302003000400021 S0004-27302003000400021.pdf 0004-2730 S0004-27302003000400021 http://repositorio.unifesp.br/handle/11600/1781 |
url |
http://dx.doi.org/10.1590/S0004-27302003000400021 http://repositorio.unifesp.br/handle/11600/1781 |
identifier_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 47, n. 4, p. 492-508, 2003. 10.1590/S0004-27302003000400021 S0004-27302003000400021.pdf 0004-2730 S0004-27302003000400021 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
492-508 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268347971272704 |