Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?

Detalhes bibliográficos
Autor(a) principal: Teixeira, Fábio Vieira
Data de Publicação: 2011
Outros Autores: Hossne, Rogério Saad, Kotze, Paulo Gustavo, Denadai, Rafael, Miszputen, Sender Jankiel [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000006gpc
Texto Completo: http://dx.doi.org/10.1590/S2237-93632011000400002
http://repositorio.unifesp.br/handle/11600/6786
Resumo: Ulcerative colitis treatment intends to induce remission, and its maintenance. Biological drugs, such as infliximab, have been indicated in moderate and severe cases of the disease, which are unresponsive to conventional medication. Randomized controlled trials proved the efficacy of biological treatment with high rates of sustained disease remission and mucosal healing. Recently, the concept of mucosal healing has been inversely associated with surgical treatment. Patients treated with infliximab have lower colectomy rates than those receiving conventional therapies. We suppose that earlier use of biological drugs in disease's course would lead to better clinical control and mucosal healing, with a consequent reduction in colectomy rates. To support this hypothesis, a literature review from January, 1996 to April, 2011 was performed.
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spelling Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?biological therapycolectomycolitis, ulcerativetreatment outcometerapia biológicacolectomiacolite ulcerativaresultado do tratamentoUlcerative colitis treatment intends to induce remission, and its maintenance. Biological drugs, such as infliximab, have been indicated in moderate and severe cases of the disease, which are unresponsive to conventional medication. Randomized controlled trials proved the efficacy of biological treatment with high rates of sustained disease remission and mucosal healing. Recently, the concept of mucosal healing has been inversely associated with surgical treatment. Patients treated with infliximab have lower colectomy rates than those receiving conventional therapies. We suppose that earlier use of biological drugs in disease's course would lead to better clinical control and mucosal healing, with a consequent reduction in colectomy rates. To support this hypothesis, a literature review from January, 1996 to April, 2011 was performed.O tratamento da colite ulcerativa tem como objetivo induzir a remissão, além da manutenção da remissão da doença. Agentes biológicos como o infliximabe têm sido indicados em casos moderados e graves da doença, os quais não respondem à medicação convencional. Ensaios clínicos randomizados comprovaram a eficácia do tratamento biológico com altas taxas de remissão da doença e cicatrização sustentada da mucosa. Recentemente, o conceito de cicatrização da mucosa tem sido inversamente associado com o tratamento cirúrgico. Pacientes tratados com infliximabe têm taxas mais baixas de colectomia se comparados com aqueles que receberam terapias convencionais. Supõe-se que quanto mais cedo for introduzida a terapia biológica no curso da doença, melhor seriam o controle clínico e a cicatrização da mucosa, com consequente redução nas taxas de colectomia. Para apoiar esta hipótese, foi realizada uma revisão da literatura entre janeiro de 1996 e abril de 2011.University of the State of São Paulo Botucatu Medical School Department of SurgeryAssociação Beneficente Hospital Universitário and Clínica GastrosaúdePontifícia Universidade Católica Department of SurgeryHospital Universitário Cajuru Colorectal UnitFederal University of São Paulo Department of GastroenterologyUNIFESP, Department of GastroenterologySciELOSociedade Brasileira de ColoproctologiaUniversity of the State of São Paulo Botucatu Medical School Department of SurgeryAssociação Beneficente Hospital Universitário and Clínica GastrosaúdePontifícia Universidade Católica Department of SurgeryHospital Universitário Cajuru Colorectal UnitUniversidade Federal de São Paulo (UNIFESP)Teixeira, Fábio VieiraHossne, Rogério SaadKotze, Paulo GustavoDenadai, RafaelMiszputen, Sender Jankiel [UNIFESP]2015-06-14T13:43:26Z2015-06-14T13:43:26Z2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion325-329application/pdfhttp://dx.doi.org/10.1590/S2237-93632011000400002Journal of Coloproctology (Rio de Janeiro). Sociedade Brasileira de Coloproctologia, v. 31, n. 4, p. 325-329, 2011.10.1590/S2237-93632011000400002S2237-93632011000400002.pdf2237-9363S2237-93632011000400002http://repositorio.unifesp.br/handle/11600/6786ark:/48912/0013000006gpcengJournal of Coloproctology (Rio de Janeiro)info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T03:42:39Zoai:repositorio.unifesp.br/:11600/6786Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:00:48.458567Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
title Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
spellingShingle Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
Teixeira, Fábio Vieira
biological therapy
colectomy
colitis, ulcerative
treatment outcome
terapia biológica
colectomia
colite ulcerativa
resultado do tratamento
title_short Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
title_full Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
title_fullStr Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
title_full_unstemmed Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
title_sort Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
author Teixeira, Fábio Vieira
author_facet Teixeira, Fábio Vieira
Hossne, Rogério Saad
Kotze, Paulo Gustavo
Denadai, Rafael
Miszputen, Sender Jankiel [UNIFESP]
author_role author
author2 Hossne, Rogério Saad
Kotze, Paulo Gustavo
Denadai, Rafael
Miszputen, Sender Jankiel [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv University of the State of São Paulo Botucatu Medical School Department of Surgery
Associação Beneficente Hospital Universitário and Clínica Gastrosaúde
Pontifícia Universidade Católica Department of Surgery
Hospital Universitário Cajuru Colorectal Unit
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Teixeira, Fábio Vieira
Hossne, Rogério Saad
Kotze, Paulo Gustavo
Denadai, Rafael
Miszputen, Sender Jankiel [UNIFESP]
dc.subject.por.fl_str_mv biological therapy
colectomy
colitis, ulcerative
treatment outcome
terapia biológica
colectomia
colite ulcerativa
resultado do tratamento
topic biological therapy
colectomy
colitis, ulcerative
treatment outcome
terapia biológica
colectomia
colite ulcerativa
resultado do tratamento
description Ulcerative colitis treatment intends to induce remission, and its maintenance. Biological drugs, such as infliximab, have been indicated in moderate and severe cases of the disease, which are unresponsive to conventional medication. Randomized controlled trials proved the efficacy of biological treatment with high rates of sustained disease remission and mucosal healing. Recently, the concept of mucosal healing has been inversely associated with surgical treatment. Patients treated with infliximab have lower colectomy rates than those receiving conventional therapies. We suppose that earlier use of biological drugs in disease's course would lead to better clinical control and mucosal healing, with a consequent reduction in colectomy rates. To support this hypothesis, a literature review from January, 1996 to April, 2011 was performed.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
2015-06-14T13:43:26Z
2015-06-14T13:43:26Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S2237-93632011000400002
Journal of Coloproctology (Rio de Janeiro). Sociedade Brasileira de Coloproctologia, v. 31, n. 4, p. 325-329, 2011.
10.1590/S2237-93632011000400002
S2237-93632011000400002.pdf
2237-9363
S2237-93632011000400002
http://repositorio.unifesp.br/handle/11600/6786
dc.identifier.dark.fl_str_mv ark:/48912/0013000006gpc
url http://dx.doi.org/10.1590/S2237-93632011000400002
http://repositorio.unifesp.br/handle/11600/6786
identifier_str_mv Journal of Coloproctology (Rio de Janeiro). Sociedade Brasileira de Coloproctologia, v. 31, n. 4, p. 325-329, 2011.
10.1590/S2237-93632011000400002
S2237-93632011000400002.pdf
2237-9363
S2237-93632011000400002
ark:/48912/0013000006gpc
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Coloproctology (Rio de Janeiro)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 325-329
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1818602413674725376

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