Incidence of heart failure in infarcted rats that die spontaneously
Autor(a) principal: | |
---|---|
Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X2006001000008 http://repositorio.unifesp.br/handle/11600/3287 |
Resumo: | The present study reports for the first time the incidence of congestive heart failure (CHF) in previously infarcted rats that died spontaneously. Previously, pulmonary (PWC) and hepatic (HWC) water contents were determined in normal rats: 14 control animals were evaluated immediately after sacrifice, 8 placed in a refrigerator for 24 h, and 10 left at room temperature for 24 h. In the infarcted group, 9 rats died before (acute) and 28 died 48 h after (chronic) myocardial infarction. Thirteen chronic animals were submitted only to autopsy (N = 13), whereas PWC and HWC were also determined in the others (N = 15). Seven rats survived 48 h and died during anesthesia. Notably, PWC differed in normal rats: ambient (75.7 ± 1.3%) < control (77.5 ± 0.7%) < refrigerator (79.1 ± 1.4%) and there were no differences with respect to HWC. No clinical signs of CHF (dyspnea, lethargy or foot edema) were observed in infarcted rats before death. PWC was elevated in all chronic and anesthetized rats. HWC was increased in 48% of chronic and in all anesthetized rats. Our data showed that PWC needs to be evaluated before 24 h post mortem and that CHF is the rule in chronic infarcted rats suffering natural death. The congestive syndrome cannot be diagnosed correctly in rats by clinical signs alone, as previously proposed. |
id |
UFSP_7237ac65e3e7d8eed9de44d859854ba8 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/3287 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Incidence of heart failure in infarcted rats that die spontaneouslyHeart failureMyocardial infarctionRatsPulmonary congestionHepatic congestionThe present study reports for the first time the incidence of congestive heart failure (CHF) in previously infarcted rats that died spontaneously. Previously, pulmonary (PWC) and hepatic (HWC) water contents were determined in normal rats: 14 control animals were evaluated immediately after sacrifice, 8 placed in a refrigerator for 24 h, and 10 left at room temperature for 24 h. In the infarcted group, 9 rats died before (acute) and 28 died 48 h after (chronic) myocardial infarction. Thirteen chronic animals were submitted only to autopsy (N = 13), whereas PWC and HWC were also determined in the others (N = 15). Seven rats survived 48 h and died during anesthesia. Notably, PWC differed in normal rats: ambient (75.7 ± 1.3%) < control (77.5 ± 0.7%) < refrigerator (79.1 ± 1.4%) and there were no differences with respect to HWC. No clinical signs of CHF (dyspnea, lethargy or foot edema) were observed in infarcted rats before death. PWC was elevated in all chronic and anesthetized rats. HWC was increased in 48% of chronic and in all anesthetized rats. Our data showed that PWC needs to be evaluated before 24 h post mortem and that CHF is the rule in chronic infarcted rats suffering natural death. The congestive syndrome cannot be diagnosed correctly in rats by clinical signs alone, as previously proposed.Universidade Federal de São Paulo (UNIFESP) Divisão de Fisiologia CardiovascularUniversidade Federal de São Paulo (UNIFESP) Divisão de PatologiaUNIFESP, Divisão de Fisiologia CardiovascularUNIFESP, Divisão de PatologiaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Flumignan, Ronald Luiz Gomes [UNIFESP]Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]Saraiva, Roberto Magalhães [UNIFESP]Portes, Leslie Andrews [UNIFESP]Antonio, Ednei Luiz [UNIFESP]Ishigai, Marcia Marcelino de Souza [UNIFESP]Tucci, Paulo José Ferreira [UNIFESP]2015-06-14T13:36:28Z2015-06-14T13:36:28Z2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1323-1328application/pdfhttp://dx.doi.org/10.1590/S0100-879X2006001000008Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1323-1328, 2006.10.1590/S0100-879X2006001000008S0100-879X2006001000008.pdf0100-879XS0100-879X2006001000008http://repositorio.unifesp.br/handle/11600/3287WOS:000242173300008engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T23:07:11Zoai:repositorio.unifesp.br/:11600/3287Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T23:07:11Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Incidence of heart failure in infarcted rats that die spontaneously |
title |
Incidence of heart failure in infarcted rats that die spontaneously |
spellingShingle |
Incidence of heart failure in infarcted rats that die spontaneously Flumignan, Ronald Luiz Gomes [UNIFESP] Heart failure Myocardial infarction Rats Pulmonary congestion Hepatic congestion |
title_short |
Incidence of heart failure in infarcted rats that die spontaneously |
title_full |
Incidence of heart failure in infarcted rats that die spontaneously |
title_fullStr |
Incidence of heart failure in infarcted rats that die spontaneously |
title_full_unstemmed |
Incidence of heart failure in infarcted rats that die spontaneously |
title_sort |
Incidence of heart failure in infarcted rats that die spontaneously |
author |
Flumignan, Ronald Luiz Gomes [UNIFESP] |
author_facet |
Flumignan, Ronald Luiz Gomes [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Saraiva, Roberto Magalhães [UNIFESP] Portes, Leslie Andrews [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Ishigai, Marcia Marcelino de Souza [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
author_role |
author |
author2 |
Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Saraiva, Roberto Magalhães [UNIFESP] Portes, Leslie Andrews [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Ishigai, Marcia Marcelino de Souza [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Flumignan, Ronald Luiz Gomes [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Saraiva, Roberto Magalhães [UNIFESP] Portes, Leslie Andrews [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Ishigai, Marcia Marcelino de Souza [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
dc.subject.por.fl_str_mv |
Heart failure Myocardial infarction Rats Pulmonary congestion Hepatic congestion |
topic |
Heart failure Myocardial infarction Rats Pulmonary congestion Hepatic congestion |
description |
The present study reports for the first time the incidence of congestive heart failure (CHF) in previously infarcted rats that died spontaneously. Previously, pulmonary (PWC) and hepatic (HWC) water contents were determined in normal rats: 14 control animals were evaluated immediately after sacrifice, 8 placed in a refrigerator for 24 h, and 10 left at room temperature for 24 h. In the infarcted group, 9 rats died before (acute) and 28 died 48 h after (chronic) myocardial infarction. Thirteen chronic animals were submitted only to autopsy (N = 13), whereas PWC and HWC were also determined in the others (N = 15). Seven rats survived 48 h and died during anesthesia. Notably, PWC differed in normal rats: ambient (75.7 ± 1.3%) < control (77.5 ± 0.7%) < refrigerator (79.1 ± 1.4%) and there were no differences with respect to HWC. No clinical signs of CHF (dyspnea, lethargy or foot edema) were observed in infarcted rats before death. PWC was elevated in all chronic and anesthetized rats. HWC was increased in 48% of chronic and in all anesthetized rats. Our data showed that PWC needs to be evaluated before 24 h post mortem and that CHF is the rule in chronic infarcted rats suffering natural death. The congestive syndrome cannot be diagnosed correctly in rats by clinical signs alone, as previously proposed. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10-01 2015-06-14T13:36:28Z 2015-06-14T13:36:28Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2006001000008 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1323-1328, 2006. 10.1590/S0100-879X2006001000008 S0100-879X2006001000008.pdf 0100-879X S0100-879X2006001000008 http://repositorio.unifesp.br/handle/11600/3287 WOS:000242173300008 |
url |
http://dx.doi.org/10.1590/S0100-879X2006001000008 http://repositorio.unifesp.br/handle/11600/3287 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1323-1328, 2006. 10.1590/S0100-879X2006001000008 S0100-879X2006001000008.pdf 0100-879X S0100-879X2006001000008 WOS:000242173300008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1323-1328 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268317628628992 |