Incidence of heart failure in infarcted rats that die spontaneously

Detalhes bibliográficos
Autor(a) principal: Flumignan, Ronald Luiz Gomes [UNIFESP]
Data de Publicação: 2006
Outros Autores: Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP], Saraiva, Roberto Magalhães [UNIFESP], Portes, Leslie Andrews [UNIFESP], Antonio, Ednei Luiz [UNIFESP], Ishigai, Marcia Marcelino de Souza [UNIFESP], Tucci, Paulo José Ferreira [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2006001000008
http://repositorio.unifesp.br/handle/11600/3287
Resumo: The present study reports for the first time the incidence of congestive heart failure (CHF) in previously infarcted rats that died spontaneously. Previously, pulmonary (PWC) and hepatic (HWC) water contents were determined in normal rats: 14 control animals were evaluated immediately after sacrifice, 8 placed in a refrigerator for 24 h, and 10 left at room temperature for 24 h. In the infarcted group, 9 rats died before (acute) and 28 died 48 h after (chronic) myocardial infarction. Thirteen chronic animals were submitted only to autopsy (N = 13), whereas PWC and HWC were also determined in the others (N = 15). Seven rats survived 48 h and died during anesthesia. Notably, PWC differed in normal rats: ambient (75.7 ± 1.3%) < control (77.5 ± 0.7%) < refrigerator (79.1 ± 1.4%) and there were no differences with respect to HWC. No clinical signs of CHF (dyspnea, lethargy or foot edema) were observed in infarcted rats before death. PWC was elevated in all chronic and anesthetized rats. HWC was increased in 48% of chronic and in all anesthetized rats. Our data showed that PWC needs to be evaluated before 24 h post mortem and that CHF is the rule in chronic infarcted rats suffering natural death. The congestive syndrome cannot be diagnosed correctly in rats by clinical signs alone, as previously proposed.
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spelling Incidence of heart failure in infarcted rats that die spontaneouslyHeart failureMyocardial infarctionRatsPulmonary congestionHepatic congestionThe present study reports for the first time the incidence of congestive heart failure (CHF) in previously infarcted rats that died spontaneously. Previously, pulmonary (PWC) and hepatic (HWC) water contents were determined in normal rats: 14 control animals were evaluated immediately after sacrifice, 8 placed in a refrigerator for 24 h, and 10 left at room temperature for 24 h. In the infarcted group, 9 rats died before (acute) and 28 died 48 h after (chronic) myocardial infarction. Thirteen chronic animals were submitted only to autopsy (N = 13), whereas PWC and HWC were also determined in the others (N = 15). Seven rats survived 48 h and died during anesthesia. Notably, PWC differed in normal rats: ambient (75.7 ± 1.3%) < control (77.5 ± 0.7%) < refrigerator (79.1 ± 1.4%) and there were no differences with respect to HWC. No clinical signs of CHF (dyspnea, lethargy or foot edema) were observed in infarcted rats before death. PWC was elevated in all chronic and anesthetized rats. HWC was increased in 48% of chronic and in all anesthetized rats. Our data showed that PWC needs to be evaluated before 24 h post mortem and that CHF is the rule in chronic infarcted rats suffering natural death. The congestive syndrome cannot be diagnosed correctly in rats by clinical signs alone, as previously proposed.Universidade Federal de São Paulo (UNIFESP) Divisão de Fisiologia CardiovascularUniversidade Federal de São Paulo (UNIFESP) Divisão de PatologiaUNIFESP, Divisão de Fisiologia CardiovascularUNIFESP, Divisão de PatologiaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Flumignan, Ronald Luiz Gomes [UNIFESP]Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]Saraiva, Roberto Magalhães [UNIFESP]Portes, Leslie Andrews [UNIFESP]Antonio, Ednei Luiz [UNIFESP]Ishigai, Marcia Marcelino de Souza [UNIFESP]Tucci, Paulo José Ferreira [UNIFESP]2015-06-14T13:36:28Z2015-06-14T13:36:28Z2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1323-1328application/pdfhttp://dx.doi.org/10.1590/S0100-879X2006001000008Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1323-1328, 2006.10.1590/S0100-879X2006001000008S0100-879X2006001000008.pdf0100-879XS0100-879X2006001000008http://repositorio.unifesp.br/handle/11600/3287WOS:000242173300008engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T23:07:11Zoai:repositorio.unifesp.br/:11600/3287Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T23:07:11Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Incidence of heart failure in infarcted rats that die spontaneously
title Incidence of heart failure in infarcted rats that die spontaneously
spellingShingle Incidence of heart failure in infarcted rats that die spontaneously
Flumignan, Ronald Luiz Gomes [UNIFESP]
Heart failure
Myocardial infarction
Rats
Pulmonary congestion
Hepatic congestion
title_short Incidence of heart failure in infarcted rats that die spontaneously
title_full Incidence of heart failure in infarcted rats that die spontaneously
title_fullStr Incidence of heart failure in infarcted rats that die spontaneously
title_full_unstemmed Incidence of heart failure in infarcted rats that die spontaneously
title_sort Incidence of heart failure in infarcted rats that die spontaneously
author Flumignan, Ronald Luiz Gomes [UNIFESP]
author_facet Flumignan, Ronald Luiz Gomes [UNIFESP]
Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]
Saraiva, Roberto Magalhães [UNIFESP]
Portes, Leslie Andrews [UNIFESP]
Antonio, Ednei Luiz [UNIFESP]
Ishigai, Marcia Marcelino de Souza [UNIFESP]
Tucci, Paulo José Ferreira [UNIFESP]
author_role author
author2 Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]
Saraiva, Roberto Magalhães [UNIFESP]
Portes, Leslie Andrews [UNIFESP]
Antonio, Ednei Luiz [UNIFESP]
Ishigai, Marcia Marcelino de Souza [UNIFESP]
Tucci, Paulo José Ferreira [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Flumignan, Ronald Luiz Gomes [UNIFESP]
Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]
Saraiva, Roberto Magalhães [UNIFESP]
Portes, Leslie Andrews [UNIFESP]
Antonio, Ednei Luiz [UNIFESP]
Ishigai, Marcia Marcelino de Souza [UNIFESP]
Tucci, Paulo José Ferreira [UNIFESP]
dc.subject.por.fl_str_mv Heart failure
Myocardial infarction
Rats
Pulmonary congestion
Hepatic congestion
topic Heart failure
Myocardial infarction
Rats
Pulmonary congestion
Hepatic congestion
description The present study reports for the first time the incidence of congestive heart failure (CHF) in previously infarcted rats that died spontaneously. Previously, pulmonary (PWC) and hepatic (HWC) water contents were determined in normal rats: 14 control animals were evaluated immediately after sacrifice, 8 placed in a refrigerator for 24 h, and 10 left at room temperature for 24 h. In the infarcted group, 9 rats died before (acute) and 28 died 48 h after (chronic) myocardial infarction. Thirteen chronic animals were submitted only to autopsy (N = 13), whereas PWC and HWC were also determined in the others (N = 15). Seven rats survived 48 h and died during anesthesia. Notably, PWC differed in normal rats: ambient (75.7 ± 1.3%) < control (77.5 ± 0.7%) < refrigerator (79.1 ± 1.4%) and there were no differences with respect to HWC. No clinical signs of CHF (dyspnea, lethargy or foot edema) were observed in infarcted rats before death. PWC was elevated in all chronic and anesthetized rats. HWC was increased in 48% of chronic and in all anesthetized rats. Our data showed that PWC needs to be evaluated before 24 h post mortem and that CHF is the rule in chronic infarcted rats suffering natural death. The congestive syndrome cannot be diagnosed correctly in rats by clinical signs alone, as previously proposed.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
2015-06-14T13:36:28Z
2015-06-14T13:36:28Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2006001000008
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1323-1328, 2006.
10.1590/S0100-879X2006001000008
S0100-879X2006001000008.pdf
0100-879X
S0100-879X2006001000008
http://repositorio.unifesp.br/handle/11600/3287
WOS:000242173300008
url http://dx.doi.org/10.1590/S0100-879X2006001000008
http://repositorio.unifesp.br/handle/11600/3287
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1323-1328, 2006.
10.1590/S0100-879X2006001000008
S0100-879X2006001000008.pdf
0100-879X
S0100-879X2006001000008
WOS:000242173300008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1323-1328
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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