Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/9790 |
Resumo: | BACKGROUND: Photodynamic rejuvenation is the term used to the treatment of actinic keratosis and photodamage with photodynamic therapy. OBJECTIVE: Evaluate the efficacy of photodynamic therapy with aminolevulinic acid and intense pulsed light in the treatment of actinic keratosis and photodamage. METHODS: Fourty three patients mean age 71,3 years, were randomized in three groups: Control (IPL 18J); Treatment I (ALA+ IPL 16J); and Treatment II ( ALA+ IPL 18J) and evaluated clinically an photographically by two observers in Pre, 48hs, 8 weeks and 12 weeks Post-Treatment using Griffth’s Photonumeric Scale. Five actinic keratosis were marked as target in Pre-Treatment and biopsies Pre and Post-Treatment were done in one lesion to evaluate atypias and loss of cellular polarity. RESULTS: Non parametric tests showed marked improvement in mottled pigmentation, texture fine wrinkles in Groups Treatment I and II. In Control Group improvement only in mottled pigmentation. Actinic Keratosis clearance in Groups Treatment I and II were 51,2% and 68,4% respectively, whereas in Group Control it was 5%. In relation to Control Group, Groups Treatment I and II showed significant reduction of atypias and improvement in loss of cellular polarity. CONCLUSIONS: Photodynamic therapy with aminolevulinic acid and intense pulsed light is effective in the treatment of photodamage and actinic keratosis. The resolution of actinic keratosis was better with higher levels of energy. |
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Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facialIntense pulsed light and aminolevulinic acid in the treatment of photodamage and actinic kearatosisActinic keratosisAdultsAminolevulinic acid/therapeutic usePhotochemotherapySkin agingAdultoCeratose actínicaÁcido aminolevulínico/uso terapêuticoFotoenvelhecimento da peleFotoquimioterapiaBACKGROUND: Photodynamic rejuvenation is the term used to the treatment of actinic keratosis and photodamage with photodynamic therapy. OBJECTIVE: Evaluate the efficacy of photodynamic therapy with aminolevulinic acid and intense pulsed light in the treatment of actinic keratosis and photodamage. METHODS: Fourty three patients mean age 71,3 years, were randomized in three groups: Control (IPL 18J); Treatment I (ALA+ IPL 16J); and Treatment II ( ALA+ IPL 18J) and evaluated clinically an photographically by two observers in Pre, 48hs, 8 weeks and 12 weeks Post-Treatment using Griffth’s Photonumeric Scale. Five actinic keratosis were marked as target in Pre-Treatment and biopsies Pre and Post-Treatment were done in one lesion to evaluate atypias and loss of cellular polarity. RESULTS: Non parametric tests showed marked improvement in mottled pigmentation, texture fine wrinkles in Groups Treatment I and II. In Control Group improvement only in mottled pigmentation. Actinic Keratosis clearance in Groups Treatment I and II were 51,2% and 68,4% respectively, whereas in Group Control it was 5%. In relation to Control Group, Groups Treatment I and II showed significant reduction of atypias and improvement in loss of cellular polarity. CONCLUSIONS: Photodynamic therapy with aminolevulinic acid and intense pulsed light is effective in the treatment of photodamage and actinic keratosis. The resolution of actinic keratosis was better with higher levels of energy.INTRODUÇÃO: Rejuvenescimento fotodinâmico refere-se ao tratamento do fotoenvelhecimento e das queratoses actínicas. OBJETIVO: Avaliar a eficácia da terapia fotodinâmica com ácido aminolevulínico a 20% (ALA) ¾ tópico e luz intensa pulsada no tratamento das queratoses actínicas e do fotoenvelhecimento facial. MÉTODOS: Quarenta e três pacientes com idade média 71,3 anos, fototipos de pele I e IV divididos em: Controle (aplicação LIP/18J); Tratamento-I (ALA incubado por duas horas; ativado por duas passagens de LIP/16J); Tratamento-II (ALA; duas passagens de LIP/18J), foram avaliados por dois observadores, clínica e fotograficamente, no Pré, 48 horas, 8 e 12 semanas após, pela escala de Griffiths. Cinco queratoses actínicas foram marcadas como alvo para contagem no Pós- Tratamento, sendo uma submetida à biopsia antes e depois do tratamento, para avaliação anatomopatológica de atipias e perda de polaridade. RESULTADOS: Testes não-paramétricos mostraram melhora significativa (rugas finas, alterações texturais, pigmentação irregular) nos Grupos-Tratamento-I/II. No Grupo Controle, significância apenas para alterações pigmentares. Queratoses actínicas tiveram redução maior nos Grupos II (68, 4%) e I (51,2%) em relação ao Controle (5%). Houve redução significativa da gravidade das atipias e perda de polaridade nos Grupos-TratamentoI/II em relação ao controle. CONCLUSÃO: A terapia fotodinâmica, com ácido 5aminolevulínico e luz intensa pulsada, mostrou-se efetiva no tratamento do fotoenvelhecimento e das queratoses actínicas faciais. O tratamento das queratoses actínicas foi mais efetivo com uso de maior energia.TEDEBV UNIFESP: Teses e dissertaçõesUniversidade Federal de São Paulo (UNIFESP)Santos, Ivan Dunshee de Abranches Oliveira [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Haddad, Alessandra [UNIFESP]2015-07-22T20:50:24Z2015-07-22T20:50:24Z2010-04-28info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion179 f.application/pdfHADDAD, Alessandra. Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial. 2010. 179 f. Tese (Doutorado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, 2010.Publico-9790.pdfhttp://repositorio.unifesp.br/handle/11600/9790porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T16:10:28Zoai:repositorio.unifesp.br/:11600/9790Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T16:10:28Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial Intense pulsed light and aminolevulinic acid in the treatment of photodamage and actinic kearatosis |
title |
Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial |
spellingShingle |
Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial Haddad, Alessandra [UNIFESP] Actinic keratosis Adults Aminolevulinic acid/therapeutic use Photochemotherapy Skin aging Adulto Ceratose actínica Ácido aminolevulínico/uso terapêutico Fotoenvelhecimento da pele Fotoquimioterapia |
title_short |
Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial |
title_full |
Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial |
title_fullStr |
Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial |
title_full_unstemmed |
Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial |
title_sort |
Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial |
author |
Haddad, Alessandra [UNIFESP] |
author_facet |
Haddad, Alessandra [UNIFESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Santos, Ivan Dunshee de Abranches Oliveira [UNIFESP] Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Haddad, Alessandra [UNIFESP] |
dc.subject.por.fl_str_mv |
Actinic keratosis Adults Aminolevulinic acid/therapeutic use Photochemotherapy Skin aging Adulto Ceratose actínica Ácido aminolevulínico/uso terapêutico Fotoenvelhecimento da pele Fotoquimioterapia |
topic |
Actinic keratosis Adults Aminolevulinic acid/therapeutic use Photochemotherapy Skin aging Adulto Ceratose actínica Ácido aminolevulínico/uso terapêutico Fotoenvelhecimento da pele Fotoquimioterapia |
description |
BACKGROUND: Photodynamic rejuvenation is the term used to the treatment of actinic keratosis and photodamage with photodynamic therapy. OBJECTIVE: Evaluate the efficacy of photodynamic therapy with aminolevulinic acid and intense pulsed light in the treatment of actinic keratosis and photodamage. METHODS: Fourty three patients mean age 71,3 years, were randomized in three groups: Control (IPL 18J); Treatment I (ALA+ IPL 16J); and Treatment II ( ALA+ IPL 18J) and evaluated clinically an photographically by two observers in Pre, 48hs, 8 weeks and 12 weeks Post-Treatment using Griffth’s Photonumeric Scale. Five actinic keratosis were marked as target in Pre-Treatment and biopsies Pre and Post-Treatment were done in one lesion to evaluate atypias and loss of cellular polarity. RESULTS: Non parametric tests showed marked improvement in mottled pigmentation, texture fine wrinkles in Groups Treatment I and II. In Control Group improvement only in mottled pigmentation. Actinic Keratosis clearance in Groups Treatment I and II were 51,2% and 68,4% respectively, whereas in Group Control it was 5%. In relation to Control Group, Groups Treatment I and II showed significant reduction of atypias and improvement in loss of cellular polarity. CONCLUSIONS: Photodynamic therapy with aminolevulinic acid and intense pulsed light is effective in the treatment of photodamage and actinic keratosis. The resolution of actinic keratosis was better with higher levels of energy. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-04-28 2015-07-22T20:50:24Z 2015-07-22T20:50:24Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
HADDAD, Alessandra. Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial. 2010. 179 f. Tese (Doutorado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, 2010. Publico-9790.pdf http://repositorio.unifesp.br/handle/11600/9790 |
identifier_str_mv |
HADDAD, Alessandra. Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial. 2010. 179 f. Tese (Doutorado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, 2010. Publico-9790.pdf |
url |
http://repositorio.unifesp.br/handle/11600/9790 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
179 f. application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
publisher.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268426246422528 |