Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer

Detalhes bibliográficos
Autor(a) principal: Badiglian Filho, Levon [UNIFESP]
Data de Publicação: 2009
Outros Autores: Oshima, Celina Tizuko Fujiyama [UNIFESP], Lima, Flavio de Oliveira [UNIFESP], Costa, Henrique de Oliveira [UNIFESP], Damiao, Roberio de Sousa [UNIFESP], Gomes, Thiago Simao [UNIFESP], Goncalves, Wagner Jose [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.3892/or_00000223
http://repositorio.unifesp.br/handle/11600/31273
Resumo: The Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer.
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spelling Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancerbeta-cateninWnt5aWntFrizzledovarian cancerThe Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer.Universidade Federal de São Paulo, Dept Gynecol, Discipline Gynecol Oncol, BR-01424000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-01424000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Gynecol, Discipline Gynecol Oncol, BR-01424000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-01424000 São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 06/51401-1Spandidos Publ LtdUniversidade Federal de São Paulo (UNIFESP)Badiglian Filho, Levon [UNIFESP]Oshima, Celina Tizuko Fujiyama [UNIFESP]Lima, Flavio de Oliveira [UNIFESP]Costa, Henrique de Oliveira [UNIFESP]Damiao, Roberio de Sousa [UNIFESP]Gomes, Thiago Simao [UNIFESP]Goncalves, Wagner Jose [UNIFESP]2016-01-24T13:52:13Z2016-01-24T13:52:13Z2009-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion313-320http://dx.doi.org/10.3892/or_00000223Oncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 313-320, 2009.10.3892/or_000002231021-335Xhttp://repositorio.unifesp.br/handle/11600/31273WOS:000262679300006engOncology Reportsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T11:52:13Zoai:repositorio.unifesp.br/:11600/31273Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T11:52:13Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
title Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
spellingShingle Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
Badiglian Filho, Levon [UNIFESP]
beta-catenin
Wnt5a
Wnt
Frizzled
ovarian cancer
title_short Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
title_full Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
title_fullStr Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
title_full_unstemmed Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
title_sort Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
author Badiglian Filho, Levon [UNIFESP]
author_facet Badiglian Filho, Levon [UNIFESP]
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Lima, Flavio de Oliveira [UNIFESP]
Costa, Henrique de Oliveira [UNIFESP]
Damiao, Roberio de Sousa [UNIFESP]
Gomes, Thiago Simao [UNIFESP]
Goncalves, Wagner Jose [UNIFESP]
author_role author
author2 Oshima, Celina Tizuko Fujiyama [UNIFESP]
Lima, Flavio de Oliveira [UNIFESP]
Costa, Henrique de Oliveira [UNIFESP]
Damiao, Roberio de Sousa [UNIFESP]
Gomes, Thiago Simao [UNIFESP]
Goncalves, Wagner Jose [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Badiglian Filho, Levon [UNIFESP]
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Lima, Flavio de Oliveira [UNIFESP]
Costa, Henrique de Oliveira [UNIFESP]
Damiao, Roberio de Sousa [UNIFESP]
Gomes, Thiago Simao [UNIFESP]
Goncalves, Wagner Jose [UNIFESP]
dc.subject.por.fl_str_mv beta-catenin
Wnt5a
Wnt
Frizzled
ovarian cancer
topic beta-catenin
Wnt5a
Wnt
Frizzled
ovarian cancer
description The Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer.
publishDate 2009
dc.date.none.fl_str_mv 2009-02-01
2016-01-24T13:52:13Z
2016-01-24T13:52:13Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3892/or_00000223
Oncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 313-320, 2009.
10.3892/or_00000223
1021-335X
http://repositorio.unifesp.br/handle/11600/31273
WOS:000262679300006
url http://dx.doi.org/10.3892/or_00000223
http://repositorio.unifesp.br/handle/11600/31273
identifier_str_mv Oncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 313-320, 2009.
10.3892/or_00000223
1021-335X
WOS:000262679300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oncology Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 313-320
dc.publisher.none.fl_str_mv Spandidos Publ Ltd
publisher.none.fl_str_mv Spandidos Publ Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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