Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.3892/or_00000223 http://repositorio.unifesp.br/handle/11600/31273 |
Resumo: | The Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer. |
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Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancerbeta-cateninWnt5aWntFrizzledovarian cancerThe Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer.Universidade Federal de São Paulo, Dept Gynecol, Discipline Gynecol Oncol, BR-01424000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-01424000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Gynecol, Discipline Gynecol Oncol, BR-01424000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-01424000 São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 06/51401-1Spandidos Publ LtdUniversidade Federal de São Paulo (UNIFESP)Badiglian Filho, Levon [UNIFESP]Oshima, Celina Tizuko Fujiyama [UNIFESP]Lima, Flavio de Oliveira [UNIFESP]Costa, Henrique de Oliveira [UNIFESP]Damiao, Roberio de Sousa [UNIFESP]Gomes, Thiago Simao [UNIFESP]Goncalves, Wagner Jose [UNIFESP]2016-01-24T13:52:13Z2016-01-24T13:52:13Z2009-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion313-320http://dx.doi.org/10.3892/or_00000223Oncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 313-320, 2009.10.3892/or_000002231021-335Xhttp://repositorio.unifesp.br/handle/11600/31273WOS:000262679300006engOncology Reportsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T11:52:13Zoai:repositorio.unifesp.br/:11600/31273Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T11:52:13Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer |
title |
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer |
spellingShingle |
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer Badiglian Filho, Levon [UNIFESP] beta-catenin Wnt5a Wnt Frizzled ovarian cancer |
title_short |
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer |
title_full |
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer |
title_fullStr |
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer |
title_full_unstemmed |
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer |
title_sort |
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer |
author |
Badiglian Filho, Levon [UNIFESP] |
author_facet |
Badiglian Filho, Levon [UNIFESP] Oshima, Celina Tizuko Fujiyama [UNIFESP] Lima, Flavio de Oliveira [UNIFESP] Costa, Henrique de Oliveira [UNIFESP] Damiao, Roberio de Sousa [UNIFESP] Gomes, Thiago Simao [UNIFESP] Goncalves, Wagner Jose [UNIFESP] |
author_role |
author |
author2 |
Oshima, Celina Tizuko Fujiyama [UNIFESP] Lima, Flavio de Oliveira [UNIFESP] Costa, Henrique de Oliveira [UNIFESP] Damiao, Roberio de Sousa [UNIFESP] Gomes, Thiago Simao [UNIFESP] Goncalves, Wagner Jose [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Badiglian Filho, Levon [UNIFESP] Oshima, Celina Tizuko Fujiyama [UNIFESP] Lima, Flavio de Oliveira [UNIFESP] Costa, Henrique de Oliveira [UNIFESP] Damiao, Roberio de Sousa [UNIFESP] Gomes, Thiago Simao [UNIFESP] Goncalves, Wagner Jose [UNIFESP] |
dc.subject.por.fl_str_mv |
beta-catenin Wnt5a Wnt Frizzled ovarian cancer |
topic |
beta-catenin Wnt5a Wnt Frizzled ovarian cancer |
description |
The Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-02-01 2016-01-24T13:52:13Z 2016-01-24T13:52:13Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3892/or_00000223 Oncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 313-320, 2009. 10.3892/or_00000223 1021-335X http://repositorio.unifesp.br/handle/11600/31273 WOS:000262679300006 |
url |
http://dx.doi.org/10.3892/or_00000223 http://repositorio.unifesp.br/handle/11600/31273 |
identifier_str_mv |
Oncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 313-320, 2009. 10.3892/or_00000223 1021-335X WOS:000262679300006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oncology Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
313-320 |
dc.publisher.none.fl_str_mv |
Spandidos Publ Ltd |
publisher.none.fl_str_mv |
Spandidos Publ Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268398238957568 |