Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication

Aghamohammadi, Asghar; Abolhassani, Hassan; Kutukculer, Necil; Wassilak, Steve G.; Pallansch, Mark A.; Kluglein, Samantha; Quinn, Jessica; Sutter, Roland W.; Wang, Xiaochuan; Sanal, Ozden; Latysheva, Tatiana; Ikinciogullari, Aydan; Bernatowska, Ewa; Tuzankina, Irina A.; Costa-Carvalho, Beatriz T. [UNIFESP]; Luis Franco, Jose; Somech, Raz; Karakoc-Aydiner, Elif; Singh, Surjit; Bezrodnik, Liliana; Espinosa-Rosales, Francisco J.; Shcherbina, Anna; Lau, Yu-Lung; Nonoyama, Shigeaki; Modell, Fred; Modell, Vicki; Barbouche, Mohamed-Ridha; McKinlay, Mark A.

Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication

Detalhes bibliográficos
Autor(a) principal:	Aghamohammadi, Asghar
Data de Publicação:	2017
Outros Autores:	Abolhassani, Hassan, Kutukculer, Necil, Wassilak, Steve G., Pallansch, Mark A., Kluglein, Samantha, Quinn, Jessica, Sutter, Roland W., Wang, Xiaochuan, Sanal, Ozden, Latysheva, Tatiana, Ikinciogullari, Aydan, Bernatowska, Ewa, Tuzankina, Irina A., Costa-Carvalho, Beatriz T. [UNIFESP], Luis Franco, Jose, Somech, Raz, Karakoc-Aydiner, Elif, Singh, Surjit, Bezrodnik, Liliana, Espinosa-Rosales, Francisco J., Shcherbina, Anna, Lau, Yu-Lung, Nonoyama, Shigeaki, Modell, Fred, Modell, Vicki, Barbouche, Mohamed-Ridha, McKinlay, Mark A.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da UNIFESP
Texto Completo:	http://dx.doi.org/10.3389/fimmu.2017.00685 https://repositorio.unifesp.br/handle/11600/53661
Resumo:	Immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV). Patients may excrete poliovirus strains for months or years

Metadados do item

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network_acronym_str	UFSP
network_name_str	Repositório Institucional da UNIFESP
repository_id_str	3465
spelling	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradicationpoliovirus eradicationimmunodeficiency-associated vaccine-derived poliovirusesoral poliovirus vaccinehumoral immunodeficiencycombined immunodeficiencyprimary immunodeficiencyImmunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV). Patients may excrete poliovirus strains for months or yearsthe excreted viruses are frequently highly divergent from the parental OPV and have been shown to be as neurovirulent as wild virus. Thus, these patients represent a potential reservoir for transmission of neurovirulent polioviruses in the post-eradication era. In support of WHO recommendations to better estimate the prevalence of poliovirus excreters among PIDs and characterize genetic evolution of these strains, 635 patients including 570 with primary antibody deficiencies and 65 combined immunodeficiencies were studied from 13 OPV-using countries. Two stool samples were collected over 4 days, tested for enterovirus, and the poliovirus positive samples were sequenced. Thirteen patients (2%) excreted polioviruses, most for less than 2 months following identification of infection. Five (0.8%) were classified as iVDPVs (only in combined immunodeficiencies and mostly poliovirus serotype 2). Non-polio enteroviruses were detected in 30 patients (4.7%). Patients with combined immunodeficiencies had increased risk of delayed poliovirus clearance compared to primary antibody deficiencies. Usually, iVDPV was detected in subjects with combined immunodeficiencies in a short period of time after OPV exposure, most for less than 6 months. Surveillance for poliovirus excretion among PID patients should be reinforced until polio eradication is certified and the use of OPV is stopped. Survival rates among PID patients are improving in lower and middle income countries, and iVDPV excreters are identified more frequently. Antivirals or enhanced immunotherapies presently in development represent the only potential means to manage the treatment of prolonged excreters and the risk they present to the polio endgame.Univ Tehran Med Sci, Childrens Med Ctr, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Tehran, IranEge Univ, Dept Pediat Immunol, Fac Med, Izmir, TurkeyCtr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA USACtr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USACtr Vaccine Equ, Task Force Global Hlth, Atlanta, GA USAJeffrey Modell Fdn, New York, NY USAWHO, Res & Product Dev, Geneva, SwitzerlandFudan Univ, Childrens Hosp, Dept Clin Immunol, Shanghai, Peoples R ChinaHacettepe Univ, Fac Med, Dept Pediat, Div Immunol, Ankara, TurkeyInst Immunol, Dept Allergol & Immunotherapy, Moscow, RussiaAnkara Univ, Sch Med, Dept Pediat Immunol & Allergy, Ankara, TurkeyChildrens Mem Hlth Inst, Dept Clin Immunol, Warsaw, PolandRussian Acad Sci, Ural Branch, Inst Immunol & Physiol, Ekaterinburg, RussiaUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, BrazilUniv Antioquia, Dept Microbiol & Parasitol, Fac Med, Grp Inmunodeficiencias Primarias, Medellin, ColombiaTel Aviv Univ, Pediat Dept A, Tel Aviv, IsraelTel Aviv Univ, Affiliated Sackler Fac Med, Jeffrey Modell Fdn Ctr, Sheba Med Ctr,Immunol Serv, Tel Aviv, IsraelMarmara Med Fac, Div Pediat Allergy & Immunol, Istanbul, TurkeyPGIMER, Adv Pediat Ctr, Pediat Allergy & Immunol Unit, Chandigarh, IndiaRicardo Gutierrez Hosp Ninos, Buenos Aires, DF, ArgentinaInst Nacl Pediatria, Clin Immunol & Allergy Unit, Mexico City, DF, MexicoDmitry Rogachev Fed Res, Dept Clin Immunol, Moscow, RussiaClin Ctr Pediat Hematol Oncol & Immunol, Moscow, RussiaUniv Hong Kong, Queen Mary Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Shenzhen Hosp, Shenzhen Primary Immunodeficiency Diagnost & Ther, Shenzhen, Peoples R ChinaNatl Def Med Coll, Dept Pediat, Saitama, JapanUniv Tunis El Manar, Inst Pasteur Tunis, Dept Immunol, Tunis, TunisiaUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, BrazilWeb of ScienceBill & Melinda Gates FoundationBill & Melinda Gates FoundationFrontiers Media Sa2020-06-26T16:30:37Z2020-06-26T16:30:37Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.3389/fimmu.2017.00685Frontiers In Immunology. Lausanne, v. 8, p. -, 2017.10.3389/fimmu.2017.00685WOS000403113800002.pdf1664-3224https://repositorio.unifesp.br/handle/11600/53661WOS:000403113800002engFrontiers In ImmunologyLausanneinfo:eu-repo/semantics/openAccessAghamohammadi, AsgharAbolhassani, HassanKutukculer, NecilWassilak, Steve G.Pallansch, Mark A.Kluglein, SamanthaQuinn, JessicaSutter, Roland W.Wang, XiaochuanSanal, OzdenLatysheva, TatianaIkinciogullari, AydanBernatowska, EwaTuzankina, Irina A.Costa-Carvalho, Beatriz T. [UNIFESP]Luis Franco, JoseSomech, RazKarakoc-Aydiner, ElifSingh, SurjitBezrodnik, LilianaEspinosa-Rosales, Francisco J.Shcherbina, AnnaLau, Yu-LungNonoyama, ShigeakiModell, FredModell, VickiBarbouche, Mohamed-RidhaMcKinlay, Mark A.reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T01:52:00Zoai:repositorio.unifesp.br/:11600/53661Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T01:52Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
title	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
spellingShingle	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication Aghamohammadi, Asghar poliovirus eradication immunodeficiency-associated vaccine-derived polioviruses oral poliovirus vaccine humoral immunodeficiency combined immunodeficiency primary immunodeficiency
title_short	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
title_full	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
title_fullStr	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
title_full_unstemmed	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
title_sort	Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
author	Aghamohammadi, Asghar
author_facet	Aghamohammadi, Asghar Abolhassani, Hassan Kutukculer, Necil Wassilak, Steve G. Pallansch, Mark A. Kluglein, Samantha Quinn, Jessica Sutter, Roland W. Wang, Xiaochuan Sanal, Ozden Latysheva, Tatiana Ikinciogullari, Aydan Bernatowska, Ewa Tuzankina, Irina A. Costa-Carvalho, Beatriz T. [UNIFESP] Luis Franco, Jose Somech, Raz Karakoc-Aydiner, Elif Singh, Surjit Bezrodnik, Liliana Espinosa-Rosales, Francisco J. Shcherbina, Anna Lau, Yu-Lung Nonoyama, Shigeaki Modell, Fred Modell, Vicki Barbouche, Mohamed-Ridha McKinlay, Mark A.
author_role	author
author2	Abolhassani, Hassan Kutukculer, Necil Wassilak, Steve G. Pallansch, Mark A. Kluglein, Samantha Quinn, Jessica Sutter, Roland W. Wang, Xiaochuan Sanal, Ozden Latysheva, Tatiana Ikinciogullari, Aydan Bernatowska, Ewa Tuzankina, Irina A. Costa-Carvalho, Beatriz T. [UNIFESP] Luis Franco, Jose Somech, Raz Karakoc-Aydiner, Elif Singh, Surjit Bezrodnik, Liliana Espinosa-Rosales, Francisco J. Shcherbina, Anna Lau, Yu-Lung Nonoyama, Shigeaki Modell, Fred Modell, Vicki Barbouche, Mohamed-Ridha McKinlay, Mark A.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Aghamohammadi, Asghar Abolhassani, Hassan Kutukculer, Necil Wassilak, Steve G. Pallansch, Mark A. Kluglein, Samantha Quinn, Jessica Sutter, Roland W. Wang, Xiaochuan Sanal, Ozden Latysheva, Tatiana Ikinciogullari, Aydan Bernatowska, Ewa Tuzankina, Irina A. Costa-Carvalho, Beatriz T. [UNIFESP] Luis Franco, Jose Somech, Raz Karakoc-Aydiner, Elif Singh, Surjit Bezrodnik, Liliana Espinosa-Rosales, Francisco J. Shcherbina, Anna Lau, Yu-Lung Nonoyama, Shigeaki Modell, Fred Modell, Vicki Barbouche, Mohamed-Ridha McKinlay, Mark A.
dc.subject.por.fl_str_mv	poliovirus eradication immunodeficiency-associated vaccine-derived polioviruses oral poliovirus vaccine humoral immunodeficiency combined immunodeficiency primary immunodeficiency
topic	poliovirus eradication immunodeficiency-associated vaccine-derived polioviruses oral poliovirus vaccine humoral immunodeficiency combined immunodeficiency primary immunodeficiency
description	Immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV). Patients may excrete poliovirus strains for months or years
publishDate	2017
dc.date.none.fl_str_mv	2017 2020-06-26T16:30:37Z 2020-06-26T16:30:37Z
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://dx.doi.org/10.3389/fimmu.2017.00685 Frontiers In Immunology. Lausanne, v. 8, p. -, 2017. 10.3389/fimmu.2017.00685 WOS000403113800002.pdf 1664-3224 https://repositorio.unifesp.br/handle/11600/53661 WOS:000403113800002
url	http://dx.doi.org/10.3389/fimmu.2017.00685 https://repositorio.unifesp.br/handle/11600/53661
identifier_str_mv	Frontiers In Immunology. Lausanne, v. 8, p. -, 2017. 10.3389/fimmu.2017.00685 WOS000403113800002.pdf 1664-3224 WOS:000403113800002
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Frontiers In Immunology
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	- application/pdf
dc.coverage.none.fl_str_mv	Lausanne
dc.publisher.none.fl_str_mv	Frontiers Media Sa
publisher.none.fl_str_mv	Frontiers Media Sa
dc.source.none.fl_str_mv	reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP
instname_str	Universidade Federal de São Paulo (UNIFESP)
instacron_str	UNIFESP
institution	UNIFESP
reponame_str	Repositório Institucional da UNIFESP
collection	Repositório Institucional da UNIFESP
repository.name.fl_str_mv	Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv	biblioteca.csp@unifesp.br
_version_	1814268289729167360

Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication

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