Baixa prevalência das manifestações extra-articulares renais, cardíacas, pulmonares e neurológicas nas espondiloartrites: análise do Registro Brasileiro de Espondiloartrites

• Autor(a) principal: Rodrigues, Carlos Ewerton Maia
• Data de Publicação: 2012
• Outros Autores: Vieira, Walber Pinto, Bortoluzzo, Adriana Bruscato, Gonçalves, Célio Roberto, Silva, José Antonio Braga da, Ximenes, Antônio Carlos, Bertolo, Manoel Barros, Ribeiro, Sandra Lúcia Euzébio [UNIFESP], Keiserman, Mauro Waldemar, Menin, Rita, Skare, Thelma Larocca, Carneiro, Sueli Coelho da Silva, Azevedo, Valderílio Feijó, Albuquerque, Elisa Martins das Neves de, Bianchi, Washington Alves, Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen Mary da Silveira de, Costa, Izaias Pereira da, Duarte, Angela Luzia Branco Pinto [UNIFESP], Kohem, Charles Lubianca, Leite, Nocy Honorato, Lima, Sonia Anti Loduca, Meirelles, Eduardo de Souza, Pereira, Ivânio Alves, Pinheiro, Marcelo de Medeiros [UNIFESP], Polito, Elizandra, Resende, Gustavo Gomes, Rocha, Francisco Airton Castro da, Santiago, Mittermayer Barreto, Sauma, Maria de Fátima Lobato da Cunha, Valim, Valeria [UNIFESP], Sampaio-Barros, Percival Degrava
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0482-50042012000300008; http://repositorio.unifesp.br/handle/11600/7169
• topic: spondylitis; neurology; cardiology; pulmonary medicine; nephrology; espondiloartropatias; neurologia; cardiologia; pneumologia; nefrologia

OBJECTIVE: To describe the extra-articular manifestations (cardiac, renal, pulmonary, and neurological), usually not related to spondyloarthritis (SpA), in a large cohort of Brazilian patients. MATERIALS AND METHODS: This retrospective study analyzed 1,472 patients diagnosed with SpA and cared for at 29 health care centers distributed in the five major geographic regions in the country, participating in the Brazilian Registry of Spondyloarthritis (BRS). All patients were assessed for the prevalence of major extra-articular manifestations (cardiac, renal, pulmonary, and neurological), classified according to the diagnosis [ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease (IBD), undifferentiated spondyloarthritis (uSpA), and juvenile SpA], and according to the clinical presentation (axial, peripheral, mixed, and enthesitis). RESULTS: Of the patients with SpA assessed, 963 had AS, 271 PsA, 49 ReA, 48 arthritis associated with IBD, 98 uSpA, and 43 juvenile SpA. Cardiac involvement was reported in 44 patients (3.0%), pulmonary involvement in 19 (1.3%), renal involvement in 17 (1.2%), and neurological involvement in 13 patients (0.9%). Most patients with visceral involvement had AS or PsA, and the mixed (axial + peripheral) and/or predominantly axial clinical form. CONCLUSION: Cardiac, renal, pulmonary, and neurological extra-articular manifestations are quite infrequent in SpA, ranging from 0.9% to 3% in this large Brazilian cohort, and affected predominantly patients with AS and PsA.