Idiopathic focal segmental glomerulosclerosis and HLA antigens

• Autor(a) principal: Gerbase-Lima, Maria [UNIFESP]
• Data de Publicação: 1998
• Outros Autores: Pereira-Santos, A. [UNIFESP], Sesso, Ricardo de Castro Cintra [UNIFESP], Temin, Julia, Aragão, E.s., Ajzen, Horacio [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/001300000qn2d
• Texto Completo: http://dx.doi.org/10.1590/S0100-879X1998000300010; http://repositorio.unifesp.br/handle/11600/590
• topic: focal segmental glomerulosclerosis; genetics; HLA antigens; MHC

The objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS). HLA-A, -B, -DR and -DQ antigens were determined in 19 Brazilian patients (16 white subjects and three subjects of Japanese origin) with biopsy-proven FSGS. Comparison of the HLA antigen frequencies between white patients and white local controls showed a significant increase in HLA-DR4 frequency among FSGS patients (37.7 vs 17.2%, P<0.05). In addition, the three patients of Japanese extraction, not included in the statistical analysis, also presented HLA-DR4. In conclusion, our data confirm the association of FSGS with HLA-DR4 previously reported by others, thus providing further evidence for a role of genes of the HLA complex in the susceptibility to this disease