EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE

Detalhes bibliográficos
Autor(a) principal: Brianezi, Ledimar
Data de Publicação: 2017
Outros Autores: Marques, Mara Rubia, Cardoso, Clever Gomes, de Jesus Miranda, Maria Luiza, Affonso Fonseca, Fernando Luiz [UNIFESP], Mesiano Maifrino, Laura Beatriz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/1517-869220172306160084
https://repositorio.unifesp.br/handle/11600/58208
Resumo: Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.
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spelling EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICEheart ventriclesexercisemenopauseIntroduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.Univ Sao Judas Tadeu, Programa Posgrad, Sao Paulo, SP, BrazilFac Adventista Hortolandia UNASP, Campus Hortolandia, Hortolandia, SP, BrazilUniv Fed Goias, Dept Histol Embriol & Biol Mol, Goiania, Go, BrazilFMABC, Lab Anal Clin, Santo Andre, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Ciencias Biol, Diadema, SP, BrazilInst Dante Pazzanese Cardiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Ciencias Biol, Diadema, SP, BrazilWeb of ScienceSoc Brasileira Med Esporte2020-09-01T13:21:20Z2020-09-01T13:21:20Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion441-445application/pdfhttp://dx.doi.org/10.1590/1517-869220172306160084Revista Brasileira De Medicina Do Esporte. Sao Paulo Sp, v. 23, n. 6, p. 441-445, 2017.10.1590/1517-869220172306160084S1517-86922017000600441.pdf1517-8692S1517-86922017000600441https://repositorio.unifesp.br/handle/11600/58208WOS:000418605800003engRevista Brasileira De Medicina Do EsporteSao Paulo Spinfo:eu-repo/semantics/openAccessBrianezi, LedimarMarques, Mara RubiaCardoso, Clever Gomesde Jesus Miranda, Maria LuizaAffonso Fonseca, Fernando Luiz [UNIFESP]Mesiano Maifrino, Laura Beatrizreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T22:47:24Zoai:repositorio.unifesp.br/:11600/58208Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T22:47:24Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
title EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
spellingShingle EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
Brianezi, Ledimar
heart ventricles
exercise
menopause
title_short EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
title_full EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
title_fullStr EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
title_full_unstemmed EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
title_sort EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
author Brianezi, Ledimar
author_facet Brianezi, Ledimar
Marques, Mara Rubia
Cardoso, Clever Gomes
de Jesus Miranda, Maria Luiza
Affonso Fonseca, Fernando Luiz [UNIFESP]
Mesiano Maifrino, Laura Beatriz
author_role author
author2 Marques, Mara Rubia
Cardoso, Clever Gomes
de Jesus Miranda, Maria Luiza
Affonso Fonseca, Fernando Luiz [UNIFESP]
Mesiano Maifrino, Laura Beatriz
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Brianezi, Ledimar
Marques, Mara Rubia
Cardoso, Clever Gomes
de Jesus Miranda, Maria Luiza
Affonso Fonseca, Fernando Luiz [UNIFESP]
Mesiano Maifrino, Laura Beatriz
dc.subject.por.fl_str_mv heart ventricles
exercise
menopause
topic heart ventricles
exercise
menopause
description Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-09-01T13:21:20Z
2020-09-01T13:21:20Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1517-869220172306160084
Revista Brasileira De Medicina Do Esporte. Sao Paulo Sp, v. 23, n. 6, p. 441-445, 2017.
10.1590/1517-869220172306160084
S1517-86922017000600441.pdf
1517-8692
S1517-86922017000600441
https://repositorio.unifesp.br/handle/11600/58208
WOS:000418605800003
url http://dx.doi.org/10.1590/1517-869220172306160084
https://repositorio.unifesp.br/handle/11600/58208
identifier_str_mv Revista Brasileira De Medicina Do Esporte. Sao Paulo Sp, v. 23, n. 6, p. 441-445, 2017.
10.1590/1517-869220172306160084
S1517-86922017000600441.pdf
1517-8692
S1517-86922017000600441
WOS:000418605800003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira De Medicina Do Esporte
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 441-445
application/pdf
dc.coverage.none.fl_str_mv Sao Paulo Sp
dc.publisher.none.fl_str_mv Soc Brasileira Med Esporte
publisher.none.fl_str_mv Soc Brasileira Med Esporte
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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