EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/1517-869220172306160084 https://repositorio.unifesp.br/handle/11600/58208 |
Resumo: | Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group. |
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EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICEheart ventriclesexercisemenopauseIntroduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.Univ Sao Judas Tadeu, Programa Posgrad, Sao Paulo, SP, BrazilFac Adventista Hortolandia UNASP, Campus Hortolandia, Hortolandia, SP, BrazilUniv Fed Goias, Dept Histol Embriol & Biol Mol, Goiania, Go, BrazilFMABC, Lab Anal Clin, Santo Andre, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Ciencias Biol, Diadema, SP, BrazilInst Dante Pazzanese Cardiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Ciencias Biol, Diadema, SP, BrazilWeb of ScienceSoc Brasileira Med Esporte2020-09-01T13:21:20Z2020-09-01T13:21:20Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion441-445application/pdfhttp://dx.doi.org/10.1590/1517-869220172306160084Revista Brasileira De Medicina Do Esporte. Sao Paulo Sp, v. 23, n. 6, p. 441-445, 2017.10.1590/1517-869220172306160084S1517-86922017000600441.pdf1517-8692S1517-86922017000600441https://repositorio.unifesp.br/handle/11600/58208WOS:000418605800003engRevista Brasileira De Medicina Do EsporteSao Paulo Spinfo:eu-repo/semantics/openAccessBrianezi, LedimarMarques, Mara RubiaCardoso, Clever Gomesde Jesus Miranda, Maria LuizaAffonso Fonseca, Fernando Luiz [UNIFESP]Mesiano Maifrino, Laura Beatrizreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T22:47:24Zoai:repositorio.unifesp.br/:11600/58208Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T22:47:24Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE |
title |
EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE |
spellingShingle |
EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE Brianezi, Ledimar heart ventricles exercise menopause |
title_short |
EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE |
title_full |
EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE |
title_fullStr |
EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE |
title_full_unstemmed |
EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE |
title_sort |
EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE |
author |
Brianezi, Ledimar |
author_facet |
Brianezi, Ledimar Marques, Mara Rubia Cardoso, Clever Gomes de Jesus Miranda, Maria Luiza Affonso Fonseca, Fernando Luiz [UNIFESP] Mesiano Maifrino, Laura Beatriz |
author_role |
author |
author2 |
Marques, Mara Rubia Cardoso, Clever Gomes de Jesus Miranda, Maria Luiza Affonso Fonseca, Fernando Luiz [UNIFESP] Mesiano Maifrino, Laura Beatriz |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Brianezi, Ledimar Marques, Mara Rubia Cardoso, Clever Gomes de Jesus Miranda, Maria Luiza Affonso Fonseca, Fernando Luiz [UNIFESP] Mesiano Maifrino, Laura Beatriz |
dc.subject.por.fl_str_mv |
heart ventricles exercise menopause |
topic |
heart ventricles exercise menopause |
description |
Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2020-09-01T13:21:20Z 2020-09-01T13:21:20Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1517-869220172306160084 Revista Brasileira De Medicina Do Esporte. Sao Paulo Sp, v. 23, n. 6, p. 441-445, 2017. 10.1590/1517-869220172306160084 S1517-86922017000600441.pdf 1517-8692 S1517-86922017000600441 https://repositorio.unifesp.br/handle/11600/58208 WOS:000418605800003 |
url |
http://dx.doi.org/10.1590/1517-869220172306160084 https://repositorio.unifesp.br/handle/11600/58208 |
identifier_str_mv |
Revista Brasileira De Medicina Do Esporte. Sao Paulo Sp, v. 23, n. 6, p. 441-445, 2017. 10.1590/1517-869220172306160084 S1517-86922017000600441.pdf 1517-8692 S1517-86922017000600441 WOS:000418605800003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira De Medicina Do Esporte |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
441-445 application/pdf |
dc.coverage.none.fl_str_mv |
Sao Paulo Sp |
dc.publisher.none.fl_str_mv |
Soc Brasileira Med Esporte |
publisher.none.fl_str_mv |
Soc Brasileira Med Esporte |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268355558768640 |