Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population

Detalhes bibliográficos
Autor(a) principal: Carvalho, Beatriz T Costa
Data de Publicação: 1999
Outros Autores: Carneiro-Sampaio, Magda Maria Sales [UNIFESP], Solé, Dirceu [UNIFESP], Naspitz, Charles Kirov [UNIFESP], Leiva, Lily E., Sorensen, Ricardo Uhr
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000002rhr
Texto Completo: http://cvi.asm.org/content/6/1/50.abstract
http://repositorio.unifesp.br/handle/11600/43280
Resumo: The highest incidence of severe pneumococcal infections in children occurs In the first 6 months of life; however, immunization of infants with the existing polysaccharide vaccines is ineffective. We wished to determine the prevalence of immunoglobulin G (IgG) pneumococcal antibodies in unimmunized Brazilian mothers and their transplacental transmission to term and preterm infants. Total IgG, IgC1 and -2 subclass levels, and IgG antibodies against Streptococcus pneumoniae serotypes 1, 3, 6B, 9V, and 14 were determined in 15 pairs of mothers and term newborns (gestational age, greater than or equal to 37 weeks) and in 18 pairs of mothers and preterm newborns (gestational age, 32 to 36 weeks). Serotype-specific anti-pneumococcal antibodies were detected by a recently standardized enzyme-linked immunosorbent assay calibrated with the 89-SF reference serum, Varying percentages of the mothers had antibody concentrations below arbitrarily defined protective levels: 33% for serotype 1, 67% for serotype 3, 30% for serotype 6B, 52% for serotype 9V, and 22% for serotype 14. In term newborns, IgG1 concentrations were slightly higher than maternal concentrations; in preterm newborns, the concentrations were much lower, Concentrations of IgG2 in term and preterm infants were significantly lower than in the mothers, Transplacental transmission of antibodies to serotypes 3 and 14 was clearly different from that of antibodies to serotypes 1, 6B, and 9V, Concentrations of Ige antibodies against serotypes 3 and 14 were similar to or higher than those of the mothers; against serotypes 1, 6B, and 9V they ranged from 77 to 83% of maternal concentrations in term newborns and also in preterm infants, although transplacental transmission of antibodies was proportionally lower for each specific serotype in preterm than in term infants. These data are relevant for developing strategies to protect infants against pneumococcal infections in the first months of life. Our findings and a review of existing information stress the importance of understanding the relationships among pneumococcal immunization, IgG subclass antibodies to individual serotypes, transplacental transport, half-life, and antibody function and their protective values against infection.
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spelling Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian populationThe highest incidence of severe pneumococcal infections in children occurs In the first 6 months of life; however, immunization of infants with the existing polysaccharide vaccines is ineffective. We wished to determine the prevalence of immunoglobulin G (IgG) pneumococcal antibodies in unimmunized Brazilian mothers and their transplacental transmission to term and preterm infants. Total IgG, IgC1 and -2 subclass levels, and IgG antibodies against Streptococcus pneumoniae serotypes 1, 3, 6B, 9V, and 14 were determined in 15 pairs of mothers and term newborns (gestational age, greater than or equal to 37 weeks) and in 18 pairs of mothers and preterm newborns (gestational age, 32 to 36 weeks). Serotype-specific anti-pneumococcal antibodies were detected by a recently standardized enzyme-linked immunosorbent assay calibrated with the 89-SF reference serum, Varying percentages of the mothers had antibody concentrations below arbitrarily defined protective levels: 33% for serotype 1, 67% for serotype 3, 30% for serotype 6B, 52% for serotype 9V, and 22% for serotype 14. In term newborns, IgG1 concentrations were slightly higher than maternal concentrations; in preterm newborns, the concentrations were much lower, Concentrations of IgG2 in term and preterm infants were significantly lower than in the mothers, Transplacental transmission of antibodies to serotypes 3 and 14 was clearly different from that of antibodies to serotypes 1, 6B, and 9V, Concentrations of Ige antibodies against serotypes 3 and 14 were similar to or higher than those of the mothers; against serotypes 1, 6B, and 9V they ranged from 77 to 83% of maternal concentrations in term newborns and also in preterm infants, although transplacental transmission of antibodies was proportionally lower for each specific serotype in preterm than in term infants. These data are relevant for developing strategies to protect infants against pneumococcal infections in the first months of life. Our findings and a review of existing information stress the importance of understanding the relationships among pneumococcal immunization, IgG subclass antibodies to individual serotypes, transplacental transport, half-life, and antibody function and their protective values against infection.Univ Sao Paulo, Inst Ciencias Biomed, Dept Immunol, BR-05508 Sao Paulo, BrazilLouisiana State Univ, Med Ctr, Dept Pediat, New Orleans, LA 70112 USAUNIFESP, EPM, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, BrazilUNIFESP, EPM, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, BrazilWeb of ScienceAmer Soc MicrobiologyUniversidade de São Paulo (USP)Louisiana State UnivUniversidade Federal de São Paulo (UNIFESP)Carvalho, Beatriz T CostaCarneiro-Sampaio, Magda Maria Sales [UNIFESP]Solé, Dirceu [UNIFESP]Naspitz, Charles Kirov [UNIFESP]Leiva, Lily E.Sorensen, Ricardo Uhr2018-06-15T16:39:18Z2018-06-15T16:39:18Z1999-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion50-54http://cvi.asm.org/content/6/1/50.abstractClinical And Diagnostic Laboratory Immunology. Washington: Amer Soc Microbiology, v. 6, n. 1, p. 50-54, 1999.1071-412Xhttp://repositorio.unifesp.br/handle/11600/43280WOS:000077980900009ark:/48912/0013000002rhrengClinical And Diagnostic Laboratory Immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:59:25Zoai:repositorio.unifesp.br/:11600/43280Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:53:14.823457Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
title Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
spellingShingle Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
Carvalho, Beatriz T Costa
title_short Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
title_full Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
title_fullStr Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
title_full_unstemmed Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
title_sort Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
author Carvalho, Beatriz T Costa
author_facet Carvalho, Beatriz T Costa
Carneiro-Sampaio, Magda Maria Sales [UNIFESP]
Solé, Dirceu [UNIFESP]
Naspitz, Charles Kirov [UNIFESP]
Leiva, Lily E.
Sorensen, Ricardo Uhr
author_role author
author2 Carneiro-Sampaio, Magda Maria Sales [UNIFESP]
Solé, Dirceu [UNIFESP]
Naspitz, Charles Kirov [UNIFESP]
Leiva, Lily E.
Sorensen, Ricardo Uhr
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Louisiana State Univ
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Carvalho, Beatriz T Costa
Carneiro-Sampaio, Magda Maria Sales [UNIFESP]
Solé, Dirceu [UNIFESP]
Naspitz, Charles Kirov [UNIFESP]
Leiva, Lily E.
Sorensen, Ricardo Uhr
description The highest incidence of severe pneumococcal infections in children occurs In the first 6 months of life; however, immunization of infants with the existing polysaccharide vaccines is ineffective. We wished to determine the prevalence of immunoglobulin G (IgG) pneumococcal antibodies in unimmunized Brazilian mothers and their transplacental transmission to term and preterm infants. Total IgG, IgC1 and -2 subclass levels, and IgG antibodies against Streptococcus pneumoniae serotypes 1, 3, 6B, 9V, and 14 were determined in 15 pairs of mothers and term newborns (gestational age, greater than or equal to 37 weeks) and in 18 pairs of mothers and preterm newborns (gestational age, 32 to 36 weeks). Serotype-specific anti-pneumococcal antibodies were detected by a recently standardized enzyme-linked immunosorbent assay calibrated with the 89-SF reference serum, Varying percentages of the mothers had antibody concentrations below arbitrarily defined protective levels: 33% for serotype 1, 67% for serotype 3, 30% for serotype 6B, 52% for serotype 9V, and 22% for serotype 14. In term newborns, IgG1 concentrations were slightly higher than maternal concentrations; in preterm newborns, the concentrations were much lower, Concentrations of IgG2 in term and preterm infants were significantly lower than in the mothers, Transplacental transmission of antibodies to serotypes 3 and 14 was clearly different from that of antibodies to serotypes 1, 6B, and 9V, Concentrations of Ige antibodies against serotypes 3 and 14 were similar to or higher than those of the mothers; against serotypes 1, 6B, and 9V they ranged from 77 to 83% of maternal concentrations in term newborns and also in preterm infants, although transplacental transmission of antibodies was proportionally lower for each specific serotype in preterm than in term infants. These data are relevant for developing strategies to protect infants against pneumococcal infections in the first months of life. Our findings and a review of existing information stress the importance of understanding the relationships among pneumococcal immunization, IgG subclass antibodies to individual serotypes, transplacental transport, half-life, and antibody function and their protective values against infection.
publishDate 1999
dc.date.none.fl_str_mv 1999-01-01
2018-06-15T16:39:18Z
2018-06-15T16:39:18Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://cvi.asm.org/content/6/1/50.abstract
Clinical And Diagnostic Laboratory Immunology. Washington: Amer Soc Microbiology, v. 6, n. 1, p. 50-54, 1999.
1071-412X
http://repositorio.unifesp.br/handle/11600/43280
WOS:000077980900009
dc.identifier.dark.fl_str_mv ark:/48912/0013000002rhr
url http://cvi.asm.org/content/6/1/50.abstract
http://repositorio.unifesp.br/handle/11600/43280
identifier_str_mv Clinical And Diagnostic Laboratory Immunology. Washington: Amer Soc Microbiology, v. 6, n. 1, p. 50-54, 1999.
1071-412X
WOS:000077980900009
ark:/48912/0013000002rhr
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical And Diagnostic Laboratory Immunology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 50-54
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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