Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/0013000002rhr |
Texto Completo: | http://cvi.asm.org/content/6/1/50.abstract http://repositorio.unifesp.br/handle/11600/43280 |
Resumo: | The highest incidence of severe pneumococcal infections in children occurs In the first 6 months of life; however, immunization of infants with the existing polysaccharide vaccines is ineffective. We wished to determine the prevalence of immunoglobulin G (IgG) pneumococcal antibodies in unimmunized Brazilian mothers and their transplacental transmission to term and preterm infants. Total IgG, IgC1 and -2 subclass levels, and IgG antibodies against Streptococcus pneumoniae serotypes 1, 3, 6B, 9V, and 14 were determined in 15 pairs of mothers and term newborns (gestational age, greater than or equal to 37 weeks) and in 18 pairs of mothers and preterm newborns (gestational age, 32 to 36 weeks). Serotype-specific anti-pneumococcal antibodies were detected by a recently standardized enzyme-linked immunosorbent assay calibrated with the 89-SF reference serum, Varying percentages of the mothers had antibody concentrations below arbitrarily defined protective levels: 33% for serotype 1, 67% for serotype 3, 30% for serotype 6B, 52% for serotype 9V, and 22% for serotype 14. In term newborns, IgG1 concentrations were slightly higher than maternal concentrations; in preterm newborns, the concentrations were much lower, Concentrations of IgG2 in term and preterm infants were significantly lower than in the mothers, Transplacental transmission of antibodies to serotypes 3 and 14 was clearly different from that of antibodies to serotypes 1, 6B, and 9V, Concentrations of Ige antibodies against serotypes 3 and 14 were similar to or higher than those of the mothers; against serotypes 1, 6B, and 9V they ranged from 77 to 83% of maternal concentrations in term newborns and also in preterm infants, although transplacental transmission of antibodies was proportionally lower for each specific serotype in preterm than in term infants. These data are relevant for developing strategies to protect infants against pneumococcal infections in the first months of life. Our findings and a review of existing information stress the importance of understanding the relationships among pneumococcal immunization, IgG subclass antibodies to individual serotypes, transplacental transport, half-life, and antibody function and their protective values against infection. |
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Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian populationThe highest incidence of severe pneumococcal infections in children occurs In the first 6 months of life; however, immunization of infants with the existing polysaccharide vaccines is ineffective. We wished to determine the prevalence of immunoglobulin G (IgG) pneumococcal antibodies in unimmunized Brazilian mothers and their transplacental transmission to term and preterm infants. Total IgG, IgC1 and -2 subclass levels, and IgG antibodies against Streptococcus pneumoniae serotypes 1, 3, 6B, 9V, and 14 were determined in 15 pairs of mothers and term newborns (gestational age, greater than or equal to 37 weeks) and in 18 pairs of mothers and preterm newborns (gestational age, 32 to 36 weeks). Serotype-specific anti-pneumococcal antibodies were detected by a recently standardized enzyme-linked immunosorbent assay calibrated with the 89-SF reference serum, Varying percentages of the mothers had antibody concentrations below arbitrarily defined protective levels: 33% for serotype 1, 67% for serotype 3, 30% for serotype 6B, 52% for serotype 9V, and 22% for serotype 14. In term newborns, IgG1 concentrations were slightly higher than maternal concentrations; in preterm newborns, the concentrations were much lower, Concentrations of IgG2 in term and preterm infants were significantly lower than in the mothers, Transplacental transmission of antibodies to serotypes 3 and 14 was clearly different from that of antibodies to serotypes 1, 6B, and 9V, Concentrations of Ige antibodies against serotypes 3 and 14 were similar to or higher than those of the mothers; against serotypes 1, 6B, and 9V they ranged from 77 to 83% of maternal concentrations in term newborns and also in preterm infants, although transplacental transmission of antibodies was proportionally lower for each specific serotype in preterm than in term infants. These data are relevant for developing strategies to protect infants against pneumococcal infections in the first months of life. Our findings and a review of existing information stress the importance of understanding the relationships among pneumococcal immunization, IgG subclass antibodies to individual serotypes, transplacental transport, half-life, and antibody function and their protective values against infection.Univ Sao Paulo, Inst Ciencias Biomed, Dept Immunol, BR-05508 Sao Paulo, BrazilLouisiana State Univ, Med Ctr, Dept Pediat, New Orleans, LA 70112 USAUNIFESP, EPM, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, BrazilUNIFESP, EPM, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, BrazilWeb of ScienceAmer Soc MicrobiologyUniversidade de São Paulo (USP)Louisiana State UnivUniversidade Federal de São Paulo (UNIFESP)Carvalho, Beatriz T CostaCarneiro-Sampaio, Magda Maria Sales [UNIFESP]Solé, Dirceu [UNIFESP]Naspitz, Charles Kirov [UNIFESP]Leiva, Lily E.Sorensen, Ricardo Uhr2018-06-15T16:39:18Z2018-06-15T16:39:18Z1999-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion50-54http://cvi.asm.org/content/6/1/50.abstractClinical And Diagnostic Laboratory Immunology. Washington: Amer Soc Microbiology, v. 6, n. 1, p. 50-54, 1999.1071-412Xhttp://repositorio.unifesp.br/handle/11600/43280WOS:000077980900009ark:/48912/0013000002rhrengClinical And Diagnostic Laboratory Immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:59:25Zoai:repositorio.unifesp.br/:11600/43280Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:53:14.823457Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population |
title |
Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population |
spellingShingle |
Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population Carvalho, Beatriz T Costa |
title_short |
Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population |
title_full |
Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population |
title_fullStr |
Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population |
title_full_unstemmed |
Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population |
title_sort |
Transplacental transmission of serotype-specific pneumococcal antibodies in a Brazilian population |
author |
Carvalho, Beatriz T Costa |
author_facet |
Carvalho, Beatriz T Costa Carneiro-Sampaio, Magda Maria Sales [UNIFESP] Solé, Dirceu [UNIFESP] Naspitz, Charles Kirov [UNIFESP] Leiva, Lily E. Sorensen, Ricardo Uhr |
author_role |
author |
author2 |
Carneiro-Sampaio, Magda Maria Sales [UNIFESP] Solé, Dirceu [UNIFESP] Naspitz, Charles Kirov [UNIFESP] Leiva, Lily E. Sorensen, Ricardo Uhr |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Louisiana State Univ Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Carvalho, Beatriz T Costa Carneiro-Sampaio, Magda Maria Sales [UNIFESP] Solé, Dirceu [UNIFESP] Naspitz, Charles Kirov [UNIFESP] Leiva, Lily E. Sorensen, Ricardo Uhr |
description |
The highest incidence of severe pneumococcal infections in children occurs In the first 6 months of life; however, immunization of infants with the existing polysaccharide vaccines is ineffective. We wished to determine the prevalence of immunoglobulin G (IgG) pneumococcal antibodies in unimmunized Brazilian mothers and their transplacental transmission to term and preterm infants. Total IgG, IgC1 and -2 subclass levels, and IgG antibodies against Streptococcus pneumoniae serotypes 1, 3, 6B, 9V, and 14 were determined in 15 pairs of mothers and term newborns (gestational age, greater than or equal to 37 weeks) and in 18 pairs of mothers and preterm newborns (gestational age, 32 to 36 weeks). Serotype-specific anti-pneumococcal antibodies were detected by a recently standardized enzyme-linked immunosorbent assay calibrated with the 89-SF reference serum, Varying percentages of the mothers had antibody concentrations below arbitrarily defined protective levels: 33% for serotype 1, 67% for serotype 3, 30% for serotype 6B, 52% for serotype 9V, and 22% for serotype 14. In term newborns, IgG1 concentrations were slightly higher than maternal concentrations; in preterm newborns, the concentrations were much lower, Concentrations of IgG2 in term and preterm infants were significantly lower than in the mothers, Transplacental transmission of antibodies to serotypes 3 and 14 was clearly different from that of antibodies to serotypes 1, 6B, and 9V, Concentrations of Ige antibodies against serotypes 3 and 14 were similar to or higher than those of the mothers; against serotypes 1, 6B, and 9V they ranged from 77 to 83% of maternal concentrations in term newborns and also in preterm infants, although transplacental transmission of antibodies was proportionally lower for each specific serotype in preterm than in term infants. These data are relevant for developing strategies to protect infants against pneumococcal infections in the first months of life. Our findings and a review of existing information stress the importance of understanding the relationships among pneumococcal immunization, IgG subclass antibodies to individual serotypes, transplacental transport, half-life, and antibody function and their protective values against infection. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-01-01 2018-06-15T16:39:18Z 2018-06-15T16:39:18Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://cvi.asm.org/content/6/1/50.abstract Clinical And Diagnostic Laboratory Immunology. Washington: Amer Soc Microbiology, v. 6, n. 1, p. 50-54, 1999. 1071-412X http://repositorio.unifesp.br/handle/11600/43280 WOS:000077980900009 |
dc.identifier.dark.fl_str_mv |
ark:/48912/0013000002rhr |
url |
http://cvi.asm.org/content/6/1/50.abstract http://repositorio.unifesp.br/handle/11600/43280 |
identifier_str_mv |
Clinical And Diagnostic Laboratory Immunology. Washington: Amer Soc Microbiology, v. 6, n. 1, p. 50-54, 1999. 1071-412X WOS:000077980900009 ark:/48912/0013000002rhr |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical And Diagnostic Laboratory Immunology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
50-54 |
dc.publisher.none.fl_str_mv |
Amer Soc Microbiology |
publisher.none.fl_str_mv |
Amer Soc Microbiology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1818602390459252736 |