Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/33655 https://dx.doi.org/10.1128/JCM.00376-11 |
Resumo: | Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality. Data from a nationwide, concurrent surveillance study, Brazilian SCOPE (Surveillance and Control of Pathogens of Epidemiological Importance), were used to examine the epidemiology and microbiology of nBSIs at 16 Brazilian hospitals. in our study 2,563 patients with nBSIs were included from 12 June 2007 to 31 March 2010. Ninety-five percent of BSIs were monomicrobial. Gram-negative organisms caused 58.5% of these BSIs, Gram-positive organisms caused 35.4%, and fungi caused 6.1%. the most common pathogens (monomicrobial) were Staphylococcus aureus (14.0%), coagulase-negative staphylococci (CoNS) (12.6%), Klebsiella spp. (12.0%), and Acinetobacter spp. (11.4%). the crude mortality was 40.0%. Forty-nine percent of nBSIs occurred in the intensive-care unit (ICU). the most frequent underlying conditions were malignancy, in 622 patients (24.3%). Among the potential factors predisposing patients to BSI, central venous catheters were the most frequent (70.3%). Methicillin resistance was detected in 157 S. aureus isolates (43.7%). of the Klebsiella sp. isolates, 54.9% were resistant to third-generation cephalosporins. of the Acinetobacter spp. and Pseudomonas aeruginosa isolates, 55.9% and 36.8%, respectively, were resistant to imipenem. in our multicenter study, we found high crude mortality and a high proportion of nBSIs due to antibiotic-resistant organisms. |
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Marra, Alexandre Rodrigues [UNIFESP]Camargo, Luis Fernando Aranha [UNIFESP]Pignatari, Antonio Carlos Campos [UNIFESP]Sukiennik, Teresa Cristina TeixeiraBehar, Paulo Renato PetersenMedeiros, Eduardo Alexandrino Servolo de [UNIFESP]Ribeiro, JulivalGirao, EvelyneCorrea, LuciGuerra, Carla MoralesBrites, CarlosPereira, Carlos Alberto Pires [UNIFESP]Carneiro, Irna Carla do Rosario SouzaReis, MariseSouza, Marta Antunes deTranchesi, Regina Aparecida de MedeirosBarata, Cristina U.Edmond, Michael B.Brazilian SCOPE Study GrpHosp Israelita Albert EinsteinUniversidade Federal de São Paulo (UNIFESP)Hosp 9 JulhoHosp ConceicaoHosp BaseHosp Walter CantidioHosp DiademaInst Oncol Pediat IOP GRAACHosp EspanholHosp CoracaoHosp UNIMEDHosp Clin GoianiaHosp Rim & HypertensaoUniv Fed Triangulo MineiroVirginia Commonwealth Univ2016-01-24T14:16:40Z2016-01-24T14:16:40Z2011-05-01Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality. Data from a nationwide, concurrent surveillance study, Brazilian SCOPE (Surveillance and Control of Pathogens of Epidemiological Importance), were used to examine the epidemiology and microbiology of nBSIs at 16 Brazilian hospitals. in our study 2,563 patients with nBSIs were included from 12 June 2007 to 31 March 2010. Ninety-five percent of BSIs were monomicrobial. Gram-negative organisms caused 58.5% of these BSIs, Gram-positive organisms caused 35.4%, and fungi caused 6.1%. the most common pathogens (monomicrobial) were Staphylococcus aureus (14.0%), coagulase-negative staphylococci (CoNS) (12.6%), Klebsiella spp. (12.0%), and Acinetobacter spp. (11.4%). the crude mortality was 40.0%. Forty-nine percent of nBSIs occurred in the intensive-care unit (ICU). the most frequent underlying conditions were malignancy, in 622 patients (24.3%). Among the potential factors predisposing patients to BSI, central venous catheters were the most frequent (70.3%). Methicillin resistance was detected in 157 S. aureus isolates (43.7%). of the Klebsiella sp. isolates, 54.9% were resistant to third-generation cephalosporins. of the Acinetobacter spp. and Pseudomonas aeruginosa isolates, 55.9% and 36.8%, respectively, were resistant to imipenem. in our multicenter study, we found high crude mortality and a high proportion of nBSIs due to antibiotic-resistant organisms.Hosp Israelita Albert Einstein, Intens Care Unit, BR-05651901 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilHosp 9 Julho, São Paulo, BrazilHosp Conceicao, Porto Alegre, RS, BrazilHosp Base, Brasilia, DF, BrazilHosp Walter Cantidio, Fortaleza, Ceara, BrazilHosp Diadema, São Paulo, BrazilInst Oncol Pediat IOP GRAAC, São Paulo, BrazilHosp Espanhol, Salvador, BA, BrazilHosp Coracao, Natal, RN, BrazilHosp UNIMED, Natal, RN, BrazilHosp Clin Goiania, Goiania, Go, BrazilHosp Rim & Hypertensao, São Paulo, BrazilUniv Fed Triangulo Mineiro, Uberaba, MG, BrazilVirginia Commonwealth Univ, Richmond, VA USAUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilWeb of SciencePfizer, Inc.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2006/57700-01866-1871Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 49, n. 5, p. 1866-1871, 2011.10.1128/JCM.00376-11WOS000289941000025.pdf0095-1137https://repositorio.unifesp.br/handle/11600/33655https://dx.doi.org/10.1128/JCM.00376-11WOS:000289941000025engAmer Soc MicrobiologyJournal of Clinical MicrobiologyNosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000289941000025.pdfapplication/pdf70852https://repositorio.unifesp.br/bitstreams/8fc314f4-253a-486c-a614-94032b25813c/downloada14230f58caca03f08ca253f56ff2c30MD51TEXTWOS000289941000025.pdf.txtWOS000289941000025.pdf.txtExtracted texttext/plain38377https://repositorio.unifesp.br/bitstreams/ddf51cea-38e9-47a7-b48f-d6406fae52f4/downloadf25a86b324dd6bfd5a6575e334e12734MD5211600/336552024-01-25 19:37:50.46oai:repositorio.unifesp.br/:11600/33655https://repositorio.unifesp.brRepositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652024-01-25T19:37:50Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study |
title |
Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study |
spellingShingle |
Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study Marra, Alexandre Rodrigues [UNIFESP] |
title_short |
Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study |
title_full |
Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study |
title_fullStr |
Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study |
title_full_unstemmed |
Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study |
title_sort |
Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study |
author |
Marra, Alexandre Rodrigues [UNIFESP] |
author_facet |
Marra, Alexandre Rodrigues [UNIFESP] Camargo, Luis Fernando Aranha [UNIFESP] Pignatari, Antonio Carlos Campos [UNIFESP] Sukiennik, Teresa Cristina Teixeira Behar, Paulo Renato Petersen Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] Ribeiro, Julival Girao, Evelyne Correa, Luci Guerra, Carla Morales Brites, Carlos Pereira, Carlos Alberto Pires [UNIFESP] Carneiro, Irna Carla do Rosario Souza Reis, Marise Souza, Marta Antunes de Tranchesi, Regina Aparecida de Medeiros Barata, Cristina U. Edmond, Michael B. Brazilian SCOPE Study Grp |
author_role |
author |
author2 |
Camargo, Luis Fernando Aranha [UNIFESP] Pignatari, Antonio Carlos Campos [UNIFESP] Sukiennik, Teresa Cristina Teixeira Behar, Paulo Renato Petersen Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] Ribeiro, Julival Girao, Evelyne Correa, Luci Guerra, Carla Morales Brites, Carlos Pereira, Carlos Alberto Pires [UNIFESP] Carneiro, Irna Carla do Rosario Souza Reis, Marise Souza, Marta Antunes de Tranchesi, Regina Aparecida de Medeiros Barata, Cristina U. Edmond, Michael B. Brazilian SCOPE Study Grp |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Hosp Israelita Albert Einstein Universidade Federal de São Paulo (UNIFESP) Hosp 9 Julho Hosp Conceicao Hosp Base Hosp Walter Cantidio Hosp Diadema Inst Oncol Pediat IOP GRAAC Hosp Espanhol Hosp Coracao Hosp UNIMED Hosp Clin Goiania Hosp Rim & Hypertensao Univ Fed Triangulo Mineiro Virginia Commonwealth Univ |
dc.contributor.author.fl_str_mv |
Marra, Alexandre Rodrigues [UNIFESP] Camargo, Luis Fernando Aranha [UNIFESP] Pignatari, Antonio Carlos Campos [UNIFESP] Sukiennik, Teresa Cristina Teixeira Behar, Paulo Renato Petersen Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] Ribeiro, Julival Girao, Evelyne Correa, Luci Guerra, Carla Morales Brites, Carlos Pereira, Carlos Alberto Pires [UNIFESP] Carneiro, Irna Carla do Rosario Souza Reis, Marise Souza, Marta Antunes de Tranchesi, Regina Aparecida de Medeiros Barata, Cristina U. Edmond, Michael B. Brazilian SCOPE Study Grp |
description |
Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality. Data from a nationwide, concurrent surveillance study, Brazilian SCOPE (Surveillance and Control of Pathogens of Epidemiological Importance), were used to examine the epidemiology and microbiology of nBSIs at 16 Brazilian hospitals. in our study 2,563 patients with nBSIs were included from 12 June 2007 to 31 March 2010. Ninety-five percent of BSIs were monomicrobial. Gram-negative organisms caused 58.5% of these BSIs, Gram-positive organisms caused 35.4%, and fungi caused 6.1%. the most common pathogens (monomicrobial) were Staphylococcus aureus (14.0%), coagulase-negative staphylococci (CoNS) (12.6%), Klebsiella spp. (12.0%), and Acinetobacter spp. (11.4%). the crude mortality was 40.0%. Forty-nine percent of nBSIs occurred in the intensive-care unit (ICU). the most frequent underlying conditions were malignancy, in 622 patients (24.3%). Among the potential factors predisposing patients to BSI, central venous catheters were the most frequent (70.3%). Methicillin resistance was detected in 157 S. aureus isolates (43.7%). of the Klebsiella sp. isolates, 54.9% were resistant to third-generation cephalosporins. of the Acinetobacter spp. and Pseudomonas aeruginosa isolates, 55.9% and 36.8%, respectively, were resistant to imipenem. in our multicenter study, we found high crude mortality and a high proportion of nBSIs due to antibiotic-resistant organisms. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-05-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:16:40Z |
dc.date.available.fl_str_mv |
2016-01-24T14:16:40Z |
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info:eu-repo/semantics/publishedVersion |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 49, n. 5, p. 1866-1871, 2011. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/33655 https://dx.doi.org/10.1128/JCM.00376-11 |
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10.1128/JCM.00376-11 |
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WOS000289941000025.pdf |
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0095-1137 |
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WOS:000289941000025 |
identifier_str_mv |
Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 49, n. 5, p. 1866-1871, 2011. 10.1128/JCM.00376-11 WOS000289941000025.pdf 0095-1137 WOS:000289941000025 |
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https://repositorio.unifesp.br/handle/11600/33655 https://dx.doi.org/10.1128/JCM.00376-11 |
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1866-1871 |
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Amer Soc Microbiology |
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Amer Soc Microbiology |
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