Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina

Detalhes bibliográficos
Autor(a) principal: Martins, Jefferson Silva [UNIFESP]
Data de Publicação: 2019
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=7656613
https://repositorio.unifesp.br/handle/11600/59372
Resumo: Introduction: Oxaliplatin is one of main drugs used in the treatment of gastrointestinal cancers. Peripheral neuropathy is the greatest adverse reaction, which, depending on its degree, may limit the patient’s quality of life. Objectives: To evaluate the incidence of clinical neurotoxicity due to the chemotherapy and electrolyte dosage in saliva of patients with gastrointestinal cancer submitted to oxaliplatin. Methods: We included cancer patients using oxaliplatin from UNIFESP’s oncology center and volunteers without cancer who never used oxaliplatin. The oxaliplatin toxicity assessment questionnaire (QATIO) adapted from the Common Terminology Criteria for Adverse Events toxicity questionnaire was applied. The saliva was collected by the method of voluntary spitting in a universal collector for 5 minutes. After collection, the saliva samples were stored at -80° C. The dosages of sodium, potassium, chlorum, magnesium, phosphorus and calcium were determined. Statistical analysis: Exploratory data analysis included mean, median, standard deviation and variation for continuous variables and number and proportion for categorical variables. Comparison of continuous variables between independent groups was performed by the Mann-Whitney test, and categorical variables using Pearson's chi-square test or Fisher's exact test, when appropriate. Comparison of electrolytes over time was performed by the Friedman test. All tests were two-tailed and values of P <0.05 were considered significant. Results: We included 17 cancer patients and 46 controls. The cumulative oxaliplatin dose range was 77 mg / m² to 2906 mg / m². In the cancer group, questionnaires and saliva collection were performed 1-4 times, totalizing 43 QATIOs and the same number of saliva samples was collected. Through the application of QATIO it was possible to identify neuropathy in cancer patients, as well as the simplification of the questionnaire from 13 to 7 questions to be used by health professionals. Increased oxaliplatin neurotoxicity corresponded to increased exposure to oxaliplatin. Conclusion: In this study, it was possible to analyze the peripheral neuropathy associated with the use of oxaliplatin through the application of QATIO. We obtained 7 from a total of 13 questions with statistical significance in relation to the control. Therefore, we suggest the application of QATIO in the determination of oxaliplatin induced peripheral neuropathy.
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spelling Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatinaEvaluation of clinical neurotoxicity and biochemical changes in saliva of patients in oxaliplatin useSalivaOxaliplatinToxicityBiochemistryCancerPeripheral Neurotoxicity Induced By OxaliplatinSalivaOxaliplatinaToxicidadeBioquímicaCâncerNeurotoxicidade Periférica Induzida Por OxaliplatinaIntroduction: Oxaliplatin is one of main drugs used in the treatment of gastrointestinal cancers. Peripheral neuropathy is the greatest adverse reaction, which, depending on its degree, may limit the patient’s quality of life. Objectives: To evaluate the incidence of clinical neurotoxicity due to the chemotherapy and electrolyte dosage in saliva of patients with gastrointestinal cancer submitted to oxaliplatin. Methods: We included cancer patients using oxaliplatin from UNIFESP’s oncology center and volunteers without cancer who never used oxaliplatin. The oxaliplatin toxicity assessment questionnaire (QATIO) adapted from the Common Terminology Criteria for Adverse Events toxicity questionnaire was applied. The saliva was collected by the method of voluntary spitting in a universal collector for 5 minutes. After collection, the saliva samples were stored at -80° C. The dosages of sodium, potassium, chlorum, magnesium, phosphorus and calcium were determined. Statistical analysis: Exploratory data analysis included mean, median, standard deviation and variation for continuous variables and number and proportion for categorical variables. Comparison of continuous variables between independent groups was performed by the Mann-Whitney test, and categorical variables using Pearson's chi-square test or Fisher's exact test, when appropriate. Comparison of electrolytes over time was performed by the Friedman test. All tests were two-tailed and values of P <0.05 were considered significant. Results: We included 17 cancer patients and 46 controls. The cumulative oxaliplatin dose range was 77 mg / m² to 2906 mg / m². In the cancer group, questionnaires and saliva collection were performed 1-4 times, totalizing 43 QATIOs and the same number of saliva samples was collected. Through the application of QATIO it was possible to identify neuropathy in cancer patients, as well as the simplification of the questionnaire from 13 to 7 questions to be used by health professionals. Increased oxaliplatin neurotoxicity corresponded to increased exposure to oxaliplatin. Conclusion: In this study, it was possible to analyze the peripheral neuropathy associated with the use of oxaliplatin through the application of QATIO. We obtained 7 from a total of 13 questions with statistical significance in relation to the control. Therefore, we suggest the application of QATIO in the determination of oxaliplatin induced peripheral neuropathy.Introdução A oxaliplatina compõe o arsenal terapêutico no tratamento dos cânceres gastrintestinais. A neuropatia periférica, que pode limitar a qualidade de vida do indivíduo e alteração do paladar que pode ocorrer durante a quimioterapia são uma das principais reações adversas. Objetivo: Avaliar a incidência de neurotoxicidade clínica e dosagem de eletrólitos em saliva de pacientes com câncer gastrintestinal submetidos a oxaliplatina. Método: Participaram do estudo pacientes com câncer em uso de oxaliplatina e voluntários sem câncer. Foi aplicado o questionário de avaliação de toxicidade induzida por oxaliplatina (QATIO), adaptado do questionário de toxicidade “Common Terminology Criteria for Adverse Events”. A saliva foi coletada pelo método de cusparadas voluntárias em coletor universal pelo tempo de 5 minutos. Após coleta, as amostras de saliva foram armazenadas a -80°C para posterior dosagem de sódio, potássio, cloro, magnésio, fosforo e cálcio. Análise estatística: A análise exploratória dos dados incluiu média, mediana, desvio-padrão e variação para variáveis contínuas e número e proporção para variáveis categóricas. A distribuição normal das variáveis contínuas foi verificada pela assimetria, curtose e teste de Kolmogorov-Smirnov. Comparação de variáveis contínuas entre grupos independentes foi realizada pelo teste de Mann-Whitney, e de variáveis categóricas pelo teste qui-quadrado de Pearson ou exato de Fisher, quando apropriado. Comparação dos eletrólitos ao longo do tempo (amostras dependentes) foi realizada pelo teste de Friedman. Todos os testes foram bicaudais e valores de P < 0,05 foram considerados significantes. Resultados: Foram incluídos 17 pacientes com câncer e 46 controles. O intervalo de dose cumulativa de oxaliplatina foi de 77mg/m² a 2906 mg/m². No grupo câncer, os questionários e a coleta de saliva foram realizadas de 1-4 vezes totalizando 43 QATIOs e o mesmo número de amostras de saliva coletadas. Por meio da aplicação do QATIO foi possível identificar neuropatia nos pacientes com câncer, bem como a simplificação do questionário de 13 para 7 perguntas a serem utilizadas pelos profissionais de saúde. Podemos observar aumento na incidência dos principais sinais e sintomas relacionadas a neurotoxicidade por oxaliplatina de acordo com o aumento de exposição a oxaliplatina. Conclusão: Neste trabalho, foi possível analisar o grau de neuropatia periférica associado ao uso de oxaliplatina por meio da aplicação do QATIO. Obtivemos 7 de um total de 13 perguntas com diferença estatisticamente significativa em relação ao controle. Sendo assim sugere-se aplicação do QATIO simplificado na determinação de neuropatia induzida pelo uso de oxaliplatina.Dados abertos - Sucupira - Teses e dissertações (2019)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo (UNIFESP)Forones, Nora Manoukian [UNIFESP]http://lattes.cnpq.br/7314943504526739http://lattes.cnpq.br/6693360538418804Universidade Federal de São Paulo (UNIFESP)Martins, Jefferson Silva [UNIFESP]2021-01-19T16:32:14Z2021-01-19T16:32:14Z2019-05-30info:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/publishedVersion86 p.application/pdfhttps://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=7656613MARTINS, Jefferson Silva. Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina. 2019. 61f. Dissertação (Mestrado em Medicina Translacional) – Escola Paulista de Medicina, Universidade Federal de São Paulo. São Paulo, 2019.Jefferson Silva Martins -A.pdfhttps://repositorio.unifesp.br/handle/11600/59372porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T01:04:27Zoai:repositorio.unifesp.br/:11600/59372Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T01:04:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina
Evaluation of clinical neurotoxicity and biochemical changes in saliva of patients in oxaliplatin use
title Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina
spellingShingle Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina
Martins, Jefferson Silva [UNIFESP]
Saliva
Oxaliplatin
Toxicity
Biochemistry
Cancer
Peripheral Neurotoxicity Induced By Oxaliplatin
Saliva
Oxaliplatina
Toxicidade
Bioquímica
Câncer
Neurotoxicidade Periférica Induzida Por Oxaliplatina
title_short Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina
title_full Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina
title_fullStr Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina
title_full_unstemmed Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina
title_sort Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina
author Martins, Jefferson Silva [UNIFESP]
author_facet Martins, Jefferson Silva [UNIFESP]
author_role author
dc.contributor.none.fl_str_mv Forones, Nora Manoukian [UNIFESP]
http://lattes.cnpq.br/7314943504526739
http://lattes.cnpq.br/6693360538418804
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Martins, Jefferson Silva [UNIFESP]
dc.subject.por.fl_str_mv Saliva
Oxaliplatin
Toxicity
Biochemistry
Cancer
Peripheral Neurotoxicity Induced By Oxaliplatin
Saliva
Oxaliplatina
Toxicidade
Bioquímica
Câncer
Neurotoxicidade Periférica Induzida Por Oxaliplatina
topic Saliva
Oxaliplatin
Toxicity
Biochemistry
Cancer
Peripheral Neurotoxicity Induced By Oxaliplatin
Saliva
Oxaliplatina
Toxicidade
Bioquímica
Câncer
Neurotoxicidade Periférica Induzida Por Oxaliplatina
description Introduction: Oxaliplatin is one of main drugs used in the treatment of gastrointestinal cancers. Peripheral neuropathy is the greatest adverse reaction, which, depending on its degree, may limit the patient’s quality of life. Objectives: To evaluate the incidence of clinical neurotoxicity due to the chemotherapy and electrolyte dosage in saliva of patients with gastrointestinal cancer submitted to oxaliplatin. Methods: We included cancer patients using oxaliplatin from UNIFESP’s oncology center and volunteers without cancer who never used oxaliplatin. The oxaliplatin toxicity assessment questionnaire (QATIO) adapted from the Common Terminology Criteria for Adverse Events toxicity questionnaire was applied. The saliva was collected by the method of voluntary spitting in a universal collector for 5 minutes. After collection, the saliva samples were stored at -80° C. The dosages of sodium, potassium, chlorum, magnesium, phosphorus and calcium were determined. Statistical analysis: Exploratory data analysis included mean, median, standard deviation and variation for continuous variables and number and proportion for categorical variables. Comparison of continuous variables between independent groups was performed by the Mann-Whitney test, and categorical variables using Pearson's chi-square test or Fisher's exact test, when appropriate. Comparison of electrolytes over time was performed by the Friedman test. All tests were two-tailed and values of P <0.05 were considered significant. Results: We included 17 cancer patients and 46 controls. The cumulative oxaliplatin dose range was 77 mg / m² to 2906 mg / m². In the cancer group, questionnaires and saliva collection were performed 1-4 times, totalizing 43 QATIOs and the same number of saliva samples was collected. Through the application of QATIO it was possible to identify neuropathy in cancer patients, as well as the simplification of the questionnaire from 13 to 7 questions to be used by health professionals. Increased oxaliplatin neurotoxicity corresponded to increased exposure to oxaliplatin. Conclusion: In this study, it was possible to analyze the peripheral neuropathy associated with the use of oxaliplatin through the application of QATIO. We obtained 7 from a total of 13 questions with statistical significance in relation to the control. Therefore, we suggest the application of QATIO in the determination of oxaliplatin induced peripheral neuropathy.
publishDate 2019
dc.date.none.fl_str_mv 2019-05-30
2021-01-19T16:32:14Z
2021-01-19T16:32:14Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=7656613
MARTINS, Jefferson Silva. Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina. 2019. 61f. Dissertação (Mestrado em Medicina Translacional) – Escola Paulista de Medicina, Universidade Federal de São Paulo. São Paulo, 2019.
Jefferson Silva Martins -A.pdf
https://repositorio.unifesp.br/handle/11600/59372
url https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=7656613
https://repositorio.unifesp.br/handle/11600/59372
identifier_str_mv MARTINS, Jefferson Silva. Avaliação de neurotoxicidade clínica e alterações bioquímicas em saliva de pacientes em uso de oxaliplatina. 2019. 61f. Dissertação (Mestrado em Medicina Translacional) – Escola Paulista de Medicina, Universidade Federal de São Paulo. São Paulo, 2019.
Jefferson Silva Martins -A.pdf
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 86 p.
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
publisher.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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