Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S0004-282X2012000500003 http://repositorio.unifesp.br/handle/11600/7091 |
Resumo: | OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS. |
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Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcomeEpilepsia do lobo temporal com esclerose mesial temporal: o padrão da perda neuronal hipocampal como preditor do prognóstico cirúrgicoepilepsytemporal lobemesial temporal sclerosishippocampal sclerosispathologysurgical prognosisepilepsia do lobo temporalesclerose mesial temporalesclerose hipocampalpatologiaprognóstico cirúrgicoOBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS.OBJETIVO: Analisar retrospectivamente uma série de pacientes com epilepsia do lobo temporal (ELT) e esclerose mesial temporal (EMT), bem como correlacionar os padrões de esclerose hipocampal com os dados clínicos e o prognóstico cirúrgico. MÉTODOS: Foram incluídos neste estudo 66 pacientes com ELT refratária a tratamento medicamentoso e com EMT unilateral submetidos à lobectomia temporal anterior. A análise neuropatológica quantitativa foi realizada em seções hipocampais imunomarcadas com NeuN. Dados clínicos e resultados do acompanhamento pós-cirúrgico foram revisados. RESULTADOS: Ocorrência de evento precipitante inicial e melhor controle de crises após a cirurgia (i.e. classe 1 de Engel) foram associados aos padrões clássico (EMT tipo 1a) e severo (EMT tipo 1b) de esclerose hipocampal. CONCLUSÃO: A análise quantitativa do padrão de perda neuronal do hipocampo é capaz de predizer o prognóstico cirúrgico em pacientes com ELT-EMT.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of Neurology and NeurosurgerySanta Casa de São Paulo Department of PathologyAssociação Fundo de Incentivo à Pesquisa Department of Pathology, Medical DiagnosisUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Department of Neurology and Neuroscience, Experimental NeurologyUNIFESP, EPM, Department of Neurology and NeurosurgeryUNIFESP, EPM, Department of Neurology and Neuroscience, Experimental NeurologySciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Academia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Santa Casa de São Paulo Department of PathologyAssociação Fundo de Incentivo à Pesquisa Department of Pathology, Medical DiagnosisJardim, Anaclara Prada [UNIFESP]Neves, Rafael Scarpa da Costa [UNIFESP]Caboclo, Luís Otávio Sales Ferreira [UNIFESP]Lancellotti, Carmen Lucia PenteadoMarinho, Murilo Martinez [UNIFESP]Centeno, Ricardo Silva [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]Scorza, Carla Alessandra [UNIFESP]Yacubian, Elza Márcia Targas [UNIFESP]2015-06-14T13:43:44Z2015-06-14T13:43:44Z2012-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion319-324application/pdfhttp://dx.doi.org/10.1590/S0004-282X2012000500003Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 70, n. 5, p. 319-324, 2012.10.1590/S0004-282X2012000500003S0004-282X2012000500003.pdf0004-282XS0004-282X2012000500003http://repositorio.unifesp.br/handle/11600/7091WOS:000304362100003engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T20:00:43Zoai:repositorio.unifesp.br/:11600/7091Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T20:00:43Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome Epilepsia do lobo temporal com esclerose mesial temporal: o padrão da perda neuronal hipocampal como preditor do prognóstico cirúrgico |
| title |
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome |
| spellingShingle |
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome Jardim, Anaclara Prada [UNIFESP] epilepsy temporal lobe mesial temporal sclerosis hippocampal sclerosis pathology surgical prognosis epilepsia do lobo temporal esclerose mesial temporal esclerose hipocampal patologia prognóstico cirúrgico |
| title_short |
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome |
| title_full |
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome |
| title_fullStr |
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome |
| title_full_unstemmed |
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome |
| title_sort |
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome |
| author |
Jardim, Anaclara Prada [UNIFESP] |
| author_facet |
Jardim, Anaclara Prada [UNIFESP] Neves, Rafael Scarpa da Costa [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Lancellotti, Carmen Lucia Penteado Marinho, Murilo Martinez [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Scorza, Carla Alessandra [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
| author_role |
author |
| author2 |
Neves, Rafael Scarpa da Costa [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Lancellotti, Carmen Lucia Penteado Marinho, Murilo Martinez [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Scorza, Carla Alessandra [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Santa Casa de São Paulo Department of Pathology Associação Fundo de Incentivo à Pesquisa Department of Pathology, Medical Diagnosis |
| dc.contributor.author.fl_str_mv |
Jardim, Anaclara Prada [UNIFESP] Neves, Rafael Scarpa da Costa [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Lancellotti, Carmen Lucia Penteado Marinho, Murilo Martinez [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Scorza, Carla Alessandra [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
| dc.subject.por.fl_str_mv |
epilepsy temporal lobe mesial temporal sclerosis hippocampal sclerosis pathology surgical prognosis epilepsia do lobo temporal esclerose mesial temporal esclerose hipocampal patologia prognóstico cirúrgico |
| topic |
epilepsy temporal lobe mesial temporal sclerosis hippocampal sclerosis pathology surgical prognosis epilepsia do lobo temporal esclerose mesial temporal esclerose hipocampal patologia prognóstico cirúrgico |
| description |
OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-05-01 2015-06-14T13:43:44Z 2015-06-14T13:43:44Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-282X2012000500003 Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 70, n. 5, p. 319-324, 2012. 10.1590/S0004-282X2012000500003 S0004-282X2012000500003.pdf 0004-282X S0004-282X2012000500003 http://repositorio.unifesp.br/handle/11600/7091 WOS:000304362100003 |
| url |
http://dx.doi.org/10.1590/S0004-282X2012000500003 http://repositorio.unifesp.br/handle/11600/7091 |
| identifier_str_mv |
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 70, n. 5, p. 319-324, 2012. 10.1590/S0004-282X2012000500003 S0004-282X2012000500003.pdf 0004-282X S0004-282X2012000500003 WOS:000304362100003 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
319-324 application/pdf |
| dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
| publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268451269640192 |