Porcine pericardium as glaucoma implant tube coverage: an experimental study

Detalhes bibliográficos
Autor(a) principal: Pinto, Luciano Moreira [UNIFESP]
Data de Publicação: 2008
Outros Autores: Regatieri, Caio Vinicius Saito [UNIFESP], Tavares, Ivan Maynart [UNIFESP], Rigueiro, Moacyr Pezati [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27492008000500003
http://repositorio.unifesp.br/handle/11600/4592
Resumo: PURPOSE: To evaluate the inflammatory response associated with the use of processed porcine pericardium and glycerin-preserved homologous sclera as silicone glaucoma drainage device coverage in a rabbit experimental model. METHODS: Eight New Zealand white rabbits' eyes received an equal-sized glycerin-preserved homologous scleral patch or a double-layered processed porcine pericardium that was sutured to the bare sclera covering a silicone tube. Conjunctival hyperemia was graded using the double-blind method during the immediate postoperative period and during the first, third, and seventh postoperative weeks. After the seventh week, the enucleated eyes were histopathologically examined. They were also evaluated for signs of patch graft melting, tube erosion and chemosis. RESULTS: There was no occurrence of graft melting or tube exposure, although porcine pericardium was associated with greater inflammation through clinical observation. Light microscopy revealed marked inflammation surrounding the porcine pericardium with foreign body granuloma formation. On the other hand, the sclera group presented milder inflammation with foreign body granulomas only around the sutures. CONCLUSIONS: Porcine pericardium is associated with significant inflammation when used as tube coverage in a rabbit model, at both histopathologic and clinical levels, when compared to glycerin-preserved homologous sclera during the seven-week follow-up period.
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spelling Porcine pericardium as glaucoma implant tube coverage: an experimental studyUso de pericárdio suíno no recobrimento de implantes de drenagem de glaucoma: um estudo experimentalTransplantation, heterologousPericardiumGlaucoma drainage implantsGlaucomaSwineTransplante heterólogoPericárdioImplantes para drenagem de glaucomaGlaucomaSuínosPURPOSE: To evaluate the inflammatory response associated with the use of processed porcine pericardium and glycerin-preserved homologous sclera as silicone glaucoma drainage device coverage in a rabbit experimental model. METHODS: Eight New Zealand white rabbits' eyes received an equal-sized glycerin-preserved homologous scleral patch or a double-layered processed porcine pericardium that was sutured to the bare sclera covering a silicone tube. Conjunctival hyperemia was graded using the double-blind method during the immediate postoperative period and during the first, third, and seventh postoperative weeks. After the seventh week, the enucleated eyes were histopathologically examined. They were also evaluated for signs of patch graft melting, tube erosion and chemosis. RESULTS: There was no occurrence of graft melting or tube exposure, although porcine pericardium was associated with greater inflammation through clinical observation. Light microscopy revealed marked inflammation surrounding the porcine pericardium with foreign body granuloma formation. On the other hand, the sclera group presented milder inflammation with foreign body granulomas only around the sutures. CONCLUSIONS: Porcine pericardium is associated with significant inflammation when used as tube coverage in a rabbit model, at both histopathologic and clinical levels, when compared to glycerin-preserved homologous sclera during the seven-week follow-up period.OBJETIVO: Avaliar a resposta inflamatória associada com o uso de pericárdio suíno processado e esclera homóloga preservada em glicerina no recobrimento de tubo de drenagem de silicone utilizado em cirurgia de glaucoma em modelo experimental. MÉTODOS: Oito olhos de 8 coelhos albinos da raça Nova Zelândia receberam enxertos do mesmo tamanho de esclera homóloga, preservada em glicerina ou pericárdio suíno processado, suturados à esclera recobrindo um tubo de silicone. Os olhos foram avaliados quanto à hiperemia conjuntival de modo mascarado na primeira, terceira e sétima semanas de pós-operatório. Após a sétima semana os olhos foram enucleados e submetidos a estudo histopatológico. Os olhos também foram avaliados quanto à presença de afinamento do enxerto, exposição do tubo e quemose. RESULTADOS: Não ocorreram casos de afinamento do enxerto ou exposição do tubo, porém o pericárdio suíno esteve associado clinicamente a uma maior inflamação. Achados à microscopia óptica incluíram intensa reação inflamatória em torno do enxerto de pericárdio com formação de granuloma do tipo corpo estranho. Por outro lado, no grupo que recebeu esclera, ocorreu formação de granulomas apenas em torno dos fios de sutura. CONCLUSÃO: O pericárdio suíno esteve associado a maior inflamação tanto à histopatologia quanto clinicamente, quando usado no recobrimento de tubo de silicone, em comparação à esclera homóloga preservada em glicerina, durante o período de acompanhamento de sete semanas.Universidade Federal de São Paulo (UNIFESP) - UNIFESP Departamento de OftalmologiaUNIFESP Departamento de OftalmologiaUNIFESP Departamento de Oftalmologia Setor de GlaucomaUNIFESP Departamento de PatologiaUNIFESP, Depto. de OftalmologiaUNIFESP, Depto. de OftalmologiaUNIFESP, Depto. de Oftalmologia Setor de GlaucomaUNIFESP, Depto. de PatologiaSciELOConselho Brasileiro de OftalmologiaUniversidade Federal de São Paulo (UNIFESP)Pinto, Luciano Moreira [UNIFESP]Regatieri, Caio Vinicius Saito [UNIFESP]Tavares, Ivan Maynart [UNIFESP]Rigueiro, Moacyr Pezati [UNIFESP]2015-06-14T13:38:46Z2015-06-14T13:38:46Z2008-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion623-628application/pdfhttp://dx.doi.org/10.1590/S0004-27492008000500003Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 71, n. 5, p. 623-628, 2008.10.1590/S0004-27492008000500003S0004-27492008000500003.pdf0004-2749S0004-27492008000500003http://repositorio.unifesp.br/handle/11600/4592engArquivos Brasileiros de Oftalmologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T20:47:25Zoai:repositorio.unifesp.br/:11600/4592Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T20:47:25Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Porcine pericardium as glaucoma implant tube coverage: an experimental study
Uso de pericárdio suíno no recobrimento de implantes de drenagem de glaucoma: um estudo experimental
title Porcine pericardium as glaucoma implant tube coverage: an experimental study
spellingShingle Porcine pericardium as glaucoma implant tube coverage: an experimental study
Pinto, Luciano Moreira [UNIFESP]
Transplantation, heterologous
Pericardium
Glaucoma drainage implants
Glaucoma
Swine
Transplante heterólogo
Pericárdio
Implantes para drenagem de glaucoma
Glaucoma
Suínos
title_short Porcine pericardium as glaucoma implant tube coverage: an experimental study
title_full Porcine pericardium as glaucoma implant tube coverage: an experimental study
title_fullStr Porcine pericardium as glaucoma implant tube coverage: an experimental study
title_full_unstemmed Porcine pericardium as glaucoma implant tube coverage: an experimental study
title_sort Porcine pericardium as glaucoma implant tube coverage: an experimental study
author Pinto, Luciano Moreira [UNIFESP]
author_facet Pinto, Luciano Moreira [UNIFESP]
Regatieri, Caio Vinicius Saito [UNIFESP]
Tavares, Ivan Maynart [UNIFESP]
Rigueiro, Moacyr Pezati [UNIFESP]
author_role author
author2 Regatieri, Caio Vinicius Saito [UNIFESP]
Tavares, Ivan Maynart [UNIFESP]
Rigueiro, Moacyr Pezati [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Pinto, Luciano Moreira [UNIFESP]
Regatieri, Caio Vinicius Saito [UNIFESP]
Tavares, Ivan Maynart [UNIFESP]
Rigueiro, Moacyr Pezati [UNIFESP]
dc.subject.por.fl_str_mv Transplantation, heterologous
Pericardium
Glaucoma drainage implants
Glaucoma
Swine
Transplante heterólogo
Pericárdio
Implantes para drenagem de glaucoma
Glaucoma
Suínos
topic Transplantation, heterologous
Pericardium
Glaucoma drainage implants
Glaucoma
Swine
Transplante heterólogo
Pericárdio
Implantes para drenagem de glaucoma
Glaucoma
Suínos
description PURPOSE: To evaluate the inflammatory response associated with the use of processed porcine pericardium and glycerin-preserved homologous sclera as silicone glaucoma drainage device coverage in a rabbit experimental model. METHODS: Eight New Zealand white rabbits' eyes received an equal-sized glycerin-preserved homologous scleral patch or a double-layered processed porcine pericardium that was sutured to the bare sclera covering a silicone tube. Conjunctival hyperemia was graded using the double-blind method during the immediate postoperative period and during the first, third, and seventh postoperative weeks. After the seventh week, the enucleated eyes were histopathologically examined. They were also evaluated for signs of patch graft melting, tube erosion and chemosis. RESULTS: There was no occurrence of graft melting or tube exposure, although porcine pericardium was associated with greater inflammation through clinical observation. Light microscopy revealed marked inflammation surrounding the porcine pericardium with foreign body granuloma formation. On the other hand, the sclera group presented milder inflammation with foreign body granulomas only around the sutures. CONCLUSIONS: Porcine pericardium is associated with significant inflammation when used as tube coverage in a rabbit model, at both histopathologic and clinical levels, when compared to glycerin-preserved homologous sclera during the seven-week follow-up period.
publishDate 2008
dc.date.none.fl_str_mv 2008-10-01
2015-06-14T13:38:46Z
2015-06-14T13:38:46Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27492008000500003
Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 71, n. 5, p. 623-628, 2008.
10.1590/S0004-27492008000500003
S0004-27492008000500003.pdf
0004-2749
S0004-27492008000500003
http://repositorio.unifesp.br/handle/11600/4592
url http://dx.doi.org/10.1590/S0004-27492008000500003
http://repositorio.unifesp.br/handle/11600/4592
identifier_str_mv Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 71, n. 5, p. 623-628, 2008.
10.1590/S0004-27492008000500003
S0004-27492008000500003.pdf
0004-2749
S0004-27492008000500003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Oftalmologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 623-628
application/pdf
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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