Porcine pericardium as glaucoma implant tube coverage: an experimental study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0004-27492008000500003 http://repositorio.unifesp.br/handle/11600/4592 |
Resumo: | PURPOSE: To evaluate the inflammatory response associated with the use of processed porcine pericardium and glycerin-preserved homologous sclera as silicone glaucoma drainage device coverage in a rabbit experimental model. METHODS: Eight New Zealand white rabbits' eyes received an equal-sized glycerin-preserved homologous scleral patch or a double-layered processed porcine pericardium that was sutured to the bare sclera covering a silicone tube. Conjunctival hyperemia was graded using the double-blind method during the immediate postoperative period and during the first, third, and seventh postoperative weeks. After the seventh week, the enucleated eyes were histopathologically examined. They were also evaluated for signs of patch graft melting, tube erosion and chemosis. RESULTS: There was no occurrence of graft melting or tube exposure, although porcine pericardium was associated with greater inflammation through clinical observation. Light microscopy revealed marked inflammation surrounding the porcine pericardium with foreign body granuloma formation. On the other hand, the sclera group presented milder inflammation with foreign body granulomas only around the sutures. CONCLUSIONS: Porcine pericardium is associated with significant inflammation when used as tube coverage in a rabbit model, at both histopathologic and clinical levels, when compared to glycerin-preserved homologous sclera during the seven-week follow-up period. |
id |
UFSP_8031d86be7af3fb4db9db783c8c0a59c |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/4592 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Porcine pericardium as glaucoma implant tube coverage: an experimental studyUso de pericárdio suíno no recobrimento de implantes de drenagem de glaucoma: um estudo experimentalTransplantation, heterologousPericardiumGlaucoma drainage implantsGlaucomaSwineTransplante heterólogoPericárdioImplantes para drenagem de glaucomaGlaucomaSuínosPURPOSE: To evaluate the inflammatory response associated with the use of processed porcine pericardium and glycerin-preserved homologous sclera as silicone glaucoma drainage device coverage in a rabbit experimental model. METHODS: Eight New Zealand white rabbits' eyes received an equal-sized glycerin-preserved homologous scleral patch or a double-layered processed porcine pericardium that was sutured to the bare sclera covering a silicone tube. Conjunctival hyperemia was graded using the double-blind method during the immediate postoperative period and during the first, third, and seventh postoperative weeks. After the seventh week, the enucleated eyes were histopathologically examined. They were also evaluated for signs of patch graft melting, tube erosion and chemosis. RESULTS: There was no occurrence of graft melting or tube exposure, although porcine pericardium was associated with greater inflammation through clinical observation. Light microscopy revealed marked inflammation surrounding the porcine pericardium with foreign body granuloma formation. On the other hand, the sclera group presented milder inflammation with foreign body granulomas only around the sutures. CONCLUSIONS: Porcine pericardium is associated with significant inflammation when used as tube coverage in a rabbit model, at both histopathologic and clinical levels, when compared to glycerin-preserved homologous sclera during the seven-week follow-up period.OBJETIVO: Avaliar a resposta inflamatória associada com o uso de pericárdio suíno processado e esclera homóloga preservada em glicerina no recobrimento de tubo de drenagem de silicone utilizado em cirurgia de glaucoma em modelo experimental. MÉTODOS: Oito olhos de 8 coelhos albinos da raça Nova Zelândia receberam enxertos do mesmo tamanho de esclera homóloga, preservada em glicerina ou pericárdio suíno processado, suturados à esclera recobrindo um tubo de silicone. Os olhos foram avaliados quanto à hiperemia conjuntival de modo mascarado na primeira, terceira e sétima semanas de pós-operatório. Após a sétima semana os olhos foram enucleados e submetidos a estudo histopatológico. Os olhos também foram avaliados quanto à presença de afinamento do enxerto, exposição do tubo e quemose. RESULTADOS: Não ocorreram casos de afinamento do enxerto ou exposição do tubo, porém o pericárdio suíno esteve associado clinicamente a uma maior inflamação. Achados à microscopia óptica incluíram intensa reação inflamatória em torno do enxerto de pericárdio com formação de granuloma do tipo corpo estranho. Por outro lado, no grupo que recebeu esclera, ocorreu formação de granulomas apenas em torno dos fios de sutura. CONCLUSÃO: O pericárdio suíno esteve associado a maior inflamação tanto à histopatologia quanto clinicamente, quando usado no recobrimento de tubo de silicone, em comparação à esclera homóloga preservada em glicerina, durante o período de acompanhamento de sete semanas.Universidade Federal de São Paulo (UNIFESP) - UNIFESP Departamento de OftalmologiaUNIFESP Departamento de OftalmologiaUNIFESP Departamento de Oftalmologia Setor de GlaucomaUNIFESP Departamento de PatologiaUNIFESP, Depto. de OftalmologiaUNIFESP, Depto. de OftalmologiaUNIFESP, Depto. de Oftalmologia Setor de GlaucomaUNIFESP, Depto. de PatologiaSciELOConselho Brasileiro de OftalmologiaUniversidade Federal de São Paulo (UNIFESP)Pinto, Luciano Moreira [UNIFESP]Regatieri, Caio Vinicius Saito [UNIFESP]Tavares, Ivan Maynart [UNIFESP]Rigueiro, Moacyr Pezati [UNIFESP]2015-06-14T13:38:46Z2015-06-14T13:38:46Z2008-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion623-628application/pdfhttp://dx.doi.org/10.1590/S0004-27492008000500003Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 71, n. 5, p. 623-628, 2008.10.1590/S0004-27492008000500003S0004-27492008000500003.pdf0004-2749S0004-27492008000500003http://repositorio.unifesp.br/handle/11600/4592engArquivos Brasileiros de Oftalmologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T20:47:25Zoai:repositorio.unifesp.br/:11600/4592Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T20:47:25Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Porcine pericardium as glaucoma implant tube coverage: an experimental study Uso de pericárdio suíno no recobrimento de implantes de drenagem de glaucoma: um estudo experimental |
title |
Porcine pericardium as glaucoma implant tube coverage: an experimental study |
spellingShingle |
Porcine pericardium as glaucoma implant tube coverage: an experimental study Pinto, Luciano Moreira [UNIFESP] Transplantation, heterologous Pericardium Glaucoma drainage implants Glaucoma Swine Transplante heterólogo Pericárdio Implantes para drenagem de glaucoma Glaucoma Suínos |
title_short |
Porcine pericardium as glaucoma implant tube coverage: an experimental study |
title_full |
Porcine pericardium as glaucoma implant tube coverage: an experimental study |
title_fullStr |
Porcine pericardium as glaucoma implant tube coverage: an experimental study |
title_full_unstemmed |
Porcine pericardium as glaucoma implant tube coverage: an experimental study |
title_sort |
Porcine pericardium as glaucoma implant tube coverage: an experimental study |
author |
Pinto, Luciano Moreira [UNIFESP] |
author_facet |
Pinto, Luciano Moreira [UNIFESP] Regatieri, Caio Vinicius Saito [UNIFESP] Tavares, Ivan Maynart [UNIFESP] Rigueiro, Moacyr Pezati [UNIFESP] |
author_role |
author |
author2 |
Regatieri, Caio Vinicius Saito [UNIFESP] Tavares, Ivan Maynart [UNIFESP] Rigueiro, Moacyr Pezati [UNIFESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Pinto, Luciano Moreira [UNIFESP] Regatieri, Caio Vinicius Saito [UNIFESP] Tavares, Ivan Maynart [UNIFESP] Rigueiro, Moacyr Pezati [UNIFESP] |
dc.subject.por.fl_str_mv |
Transplantation, heterologous Pericardium Glaucoma drainage implants Glaucoma Swine Transplante heterólogo Pericárdio Implantes para drenagem de glaucoma Glaucoma Suínos |
topic |
Transplantation, heterologous Pericardium Glaucoma drainage implants Glaucoma Swine Transplante heterólogo Pericárdio Implantes para drenagem de glaucoma Glaucoma Suínos |
description |
PURPOSE: To evaluate the inflammatory response associated with the use of processed porcine pericardium and glycerin-preserved homologous sclera as silicone glaucoma drainage device coverage in a rabbit experimental model. METHODS: Eight New Zealand white rabbits' eyes received an equal-sized glycerin-preserved homologous scleral patch or a double-layered processed porcine pericardium that was sutured to the bare sclera covering a silicone tube. Conjunctival hyperemia was graded using the double-blind method during the immediate postoperative period and during the first, third, and seventh postoperative weeks. After the seventh week, the enucleated eyes were histopathologically examined. They were also evaluated for signs of patch graft melting, tube erosion and chemosis. RESULTS: There was no occurrence of graft melting or tube exposure, although porcine pericardium was associated with greater inflammation through clinical observation. Light microscopy revealed marked inflammation surrounding the porcine pericardium with foreign body granuloma formation. On the other hand, the sclera group presented milder inflammation with foreign body granulomas only around the sutures. CONCLUSIONS: Porcine pericardium is associated with significant inflammation when used as tube coverage in a rabbit model, at both histopathologic and clinical levels, when compared to glycerin-preserved homologous sclera during the seven-week follow-up period. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-10-01 2015-06-14T13:38:46Z 2015-06-14T13:38:46Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-27492008000500003 Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 71, n. 5, p. 623-628, 2008. 10.1590/S0004-27492008000500003 S0004-27492008000500003.pdf 0004-2749 S0004-27492008000500003 http://repositorio.unifesp.br/handle/11600/4592 |
url |
http://dx.doi.org/10.1590/S0004-27492008000500003 http://repositorio.unifesp.br/handle/11600/4592 |
identifier_str_mv |
Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 71, n. 5, p. 623-628, 2008. 10.1590/S0004-27492008000500003 S0004-27492008000500003.pdf 0004-2749 S0004-27492008000500003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
623-628 application/pdf |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268274275254272 |