Acute and short-term effect of an extra dose of formoterol in COPD patients

• Autor(a) principal: Studart, Fernando Sérgio [UNIFESP]
• Data de Publicação: 2012
• Outros Autores: Izbicki, Meyer [UNIFESP], Nery, Luiz Eduardo [UNIFESP], Oliveira, Luis Vicente Franco, Donner, Claudio F., Jardim, José Roberto [UNIFESP], Nascimento, Oliver Augusto [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1016/j.rmed.2011.12.015; http://repositorio.unifesp.br/handle/11600/34911
• topic: COPD; Formoterol; Hyperinflation

Rationale: Formoterol action may decrease progressively after its inhalation. It is unknown if this decrease of bronchodilation following formoterol use could be associated with worsening hyperinflation.Objectives: To investigate whether the use of an extra daily dose of formoterol could promote a greater reduction in lung hyperinflation and a greater improvement in inspiratory capacity (IC) compared to usual doses.Methods: 56 hyperinflated COPD patients were divided into two groups: F2 and F3. Basal evaluation was carried out after 5 days of formoterol washout. in order to evaluate the acute effect, spirometry and body plethysmography were performed 8 h after the first formoterol dose in both groups and repeated 1 h after an additional formoterol dose (F3) or placebo (F2). the short-term effect was evaluated by measuring the resting lung function after a 14-day period of formoterol t.i.d. (F3) or formoterol b.i.d. + placebo (F2).Measurements and main results: A second formoterol dose inhaled 8 h after the previous dose promoted additional improvements in lung function, as demonstrated by higher IC (118 +/- 140 mL, p < 0.001) and tower functional residual capacity (FRC) (-383 +/- 367 mL, p <0.001). On day 15, the mean differences from baseline regarding all lung function variables were similar between the groups.Conclusion: An extra daily dose of formoterol inhaled 8 h after a previous dose could result in an acute additional peak of bronchodilation. However, short-term formoterol t.i.d. showed no advantages over formoterol b.i.d. concerning reduction of hyperinflation in resting lung function. (C) 2012 Elsevier B.V. All rights reserved.