Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2001 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/0013000018c1f |
| Texto Completo: | http://dx.doi.org/10.1590/S0004-282X2001000600016 http://repositorio.unifesp.br/handle/11600/1291 |
Resumo: | Twenty-two patients with astrocytomas, grade II or III WHO, were studied from 1990 to 1998. In all cases, histopathology showed that the astrocytomas had a gemistocytic component. The aims of this study were to establish the fraction of gemistocytic astrocytes, to investigate p53 protein immunoexpression and to evaluate correlations between these two parameters with the tumour outcome. Tumor cells were quantified at high-power magnification (x400). At least 1000 neoplastic cells (small neoplastic astrocytes plus gemistocytes) were counted in each specimen. The percentage of gemistocytes was defined as the gemistocytic index. Nuclear expression of p53 protein was evaluated in neoplastic astrocytes and gemistocytes. Both the frequency (7/22) as well the p53 immunoexpression indices in gemistocytes, regardless of the grade of the astrocytomas, were inferior from those reported in the literature. No correlation was found between the gemistocytic indices and the p53 immunoexpression. |
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Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMSFraction of gemistocytic astrocytes and immunoexpression of p53 protein in astrocytomas grade II and III (WHO)gemistocytesp53astrocytomagliomagemistocitop53astrocitomagliomaTwenty-two patients with astrocytomas, grade II or III WHO, were studied from 1990 to 1998. In all cases, histopathology showed that the astrocytomas had a gemistocytic component. The aims of this study were to establish the fraction of gemistocytic astrocytes, to investigate p53 protein immunoexpression and to evaluate correlations between these two parameters with the tumour outcome. Tumor cells were quantified at high-power magnification (x400). At least 1000 neoplastic cells (small neoplastic astrocytes plus gemistocytes) were counted in each specimen. The percentage of gemistocytes was defined as the gemistocytic index. Nuclear expression of p53 protein was evaluated in neoplastic astrocytes and gemistocytes. Both the frequency (7/22) as well the p53 immunoexpression indices in gemistocytes, regardless of the grade of the astrocytomas, were inferior from those reported in the literature. No correlation was found between the gemistocytic indices and the p53 immunoexpression.Foram estudados, retrospectivamente, 22 pacientes com diagnóstico de astrocitomas grau II (n=17) e III (n=5), OMS, no período de 1990 a 1998, cujos laudos histopatológicos descreviam a presença gemistocitos com o objetivo de determinar o índice de astrócitos gemistocíticos, investigar a imuno-expressão da proteína p53 e confrontá-los com o intervalo até a recorrência da neoplasia. O índice de astrócitos gemistocíticos, em cada caso, foi calculado a partir da razão entre o número de gemistocitos e o número total de células neoplásicas contadas, no mínimo 1000. Imuno-expressão nuclear da proteína p53 foi avaliada em astrócitos e gemistocitos neoplásicos; tanto a freqüência (7/22), como o índice de imuno-expressão positiva da p53 em gemistocitos, independentemente do grau histológico da neoplasia, foram inferiores aos relatados na literatura. Não se observou correlação entre o índice de astrócitos gemistocíticos e a imuno-expressão positiva da p53.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PatologiaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de NeurologiaUNIFESP, EPM, Depto. de PatologiaUNIFESP, EPM, Disciplina de NeurologiaSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Martins, Dely Cristina [UNIFESP]Stávale, João Norberto [UNIFESP]Malheiros, Suzana Maria Fleury [UNIFESP]Santiago, Lucila Heloisa Simardi [UNIFESP]Roman, Leonor Cristina Manoja [UNIFESP]Aguiar, Kátia Cilene Carozzi [UNIFESP]2015-06-14T13:29:33Z2015-06-14T13:29:33Z2001-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion926-931application/pdfhttp://dx.doi.org/10.1590/S0004-282X2001000600016Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 59, n. 4, p. 926-931, 2001.10.1590/S0004-282X2001000600016S0004-282X2001000600016.pdf0004-282XS0004-282X2001000600016http://repositorio.unifesp.br/handle/11600/1291ark:/48912/0013000018c1fporArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-27T17:31:15Zoai:repositorio.unifesp.br/:11600/1291Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T21:03:31.200293Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS Fraction of gemistocytic astrocytes and immunoexpression of p53 protein in astrocytomas grade II and III (WHO) |
| title |
Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS |
| spellingShingle |
Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS Martins, Dely Cristina [UNIFESP] gemistocytes p53 astrocytoma glioma gemistocito p53 astrocitoma glioma |
| title_short |
Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS |
| title_full |
Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS |
| title_fullStr |
Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS |
| title_full_unstemmed |
Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS |
| title_sort |
Índice de astrócitos gemistocíticos e imuno-expressão da proteína p53 em astrocitomas, grau II e III OMS |
| author |
Martins, Dely Cristina [UNIFESP] |
| author_facet |
Martins, Dely Cristina [UNIFESP] Stávale, João Norberto [UNIFESP] Malheiros, Suzana Maria Fleury [UNIFESP] Santiago, Lucila Heloisa Simardi [UNIFESP] Roman, Leonor Cristina Manoja [UNIFESP] Aguiar, Kátia Cilene Carozzi [UNIFESP] |
| author_role |
author |
| author2 |
Stávale, João Norberto [UNIFESP] Malheiros, Suzana Maria Fleury [UNIFESP] Santiago, Lucila Heloisa Simardi [UNIFESP] Roman, Leonor Cristina Manoja [UNIFESP] Aguiar, Kátia Cilene Carozzi [UNIFESP] |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Martins, Dely Cristina [UNIFESP] Stávale, João Norberto [UNIFESP] Malheiros, Suzana Maria Fleury [UNIFESP] Santiago, Lucila Heloisa Simardi [UNIFESP] Roman, Leonor Cristina Manoja [UNIFESP] Aguiar, Kátia Cilene Carozzi [UNIFESP] |
| dc.subject.por.fl_str_mv |
gemistocytes p53 astrocytoma glioma gemistocito p53 astrocitoma glioma |
| topic |
gemistocytes p53 astrocytoma glioma gemistocito p53 astrocitoma glioma |
| description |
Twenty-two patients with astrocytomas, grade II or III WHO, were studied from 1990 to 1998. In all cases, histopathology showed that the astrocytomas had a gemistocytic component. The aims of this study were to establish the fraction of gemistocytic astrocytes, to investigate p53 protein immunoexpression and to evaluate correlations between these two parameters with the tumour outcome. Tumor cells were quantified at high-power magnification (x400). At least 1000 neoplastic cells (small neoplastic astrocytes plus gemistocytes) were counted in each specimen. The percentage of gemistocytes was defined as the gemistocytic index. Nuclear expression of p53 protein was evaluated in neoplastic astrocytes and gemistocytes. Both the frequency (7/22) as well the p53 immunoexpression indices in gemistocytes, regardless of the grade of the astrocytomas, were inferior from those reported in the literature. No correlation was found between the gemistocytic indices and the p53 immunoexpression. |
| publishDate |
2001 |
| dc.date.none.fl_str_mv |
2001-12-01 2015-06-14T13:29:33Z 2015-06-14T13:29:33Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-282X2001000600016 Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 59, n. 4, p. 926-931, 2001. 10.1590/S0004-282X2001000600016 S0004-282X2001000600016.pdf 0004-282X S0004-282X2001000600016 http://repositorio.unifesp.br/handle/11600/1291 |
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ark:/48912/0013000018c1f |
| url |
http://dx.doi.org/10.1590/S0004-282X2001000600016 http://repositorio.unifesp.br/handle/11600/1291 |
| identifier_str_mv |
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 59, n. 4, p. 926-931, 2001. 10.1590/S0004-282X2001000600016 S0004-282X2001000600016.pdf 0004-282X S0004-282X2001000600016 ark:/48912/0013000018c1f |
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por |
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por |
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Arquivos de Neuro-Psiquiatria |
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info:eu-repo/semantics/openAccess |
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openAccess |
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926-931 application/pdf |
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Academia Brasileira de Neurologia - ABNEURO |
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Academia Brasileira de Neurologia - ABNEURO |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1818602594198618112 |