Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.3389/fphar.2016.00420 https://repositorio.unifesp.br/handle/11600/56722 |
Resumo: | There is substantial controversy about the addictive potential of modafinil, a wake promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration. |
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Repositório Institucional da UNIFESP |
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Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinilcocainedrug abusemicemodafinilopen fieldrapid-onset behavioral sensitizationThere is substantial controversy about the addictive potential of modafinil, a wake promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration.Univ Fed Sao Paulo, Dept Physiol, Lab Neurophysiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, BrazilUniv Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP, BrazilLaboratory of Neurophysiology, Department of Physiology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Pharmacology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundo de Auxílio aos Docentes e Alunos (FADA)Associação Fundo de Incentivo à Psicofarmacologia (AFIP)FAPESP: 2014/24277-4Frontiers Media Sa2020-07-31T12:47:17Z2020-07-31T12:47:17Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-http://dx.doi.org/10.3389/fphar.2016.00420Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.10.3389/fphar.2016.00420WOS000387083100001.pdf1663-9812https://repositorio.unifesp.br/handle/11600/56722WOS:000387083100001engFrontiers In PharmacologyLausanneinfo:eu-repo/semantics/openAccessWuo-Silva, Raphael [UNIFESP]Fukushiro, Daniela Fukue [UNIFESP]Hollais, André Willian [UNIFESP]Santos-Baldaia, Renan [UNIFESP]Mari-Kawamoto, Elisa [UNIFESP]Berro, Laís Fernanda [UNIFESP]Yokoyama, Thais Suemi [UNIFESP]Lopes-Silva, Leonardo Brito [UNIFESP]Bizerra, Carolina Souza [UNIFESP]Procopio-Souza, Roberta [UNIFESP]Hashiguchi, Debora [UNIFESP]Figueiredo, Lilian A. [UNIFESP]Costa, Jose L.Frussa-Filho, Roberto [UNIFESP]Longo, Beatriz Monteiro [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T15:50:03Zoai:repositorio.unifesp.br/:11600/56722Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T15:50:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil |
title |
Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil |
spellingShingle |
Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil Wuo-Silva, Raphael [UNIFESP] cocaine drug abuse mice modafinil open field rapid-onset behavioral sensitization |
title_short |
Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil |
title_full |
Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil |
title_fullStr |
Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil |
title_full_unstemmed |
Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil |
title_sort |
Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil |
author |
Wuo-Silva, Raphael [UNIFESP] |
author_facet |
Wuo-Silva, Raphael [UNIFESP] Fukushiro, Daniela Fukue [UNIFESP] Hollais, André Willian [UNIFESP] Santos-Baldaia, Renan [UNIFESP] Mari-Kawamoto, Elisa [UNIFESP] Berro, Laís Fernanda [UNIFESP] Yokoyama, Thais Suemi [UNIFESP] Lopes-Silva, Leonardo Brito [UNIFESP] Bizerra, Carolina Souza [UNIFESP] Procopio-Souza, Roberta [UNIFESP] Hashiguchi, Debora [UNIFESP] Figueiredo, Lilian A. [UNIFESP] Costa, Jose L. Frussa-Filho, Roberto [UNIFESP] Longo, Beatriz Monteiro [UNIFESP] |
author_role |
author |
author2 |
Fukushiro, Daniela Fukue [UNIFESP] Hollais, André Willian [UNIFESP] Santos-Baldaia, Renan [UNIFESP] Mari-Kawamoto, Elisa [UNIFESP] Berro, Laís Fernanda [UNIFESP] Yokoyama, Thais Suemi [UNIFESP] Lopes-Silva, Leonardo Brito [UNIFESP] Bizerra, Carolina Souza [UNIFESP] Procopio-Souza, Roberta [UNIFESP] Hashiguchi, Debora [UNIFESP] Figueiredo, Lilian A. [UNIFESP] Costa, Jose L. Frussa-Filho, Roberto [UNIFESP] Longo, Beatriz Monteiro [UNIFESP] |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Wuo-Silva, Raphael [UNIFESP] Fukushiro, Daniela Fukue [UNIFESP] Hollais, André Willian [UNIFESP] Santos-Baldaia, Renan [UNIFESP] Mari-Kawamoto, Elisa [UNIFESP] Berro, Laís Fernanda [UNIFESP] Yokoyama, Thais Suemi [UNIFESP] Lopes-Silva, Leonardo Brito [UNIFESP] Bizerra, Carolina Souza [UNIFESP] Procopio-Souza, Roberta [UNIFESP] Hashiguchi, Debora [UNIFESP] Figueiredo, Lilian A. [UNIFESP] Costa, Jose L. Frussa-Filho, Roberto [UNIFESP] Longo, Beatriz Monteiro [UNIFESP] |
dc.subject.por.fl_str_mv |
cocaine drug abuse mice modafinil open field rapid-onset behavioral sensitization |
topic |
cocaine drug abuse mice modafinil open field rapid-onset behavioral sensitization |
description |
There is substantial controversy about the addictive potential of modafinil, a wake promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2020-07-31T12:47:17Z 2020-07-31T12:47:17Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fphar.2016.00420 Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016. 10.3389/fphar.2016.00420 WOS000387083100001.pdf 1663-9812 https://repositorio.unifesp.br/handle/11600/56722 WOS:000387083100001 |
url |
http://dx.doi.org/10.3389/fphar.2016.00420 https://repositorio.unifesp.br/handle/11600/56722 |
identifier_str_mv |
Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016. 10.3389/fphar.2016.00420 WOS000387083100001.pdf 1663-9812 WOS:000387083100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers In Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- |
dc.coverage.none.fl_str_mv |
Lausanne |
dc.publisher.none.fl_str_mv |
Frontiers Media Sa |
publisher.none.fl_str_mv |
Frontiers Media Sa |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268369059184640 |