Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil

Detalhes bibliográficos
Autor(a) principal: Wuo-Silva, Raphael [UNIFESP]
Data de Publicação: 2016
Outros Autores: Fukushiro, Daniela Fukue [UNIFESP], Hollais, André Willian [UNIFESP], Santos-Baldaia, Renan [UNIFESP], Mari-Kawamoto, Elisa [UNIFESP], Berro, Laís Fernanda [UNIFESP], Yokoyama, Thais Suemi [UNIFESP], Lopes-Silva, Leonardo Brito [UNIFESP], Bizerra, Carolina Souza [UNIFESP], Procopio-Souza, Roberta [UNIFESP], Hashiguchi, Debora [UNIFESP], Figueiredo, Lilian A. [UNIFESP], Costa, Jose L., Frussa-Filho, Roberto [UNIFESP], Longo, Beatriz Monteiro [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.3389/fphar.2016.00420
https://repositorio.unifesp.br/handle/11600/56722
Resumo: There is substantial controversy about the addictive potential of modafinil, a wake promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration.
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spelling Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinilcocainedrug abusemicemodafinilopen fieldrapid-onset behavioral sensitizationThere is substantial controversy about the addictive potential of modafinil, a wake promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration.Univ Fed Sao Paulo, Dept Physiol, Lab Neurophysiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, BrazilUniv Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP, BrazilLaboratory of Neurophysiology, Department of Physiology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Pharmacology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundo de Auxílio aos Docentes e Alunos (FADA)Associação Fundo de Incentivo à Psicofarmacologia (AFIP)FAPESP: 2014/24277-4Frontiers Media Sa2020-07-31T12:47:17Z2020-07-31T12:47:17Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-http://dx.doi.org/10.3389/fphar.2016.00420Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.10.3389/fphar.2016.00420WOS000387083100001.pdf1663-9812https://repositorio.unifesp.br/handle/11600/56722WOS:000387083100001engFrontiers In PharmacologyLausanneinfo:eu-repo/semantics/openAccessWuo-Silva, Raphael [UNIFESP]Fukushiro, Daniela Fukue [UNIFESP]Hollais, André Willian [UNIFESP]Santos-Baldaia, Renan [UNIFESP]Mari-Kawamoto, Elisa [UNIFESP]Berro, Laís Fernanda [UNIFESP]Yokoyama, Thais Suemi [UNIFESP]Lopes-Silva, Leonardo Brito [UNIFESP]Bizerra, Carolina Souza [UNIFESP]Procopio-Souza, Roberta [UNIFESP]Hashiguchi, Debora [UNIFESP]Figueiredo, Lilian A. [UNIFESP]Costa, Jose L.Frussa-Filho, Roberto [UNIFESP]Longo, Beatriz Monteiro [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T15:50:03Zoai:repositorio.unifesp.br/:11600/56722Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T15:50:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
title Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
spellingShingle Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
Wuo-Silva, Raphael [UNIFESP]
cocaine
drug abuse
mice
modafinil
open field
rapid-onset behavioral sensitization
title_short Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
title_full Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
title_fullStr Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
title_full_unstemmed Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
title_sort Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
author Wuo-Silva, Raphael [UNIFESP]
author_facet Wuo-Silva, Raphael [UNIFESP]
Fukushiro, Daniela Fukue [UNIFESP]
Hollais, André Willian [UNIFESP]
Santos-Baldaia, Renan [UNIFESP]
Mari-Kawamoto, Elisa [UNIFESP]
Berro, Laís Fernanda [UNIFESP]
Yokoyama, Thais Suemi [UNIFESP]
Lopes-Silva, Leonardo Brito [UNIFESP]
Bizerra, Carolina Souza [UNIFESP]
Procopio-Souza, Roberta [UNIFESP]
Hashiguchi, Debora [UNIFESP]
Figueiredo, Lilian A. [UNIFESP]
Costa, Jose L.
Frussa-Filho, Roberto [UNIFESP]
Longo, Beatriz Monteiro [UNIFESP]
author_role author
author2 Fukushiro, Daniela Fukue [UNIFESP]
Hollais, André Willian [UNIFESP]
Santos-Baldaia, Renan [UNIFESP]
Mari-Kawamoto, Elisa [UNIFESP]
Berro, Laís Fernanda [UNIFESP]
Yokoyama, Thais Suemi [UNIFESP]
Lopes-Silva, Leonardo Brito [UNIFESP]
Bizerra, Carolina Souza [UNIFESP]
Procopio-Souza, Roberta [UNIFESP]
Hashiguchi, Debora [UNIFESP]
Figueiredo, Lilian A. [UNIFESP]
Costa, Jose L.
Frussa-Filho, Roberto [UNIFESP]
Longo, Beatriz Monteiro [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wuo-Silva, Raphael [UNIFESP]
Fukushiro, Daniela Fukue [UNIFESP]
Hollais, André Willian [UNIFESP]
Santos-Baldaia, Renan [UNIFESP]
Mari-Kawamoto, Elisa [UNIFESP]
Berro, Laís Fernanda [UNIFESP]
Yokoyama, Thais Suemi [UNIFESP]
Lopes-Silva, Leonardo Brito [UNIFESP]
Bizerra, Carolina Souza [UNIFESP]
Procopio-Souza, Roberta [UNIFESP]
Hashiguchi, Debora [UNIFESP]
Figueiredo, Lilian A. [UNIFESP]
Costa, Jose L.
Frussa-Filho, Roberto [UNIFESP]
Longo, Beatriz Monteiro [UNIFESP]
dc.subject.por.fl_str_mv cocaine
drug abuse
mice
modafinil
open field
rapid-onset behavioral sensitization
topic cocaine
drug abuse
mice
modafinil
open field
rapid-onset behavioral sensitization
description There is substantial controversy about the addictive potential of modafinil, a wake promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-07-31T12:47:17Z
2020-07-31T12:47:17Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3389/fphar.2016.00420
Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.
10.3389/fphar.2016.00420
WOS000387083100001.pdf
1663-9812
https://repositorio.unifesp.br/handle/11600/56722
WOS:000387083100001
url http://dx.doi.org/10.3389/fphar.2016.00420
https://repositorio.unifesp.br/handle/11600/56722
identifier_str_mv Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.
10.3389/fphar.2016.00420
WOS000387083100001.pdf
1663-9812
WOS:000387083100001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers In Pharmacology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
dc.coverage.none.fl_str_mv Lausanne
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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