Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials

Detalhes bibliográficos
Autor(a) principal: Silva, Ricardo Carvalho Lopes
Data de Publicação: 2011
Outros Autores: Riera, Rachel [UNIFESP], Saconato, Humberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1516-31802011000500009
http://repositorio.unifesp.br/handle/11600/6241
Resumo: CONTEXT AND OBJECTIVE: Lumiracoxib is an anti-inflammatory drug that has been used to treat acute dental pain, mainly in postsurgical settings, in which the greatest levels of pain and discomfort are experienced during the first 24 hours. This study aimed to assess the efficacy and safety of lumiracoxib for treating acute postsurgical dental pain. DESIGN AND SETTING: Systematic review developed at the Brazilian Cochrane Centre, Universidade Federal de São Paulo (UNIFESP). METHODS: An electronic search was conducted in the PubMed, Cochrane Library, Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Embase databases. A manual search was also performed. Only randomized controlled trials were included, and these were selected and assessed by two researchers with regard to the risk of bias. RESULTS: Three clinical trials with 921 participants were included. Lumiracoxib 400 mg produced onset of analgesia in a shorter time than shown by lumiracoxib 100 mg, celecoxib 200 mg and ibuprofen 400 mg. There was no difference between lumiracoxib 400 mg and rofecoxib 50 mg. In two studies, the mean time taken to attain onset of analgesia for the placebo was not estimated because the number of participants who reached onset was too small. CONCLUSION: There is evidence with a moderate risk of bias that recommends the use of lumiracoxib for acute postoperative dental pain. However, the adverse effects are not completely known. Given that lumiracoxib is currently available in only three countries, further studies are likely to be rare and discouraged.
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spelling Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trialsLumiracoxibe para dor dental aguda e pós-operatória: uma revisão sistemática de ensaios clínicos randomizadosAnti-inflammatory agentsAnalgesiaCyclooxygenase 2 inhibitorsPainReview [publication type]AntiinflamatóriosAnalgesiaInibidores de ciclooxigenase 2DorRevisãoCONTEXT AND OBJECTIVE: Lumiracoxib is an anti-inflammatory drug that has been used to treat acute dental pain, mainly in postsurgical settings, in which the greatest levels of pain and discomfort are experienced during the first 24 hours. This study aimed to assess the efficacy and safety of lumiracoxib for treating acute postsurgical dental pain. DESIGN AND SETTING: Systematic review developed at the Brazilian Cochrane Centre, Universidade Federal de São Paulo (UNIFESP). METHODS: An electronic search was conducted in the PubMed, Cochrane Library, Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Embase databases. A manual search was also performed. Only randomized controlled trials were included, and these were selected and assessed by two researchers with regard to the risk of bias. RESULTS: Three clinical trials with 921 participants were included. Lumiracoxib 400 mg produced onset of analgesia in a shorter time than shown by lumiracoxib 100 mg, celecoxib 200 mg and ibuprofen 400 mg. There was no difference between lumiracoxib 400 mg and rofecoxib 50 mg. In two studies, the mean time taken to attain onset of analgesia for the placebo was not estimated because the number of participants who reached onset was too small. CONCLUSION: There is evidence with a moderate risk of bias that recommends the use of lumiracoxib for acute postoperative dental pain. However, the adverse effects are not completely known. Given that lumiracoxib is currently available in only three countries, further studies are likely to be rare and discouraged.CONTEXTO E OBJETIVO: O lumiracoxibe é um anti-inflamatório que tem sido utilizado no tratamento de dor dental aguda, principalmente no cenário pós-cirúrgico, no qual níveis mais elevados de dor e desconforto são sentidos durante as primeiras 24 horas. Este estudo teve por objetivo avaliar a eficácia e a segurança do lumiracoxibe no tratamento da dor dental aguda e pós-operatória. TIPO DE ESTUDO E LOCAL: Revisão sistemática desenvolvida no Centro Cochrane do Brasil, Universidade Federal de São Paulo (UNIFESP). MÉTODOS: Foi realizada busca eletrônica nas bases de dados PubMed, Cochrane Library, Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) e Embase. Também foi realizada busca manual. Apenas ensaios clínicos randomizados foram incluídos e foram selecionados e avaliados por dois pesquisadores quanto ao risco de viés. RESULTADOS: Foram incluídos três ensaios clínicos com 921 participantes. O lumiracoxibe 400 mg mostrou menor tempo de início de analgesia que o lumiracoxibe 100 mg, celecoxibe 200 mg e ibuprofeno de 400 mg. Não houve diferença entre lumiracoxibe 400 mg e rofecoxibe 50 mg. Em dois estudos o tempo médio de início de analgesia para o placebo não foi estimado, pois o número de participantes que a alcançou foi pequeno. CONCLUSÃO: Há evidências, com moderado risco de viés, que recomendam o uso de lumiracoxibe para a dor dental aguda e pós-operatória. No entanto, os efeitos adversos não são completamente conhecidos. Considerando que o lumiracoxibe está disponível em apenas três países, provavelmente a realização de pesquisas futuras será rara e desestimulada.Universidade Federal de São Paulo (UNIFESP)Brazilian Cochrane CenterUniversidade Federal do Rio Grande do NorteUNIFESPSciELOAssociação Paulista de Medicina - APMUniversidade Federal de São Paulo (UNIFESP)Brazilian Cochrane CenterUniversidade Federal do Rio Grande do NorteSilva, Ricardo Carvalho LopesRiera, Rachel [UNIFESP]Saconato, Humberto2015-06-14T13:42:51Z2015-06-14T13:42:51Z2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion335-345application/pdfhttp://dx.doi.org/10.1590/S1516-31802011000500009SILVA, Ricardo Carvalho Lopes; RIERA, Rachel; SACONATO, Humberto. Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials. Sao Paulo Med. J., São Paulo , v. 129, n. 5, p. 335-345, 201110.1590/S1516-31802011000500009S1516-31802011000500009.pdf1516-3180S1516-31802011000500009http://repositorio.unifesp.br/handle/11600/6241WOS:000297807100009engSão Paulo Medical Journalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T21:40:51Zoai:repositorio.unifesp.br/:11600/6241Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T21:40:51Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
Lumiracoxibe para dor dental aguda e pós-operatória: uma revisão sistemática de ensaios clínicos randomizados
title Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
spellingShingle Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
Silva, Ricardo Carvalho Lopes
Anti-inflammatory agents
Analgesia
Cyclooxygenase 2 inhibitors
Pain
Review [publication type]
Antiinflamatórios
Analgesia
Inibidores de ciclooxigenase 2
Dor
Revisão
title_short Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
title_full Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
title_fullStr Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
title_full_unstemmed Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
title_sort Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
author Silva, Ricardo Carvalho Lopes
author_facet Silva, Ricardo Carvalho Lopes
Riera, Rachel [UNIFESP]
Saconato, Humberto
author_role author
author2 Riera, Rachel [UNIFESP]
Saconato, Humberto
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Brazilian Cochrane Center
Universidade Federal do Rio Grande do Norte
dc.contributor.author.fl_str_mv Silva, Ricardo Carvalho Lopes
Riera, Rachel [UNIFESP]
Saconato, Humberto
dc.subject.por.fl_str_mv Anti-inflammatory agents
Analgesia
Cyclooxygenase 2 inhibitors
Pain
Review [publication type]
Antiinflamatórios
Analgesia
Inibidores de ciclooxigenase 2
Dor
Revisão
topic Anti-inflammatory agents
Analgesia
Cyclooxygenase 2 inhibitors
Pain
Review [publication type]
Antiinflamatórios
Analgesia
Inibidores de ciclooxigenase 2
Dor
Revisão
description CONTEXT AND OBJECTIVE: Lumiracoxib is an anti-inflammatory drug that has been used to treat acute dental pain, mainly in postsurgical settings, in which the greatest levels of pain and discomfort are experienced during the first 24 hours. This study aimed to assess the efficacy and safety of lumiracoxib for treating acute postsurgical dental pain. DESIGN AND SETTING: Systematic review developed at the Brazilian Cochrane Centre, Universidade Federal de São Paulo (UNIFESP). METHODS: An electronic search was conducted in the PubMed, Cochrane Library, Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Embase databases. A manual search was also performed. Only randomized controlled trials were included, and these were selected and assessed by two researchers with regard to the risk of bias. RESULTS: Three clinical trials with 921 participants were included. Lumiracoxib 400 mg produced onset of analgesia in a shorter time than shown by lumiracoxib 100 mg, celecoxib 200 mg and ibuprofen 400 mg. There was no difference between lumiracoxib 400 mg and rofecoxib 50 mg. In two studies, the mean time taken to attain onset of analgesia for the placebo was not estimated because the number of participants who reached onset was too small. CONCLUSION: There is evidence with a moderate risk of bias that recommends the use of lumiracoxib for acute postoperative dental pain. However, the adverse effects are not completely known. Given that lumiracoxib is currently available in only three countries, further studies are likely to be rare and discouraged.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
2015-06-14T13:42:51Z
2015-06-14T13:42:51Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-31802011000500009
SILVA, Ricardo Carvalho Lopes; RIERA, Rachel; SACONATO, Humberto. Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials. Sao Paulo Med. J., São Paulo , v. 129, n. 5, p. 335-345, 2011
10.1590/S1516-31802011000500009
S1516-31802011000500009.pdf
1516-3180
S1516-31802011000500009
http://repositorio.unifesp.br/handle/11600/6241
WOS:000297807100009
url http://dx.doi.org/10.1590/S1516-31802011000500009
http://repositorio.unifesp.br/handle/11600/6241
identifier_str_mv SILVA, Ricardo Carvalho Lopes; RIERA, Rachel; SACONATO, Humberto. Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials. Sao Paulo Med. J., São Paulo , v. 129, n. 5, p. 335-345, 2011
10.1590/S1516-31802011000500009
S1516-31802011000500009.pdf
1516-3180
S1516-31802011000500009
WOS:000297807100009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv São Paulo Medical Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 335-345
application/pdf
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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