Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1516-31802011000500009 http://repositorio.unifesp.br/handle/11600/6241 |
Resumo: | CONTEXT AND OBJECTIVE: Lumiracoxib is an anti-inflammatory drug that has been used to treat acute dental pain, mainly in postsurgical settings, in which the greatest levels of pain and discomfort are experienced during the first 24 hours. This study aimed to assess the efficacy and safety of lumiracoxib for treating acute postsurgical dental pain. DESIGN AND SETTING: Systematic review developed at the Brazilian Cochrane Centre, Universidade Federal de São Paulo (UNIFESP). METHODS: An electronic search was conducted in the PubMed, Cochrane Library, Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Embase databases. A manual search was also performed. Only randomized controlled trials were included, and these were selected and assessed by two researchers with regard to the risk of bias. RESULTS: Three clinical trials with 921 participants were included. Lumiracoxib 400 mg produced onset of analgesia in a shorter time than shown by lumiracoxib 100 mg, celecoxib 200 mg and ibuprofen 400 mg. There was no difference between lumiracoxib 400 mg and rofecoxib 50 mg. In two studies, the mean time taken to attain onset of analgesia for the placebo was not estimated because the number of participants who reached onset was too small. CONCLUSION: There is evidence with a moderate risk of bias that recommends the use of lumiracoxib for acute postoperative dental pain. However, the adverse effects are not completely known. Given that lumiracoxib is currently available in only three countries, further studies are likely to be rare and discouraged. |
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Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trialsLumiracoxibe para dor dental aguda e pós-operatória: uma revisão sistemática de ensaios clínicos randomizadosAnti-inflammatory agentsAnalgesiaCyclooxygenase 2 inhibitorsPainReview [publication type]AntiinflamatóriosAnalgesiaInibidores de ciclooxigenase 2DorRevisãoCONTEXT AND OBJECTIVE: Lumiracoxib is an anti-inflammatory drug that has been used to treat acute dental pain, mainly in postsurgical settings, in which the greatest levels of pain and discomfort are experienced during the first 24 hours. This study aimed to assess the efficacy and safety of lumiracoxib for treating acute postsurgical dental pain. DESIGN AND SETTING: Systematic review developed at the Brazilian Cochrane Centre, Universidade Federal de São Paulo (UNIFESP). METHODS: An electronic search was conducted in the PubMed, Cochrane Library, Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Embase databases. A manual search was also performed. Only randomized controlled trials were included, and these were selected and assessed by two researchers with regard to the risk of bias. RESULTS: Three clinical trials with 921 participants were included. Lumiracoxib 400 mg produced onset of analgesia in a shorter time than shown by lumiracoxib 100 mg, celecoxib 200 mg and ibuprofen 400 mg. There was no difference between lumiracoxib 400 mg and rofecoxib 50 mg. In two studies, the mean time taken to attain onset of analgesia for the placebo was not estimated because the number of participants who reached onset was too small. CONCLUSION: There is evidence with a moderate risk of bias that recommends the use of lumiracoxib for acute postoperative dental pain. However, the adverse effects are not completely known. Given that lumiracoxib is currently available in only three countries, further studies are likely to be rare and discouraged.CONTEXTO E OBJETIVO: O lumiracoxibe é um anti-inflamatório que tem sido utilizado no tratamento de dor dental aguda, principalmente no cenário pós-cirúrgico, no qual níveis mais elevados de dor e desconforto são sentidos durante as primeiras 24 horas. Este estudo teve por objetivo avaliar a eficácia e a segurança do lumiracoxibe no tratamento da dor dental aguda e pós-operatória. TIPO DE ESTUDO E LOCAL: Revisão sistemática desenvolvida no Centro Cochrane do Brasil, Universidade Federal de São Paulo (UNIFESP). MÉTODOS: Foi realizada busca eletrônica nas bases de dados PubMed, Cochrane Library, Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) e Embase. Também foi realizada busca manual. Apenas ensaios clínicos randomizados foram incluídos e foram selecionados e avaliados por dois pesquisadores quanto ao risco de viés. RESULTADOS: Foram incluídos três ensaios clínicos com 921 participantes. O lumiracoxibe 400 mg mostrou menor tempo de início de analgesia que o lumiracoxibe 100 mg, celecoxibe 200 mg e ibuprofeno de 400 mg. Não houve diferença entre lumiracoxibe 400 mg e rofecoxibe 50 mg. Em dois estudos o tempo médio de início de analgesia para o placebo não foi estimado, pois o número de participantes que a alcançou foi pequeno. CONCLUSÃO: Há evidências, com moderado risco de viés, que recomendam o uso de lumiracoxibe para a dor dental aguda e pós-operatória. No entanto, os efeitos adversos não são completamente conhecidos. Considerando que o lumiracoxibe está disponível em apenas três países, provavelmente a realização de pesquisas futuras será rara e desestimulada.Universidade Federal de São Paulo (UNIFESP)Brazilian Cochrane CenterUniversidade Federal do Rio Grande do NorteUNIFESPSciELOAssociação Paulista de Medicina - APMUniversidade Federal de São Paulo (UNIFESP)Brazilian Cochrane CenterUniversidade Federal do Rio Grande do NorteSilva, Ricardo Carvalho LopesRiera, Rachel [UNIFESP]Saconato, Humberto2015-06-14T13:42:51Z2015-06-14T13:42:51Z2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion335-345application/pdfhttp://dx.doi.org/10.1590/S1516-31802011000500009SILVA, Ricardo Carvalho Lopes; RIERA, Rachel; SACONATO, Humberto. Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials. Sao Paulo Med. J., São Paulo , v. 129, n. 5, p. 335-345, 201110.1590/S1516-31802011000500009S1516-31802011000500009.pdf1516-3180S1516-31802011000500009http://repositorio.unifesp.br/handle/11600/6241WOS:000297807100009engSão Paulo Medical Journalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T21:40:51Zoai:repositorio.unifesp.br/:11600/6241Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T21:40:51Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials Lumiracoxibe para dor dental aguda e pós-operatória: uma revisão sistemática de ensaios clínicos randomizados |
title |
Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials |
spellingShingle |
Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials Silva, Ricardo Carvalho Lopes Anti-inflammatory agents Analgesia Cyclooxygenase 2 inhibitors Pain Review [publication type] Antiinflamatórios Analgesia Inibidores de ciclooxigenase 2 Dor Revisão |
title_short |
Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials |
title_full |
Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials |
title_fullStr |
Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials |
title_full_unstemmed |
Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials |
title_sort |
Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials |
author |
Silva, Ricardo Carvalho Lopes |
author_facet |
Silva, Ricardo Carvalho Lopes Riera, Rachel [UNIFESP] Saconato, Humberto |
author_role |
author |
author2 |
Riera, Rachel [UNIFESP] Saconato, Humberto |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Brazilian Cochrane Center Universidade Federal do Rio Grande do Norte |
dc.contributor.author.fl_str_mv |
Silva, Ricardo Carvalho Lopes Riera, Rachel [UNIFESP] Saconato, Humberto |
dc.subject.por.fl_str_mv |
Anti-inflammatory agents Analgesia Cyclooxygenase 2 inhibitors Pain Review [publication type] Antiinflamatórios Analgesia Inibidores de ciclooxigenase 2 Dor Revisão |
topic |
Anti-inflammatory agents Analgesia Cyclooxygenase 2 inhibitors Pain Review [publication type] Antiinflamatórios Analgesia Inibidores de ciclooxigenase 2 Dor Revisão |
description |
CONTEXT AND OBJECTIVE: Lumiracoxib is an anti-inflammatory drug that has been used to treat acute dental pain, mainly in postsurgical settings, in which the greatest levels of pain and discomfort are experienced during the first 24 hours. This study aimed to assess the efficacy and safety of lumiracoxib for treating acute postsurgical dental pain. DESIGN AND SETTING: Systematic review developed at the Brazilian Cochrane Centre, Universidade Federal de São Paulo (UNIFESP). METHODS: An electronic search was conducted in the PubMed, Cochrane Library, Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Embase databases. A manual search was also performed. Only randomized controlled trials were included, and these were selected and assessed by two researchers with regard to the risk of bias. RESULTS: Three clinical trials with 921 participants were included. Lumiracoxib 400 mg produced onset of analgesia in a shorter time than shown by lumiracoxib 100 mg, celecoxib 200 mg and ibuprofen 400 mg. There was no difference between lumiracoxib 400 mg and rofecoxib 50 mg. In two studies, the mean time taken to attain onset of analgesia for the placebo was not estimated because the number of participants who reached onset was too small. CONCLUSION: There is evidence with a moderate risk of bias that recommends the use of lumiracoxib for acute postoperative dental pain. However, the adverse effects are not completely known. Given that lumiracoxib is currently available in only three countries, further studies are likely to be rare and discouraged. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 2015-06-14T13:42:51Z 2015-06-14T13:42:51Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-31802011000500009 SILVA, Ricardo Carvalho Lopes; RIERA, Rachel; SACONATO, Humberto. Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials. Sao Paulo Med. J., São Paulo , v. 129, n. 5, p. 335-345, 2011 10.1590/S1516-31802011000500009 S1516-31802011000500009.pdf 1516-3180 S1516-31802011000500009 http://repositorio.unifesp.br/handle/11600/6241 WOS:000297807100009 |
url |
http://dx.doi.org/10.1590/S1516-31802011000500009 http://repositorio.unifesp.br/handle/11600/6241 |
identifier_str_mv |
SILVA, Ricardo Carvalho Lopes; RIERA, Rachel; SACONATO, Humberto. Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials. Sao Paulo Med. J., São Paulo , v. 129, n. 5, p. 335-345, 2011 10.1590/S1516-31802011000500009 S1516-31802011000500009.pdf 1516-3180 S1516-31802011000500009 WOS:000297807100009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
São Paulo Medical Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
335-345 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268370163335168 |