A new nomogram to predict pathologic outcome following radical prostatectomy
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1677-55382006000200005 http://repositorio.unifesp.br/handle/11600/2990 |
Resumo: | OBJECTIVE: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS AND METHODS: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. RESULTS: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. CONCLUSION: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer. |
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Repositório Institucional da UNIFESP |
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A new nomogram to predict pathologic outcome following radical prostatectomyprostatic neoplasmsneoplasm stagingnomogramsprostate-specific antigenneedle biopsyOBJECTIVE: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS AND METHODS: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. RESULTS: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. CONCLUSION: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer.Federal University of São Paulo Division of UrologyUNIFESP, Division of UrologySciELOSociedade Brasileira de UrologiaUniversidade Federal de São Paulo (UNIFESP)Crippa, Alexandre [UNIFESP]Srougi, Miguel [UNIFESP]Dall'Oglio, Marcos Francisco [UNIFESP]Antunes, Alberto A. [UNIFESP]Leite, Kátia Ramos Moreira [UNIFESP]Nesrallah, Luciano J. [UNIFESP]Ortiz, Valdemar [UNIFESP]2015-06-14T13:32:02Z2015-06-14T13:32:02Z2006-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion155-164application/pdfhttp://dx.doi.org/10.1590/S1677-55382006000200005International braz j urol. Sociedade Brasileira de Urologia, v. 32, n. 2, p. 155-164, 2006.10.1590/S1677-55382006000200005S1677-55382006000200005.pdf1677-5538S1677-55382006000200005http://repositorio.unifesp.br/handle/11600/2990engInternational braz j urolinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T10:28:31Zoai:repositorio.unifesp.br/:11600/2990Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T10:28:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
A new nomogram to predict pathologic outcome following radical prostatectomy |
title |
A new nomogram to predict pathologic outcome following radical prostatectomy |
spellingShingle |
A new nomogram to predict pathologic outcome following radical prostatectomy Crippa, Alexandre [UNIFESP] prostatic neoplasms neoplasm staging nomograms prostate-specific antigen needle biopsy |
title_short |
A new nomogram to predict pathologic outcome following radical prostatectomy |
title_full |
A new nomogram to predict pathologic outcome following radical prostatectomy |
title_fullStr |
A new nomogram to predict pathologic outcome following radical prostatectomy |
title_full_unstemmed |
A new nomogram to predict pathologic outcome following radical prostatectomy |
title_sort |
A new nomogram to predict pathologic outcome following radical prostatectomy |
author |
Crippa, Alexandre [UNIFESP] |
author_facet |
Crippa, Alexandre [UNIFESP] Srougi, Miguel [UNIFESP] Dall'Oglio, Marcos Francisco [UNIFESP] Antunes, Alberto A. [UNIFESP] Leite, Kátia Ramos Moreira [UNIFESP] Nesrallah, Luciano J. [UNIFESP] Ortiz, Valdemar [UNIFESP] |
author_role |
author |
author2 |
Srougi, Miguel [UNIFESP] Dall'Oglio, Marcos Francisco [UNIFESP] Antunes, Alberto A. [UNIFESP] Leite, Kátia Ramos Moreira [UNIFESP] Nesrallah, Luciano J. [UNIFESP] Ortiz, Valdemar [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Crippa, Alexandre [UNIFESP] Srougi, Miguel [UNIFESP] Dall'Oglio, Marcos Francisco [UNIFESP] Antunes, Alberto A. [UNIFESP] Leite, Kátia Ramos Moreira [UNIFESP] Nesrallah, Luciano J. [UNIFESP] Ortiz, Valdemar [UNIFESP] |
dc.subject.por.fl_str_mv |
prostatic neoplasms neoplasm staging nomograms prostate-specific antigen needle biopsy |
topic |
prostatic neoplasms neoplasm staging nomograms prostate-specific antigen needle biopsy |
description |
OBJECTIVE: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS AND METHODS: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. RESULTS: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. CONCLUSION: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-04-01 2015-06-14T13:32:02Z 2015-06-14T13:32:02Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1677-55382006000200005 International braz j urol. Sociedade Brasileira de Urologia, v. 32, n. 2, p. 155-164, 2006. 10.1590/S1677-55382006000200005 S1677-55382006000200005.pdf 1677-5538 S1677-55382006000200005 http://repositorio.unifesp.br/handle/11600/2990 |
url |
http://dx.doi.org/10.1590/S1677-55382006000200005 http://repositorio.unifesp.br/handle/11600/2990 |
identifier_str_mv |
International braz j urol. Sociedade Brasileira de Urologia, v. 32, n. 2, p. 155-164, 2006. 10.1590/S1677-55382006000200005 S1677-55382006000200005.pdf 1677-5538 S1677-55382006000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International braz j urol |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
155-164 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268300721389568 |