A new nomogram to predict pathologic outcome following radical prostatectomy

Detalhes bibliográficos
Autor(a) principal: Crippa, Alexandre [UNIFESP]
Data de Publicação: 2006
Outros Autores: Srougi, Miguel [UNIFESP], Dall'Oglio, Marcos Francisco [UNIFESP], Antunes, Alberto A. [UNIFESP], Leite, Kátia Ramos Moreira [UNIFESP], Nesrallah, Luciano J. [UNIFESP], Ortiz, Valdemar [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1677-55382006000200005
http://repositorio.unifesp.br/handle/11600/2990
Resumo: OBJECTIVE: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS AND METHODS: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. RESULTS: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. CONCLUSION: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer.
id UFSP_8695b9da16c1de0182839e82f28eb21a
oai_identifier_str oai:repositorio.unifesp.br/:11600/2990
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling A new nomogram to predict pathologic outcome following radical prostatectomyprostatic neoplasmsneoplasm stagingnomogramsprostate-specific antigenneedle biopsyOBJECTIVE: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS AND METHODS: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. RESULTS: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. CONCLUSION: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer.Federal University of São Paulo Division of UrologyUNIFESP, Division of UrologySciELOSociedade Brasileira de UrologiaUniversidade Federal de São Paulo (UNIFESP)Crippa, Alexandre [UNIFESP]Srougi, Miguel [UNIFESP]Dall'Oglio, Marcos Francisco [UNIFESP]Antunes, Alberto A. [UNIFESP]Leite, Kátia Ramos Moreira [UNIFESP]Nesrallah, Luciano J. [UNIFESP]Ortiz, Valdemar [UNIFESP]2015-06-14T13:32:02Z2015-06-14T13:32:02Z2006-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion155-164application/pdfhttp://dx.doi.org/10.1590/S1677-55382006000200005International braz j urol. Sociedade Brasileira de Urologia, v. 32, n. 2, p. 155-164, 2006.10.1590/S1677-55382006000200005S1677-55382006000200005.pdf1677-5538S1677-55382006000200005http://repositorio.unifesp.br/handle/11600/2990engInternational braz j urolinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T10:28:31Zoai:repositorio.unifesp.br/:11600/2990Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T10:28:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv A new nomogram to predict pathologic outcome following radical prostatectomy
title A new nomogram to predict pathologic outcome following radical prostatectomy
spellingShingle A new nomogram to predict pathologic outcome following radical prostatectomy
Crippa, Alexandre [UNIFESP]
prostatic neoplasms
neoplasm staging
nomograms
prostate-specific antigen
needle biopsy
title_short A new nomogram to predict pathologic outcome following radical prostatectomy
title_full A new nomogram to predict pathologic outcome following radical prostatectomy
title_fullStr A new nomogram to predict pathologic outcome following radical prostatectomy
title_full_unstemmed A new nomogram to predict pathologic outcome following radical prostatectomy
title_sort A new nomogram to predict pathologic outcome following radical prostatectomy
author Crippa, Alexandre [UNIFESP]
author_facet Crippa, Alexandre [UNIFESP]
Srougi, Miguel [UNIFESP]
Dall'Oglio, Marcos Francisco [UNIFESP]
Antunes, Alberto A. [UNIFESP]
Leite, Kátia Ramos Moreira [UNIFESP]
Nesrallah, Luciano J. [UNIFESP]
Ortiz, Valdemar [UNIFESP]
author_role author
author2 Srougi, Miguel [UNIFESP]
Dall'Oglio, Marcos Francisco [UNIFESP]
Antunes, Alberto A. [UNIFESP]
Leite, Kátia Ramos Moreira [UNIFESP]
Nesrallah, Luciano J. [UNIFESP]
Ortiz, Valdemar [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Crippa, Alexandre [UNIFESP]
Srougi, Miguel [UNIFESP]
Dall'Oglio, Marcos Francisco [UNIFESP]
Antunes, Alberto A. [UNIFESP]
Leite, Kátia Ramos Moreira [UNIFESP]
Nesrallah, Luciano J. [UNIFESP]
Ortiz, Valdemar [UNIFESP]
dc.subject.por.fl_str_mv prostatic neoplasms
neoplasm staging
nomograms
prostate-specific antigen
needle biopsy
topic prostatic neoplasms
neoplasm staging
nomograms
prostate-specific antigen
needle biopsy
description OBJECTIVE: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS AND METHODS: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. RESULTS: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. CONCLUSION: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer.
publishDate 2006
dc.date.none.fl_str_mv 2006-04-01
2015-06-14T13:32:02Z
2015-06-14T13:32:02Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1677-55382006000200005
International braz j urol. Sociedade Brasileira de Urologia, v. 32, n. 2, p. 155-164, 2006.
10.1590/S1677-55382006000200005
S1677-55382006000200005.pdf
1677-5538
S1677-55382006000200005
http://repositorio.unifesp.br/handle/11600/2990
url http://dx.doi.org/10.1590/S1677-55382006000200005
http://repositorio.unifesp.br/handle/11600/2990
identifier_str_mv International braz j urol. Sociedade Brasileira de Urologia, v. 32, n. 2, p. 155-164, 2006.
10.1590/S1677-55382006000200005
S1677-55382006000200005.pdf
1677-5538
S1677-55382006000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International braz j urol
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 155-164
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268300721389568