Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice

Detalhes bibliográficos
Autor(a) principal: Chinen, Cibele Cristina [UNIFESP]
Data de Publicação: 1999
Outros Autores: Frussa Filho, Roberto [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/S0893-133X(99)00061-5
http://repositorio.unifesp.br/handle/11600/26164
Resumo: The cataleptic behavior induced by the dopamine D-1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D-1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the repeated measures effect, a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D-2 antagonists. in this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D-1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This injection-conditioned catalepsy was also observed after repented treatment with the dopamine D-2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect. [Neuropsychopharmacology 21:670-678,1999] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
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spelling Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in micecatalepsy conditioningSCH 23390dopamine D-1 receptorplacebo effectrewardThe cataleptic behavior induced by the dopamine D-1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D-1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the repeated measures effect, a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D-2 antagonists. in this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D-1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This injection-conditioned catalepsy was also observed after repented treatment with the dopamine D-2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect. [Neuropsychopharmacology 21:670-678,1999] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.Universidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, BrazilWeb of ScienceElsevier B.V.Universidade Federal de São Paulo (UNIFESP)Chinen, Cibele Cristina [UNIFESP]Frussa Filho, Roberto [UNIFESP]2016-01-24T12:30:54Z2016-01-24T12:30:54Z1999-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion670-678http://dx.doi.org/10.1016/S0893-133X(99)00061-5Neuropsychopharmacology. New York: Elsevier B.V., v. 21, n. 5, p. 670-678, 1999.10.1016/S0893-133X(99)00061-50893-133Xhttp://repositorio.unifesp.br/handle/11600/26164WOS:000082807900008engNeuropsychopharmacologyinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T10:30:54Zoai:repositorio.unifesp.br/:11600/26164Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T10:30:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
title Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
spellingShingle Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
Chinen, Cibele Cristina [UNIFESP]
catalepsy conditioning
SCH 23390
dopamine D-1 receptor
placebo effect
reward
title_short Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
title_full Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
title_fullStr Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
title_full_unstemmed Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
title_sort Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
author Chinen, Cibele Cristina [UNIFESP]
author_facet Chinen, Cibele Cristina [UNIFESP]
Frussa Filho, Roberto [UNIFESP]
author_role author
author2 Frussa Filho, Roberto [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Chinen, Cibele Cristina [UNIFESP]
Frussa Filho, Roberto [UNIFESP]
dc.subject.por.fl_str_mv catalepsy conditioning
SCH 23390
dopamine D-1 receptor
placebo effect
reward
topic catalepsy conditioning
SCH 23390
dopamine D-1 receptor
placebo effect
reward
description The cataleptic behavior induced by the dopamine D-1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D-1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the repeated measures effect, a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D-2 antagonists. in this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D-1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This injection-conditioned catalepsy was also observed after repented treatment with the dopamine D-2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect. [Neuropsychopharmacology 21:670-678,1999] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
publishDate 1999
dc.date.none.fl_str_mv 1999-11-01
2016-01-24T12:30:54Z
2016-01-24T12:30:54Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/S0893-133X(99)00061-5
Neuropsychopharmacology. New York: Elsevier B.V., v. 21, n. 5, p. 670-678, 1999.
10.1016/S0893-133X(99)00061-5
0893-133X
http://repositorio.unifesp.br/handle/11600/26164
WOS:000082807900008
url http://dx.doi.org/10.1016/S0893-133X(99)00061-5
http://repositorio.unifesp.br/handle/11600/26164
identifier_str_mv Neuropsychopharmacology. New York: Elsevier B.V., v. 21, n. 5, p. 670-678, 1999.
10.1016/S0893-133X(99)00061-5
0893-133X
WOS:000082807900008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neuropsychopharmacology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 670-678
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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