Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1016/S0893-133X(99)00061-5 http://repositorio.unifesp.br/handle/11600/26164 |
Resumo: | The cataleptic behavior induced by the dopamine D-1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D-1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the repeated measures effect, a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D-2 antagonists. in this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D-1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This injection-conditioned catalepsy was also observed after repented treatment with the dopamine D-2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect. [Neuropsychopharmacology 21:670-678,1999] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. |
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Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in micecatalepsy conditioningSCH 23390dopamine D-1 receptorplacebo effectrewardThe cataleptic behavior induced by the dopamine D-1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D-1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the repeated measures effect, a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D-2 antagonists. in this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D-1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This injection-conditioned catalepsy was also observed after repented treatment with the dopamine D-2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect. [Neuropsychopharmacology 21:670-678,1999] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.Universidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, BrazilWeb of ScienceElsevier B.V.Universidade Federal de São Paulo (UNIFESP)Chinen, Cibele Cristina [UNIFESP]Frussa Filho, Roberto [UNIFESP]2016-01-24T12:30:54Z2016-01-24T12:30:54Z1999-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion670-678http://dx.doi.org/10.1016/S0893-133X(99)00061-5Neuropsychopharmacology. New York: Elsevier B.V., v. 21, n. 5, p. 670-678, 1999.10.1016/S0893-133X(99)00061-50893-133Xhttp://repositorio.unifesp.br/handle/11600/26164WOS:000082807900008engNeuropsychopharmacologyinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T10:30:54Zoai:repositorio.unifesp.br/:11600/26164Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T10:30:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice |
title |
Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice |
spellingShingle |
Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice Chinen, Cibele Cristina [UNIFESP] catalepsy conditioning SCH 23390 dopamine D-1 receptor placebo effect reward |
title_short |
Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice |
title_full |
Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice |
title_fullStr |
Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice |
title_full_unstemmed |
Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice |
title_sort |
Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice |
author |
Chinen, Cibele Cristina [UNIFESP] |
author_facet |
Chinen, Cibele Cristina [UNIFESP] Frussa Filho, Roberto [UNIFESP] |
author_role |
author |
author2 |
Frussa Filho, Roberto [UNIFESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Chinen, Cibele Cristina [UNIFESP] Frussa Filho, Roberto [UNIFESP] |
dc.subject.por.fl_str_mv |
catalepsy conditioning SCH 23390 dopamine D-1 receptor placebo effect reward |
topic |
catalepsy conditioning SCH 23390 dopamine D-1 receptor placebo effect reward |
description |
The cataleptic behavior induced by the dopamine D-1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D-1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the repeated measures effect, a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D-2 antagonists. in this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D-1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This injection-conditioned catalepsy was also observed after repented treatment with the dopamine D-2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect. [Neuropsychopharmacology 21:670-678,1999] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-11-01 2016-01-24T12:30:54Z 2016-01-24T12:30:54Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/S0893-133X(99)00061-5 Neuropsychopharmacology. New York: Elsevier B.V., v. 21, n. 5, p. 670-678, 1999. 10.1016/S0893-133X(99)00061-5 0893-133X http://repositorio.unifesp.br/handle/11600/26164 WOS:000082807900008 |
url |
http://dx.doi.org/10.1016/S0893-133X(99)00061-5 http://repositorio.unifesp.br/handle/11600/26164 |
identifier_str_mv |
Neuropsychopharmacology. New York: Elsevier B.V., v. 21, n. 5, p. 670-678, 1999. 10.1016/S0893-133X(99)00061-5 0893-133X WOS:000082807900008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neuropsychopharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
dc.format.none.fl_str_mv |
670-678 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268435601817600 |