Pathological extension of prostate cancer as defined by gleason score on biopsy
Autor(a) principal: | |
---|---|
Data de Publicação: | 2005 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/2608 http://dx.doi.org/10.1590/S1677-55382005000400005 |
Resumo: | INTRODUCTION: Based on the importance of the Gleason score on the behavior of prostate adenocarcinoma, this study attempts to predict the extension of prostate adenocarcinoma pre-operatively, as defined by the Gleason score on biopsy, in individuals who will undergo radical prostatectomy. MATERIALS AND METHODS: We selected 899 individuals who underwent retropubic radical prostatectomy from 1988 to 2004. Clinical and pathological data obtained in the preoperative period were retrospectively analyzed through digital rectal examinations of the prostate, initial serum PSA levels and pathological data provided by biopsy. The Gleason score on biopsy was assessed and divided into 3 groups: 2 to 6, 7, and 8 to 10, and correlated with the possibility of the disease being confined to the prostate. RESULTS: From the 899 selected patients, 654 (74%) showed Gleason scores of 2 to 6, 165 (18%) had a score of 7 and 80 (9%) had scores of 8 to 10 on biopsy. The likelihood of confined diseases, extraprostatic extensions, invasion of seminal vesicles and lymph nodal involvement were respectively: 74%, 18%, 8% and 0.8% for a Gleason score of 2 to 6, 47%, 30%, 19% and 4% for a Gleason score of 7, and 49%, 29%, 18% and 4% for a Gleason score of 8 to 10. CONCLUSION: In patients who will undergo radical prostatectomy due to prostate adenocarcinoma, a Gleason score of 7 on biopsy shows the same behavior as a Gleason score of 8 to 10 in relation to extension of disease. |
id |
UFSP_87ffc577073c21481d9da564283a817d |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/2608 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Dall'Oglio, Marcos Francisco [UNIFESP]Crippa, Alexandre [UNIFESP]Paranhos, Mario [UNIFESP]Nesrallah, Luciano J. [UNIFESP]Leite, Kátia Ramos Moreira [UNIFESP]Srougi, Miguel [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:31:40Z2015-06-14T13:31:40Z2005-08-01International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 4, p. 326-330, 2005.1677-5538http://repositorio.unifesp.br/handle/11600/2608http://dx.doi.org/10.1590/S1677-55382005000400005S1677-55382005000400005.pdfS1677-5538200500040000510.1590/S1677-55382005000400005INTRODUCTION: Based on the importance of the Gleason score on the behavior of prostate adenocarcinoma, this study attempts to predict the extension of prostate adenocarcinoma pre-operatively, as defined by the Gleason score on biopsy, in individuals who will undergo radical prostatectomy. MATERIALS AND METHODS: We selected 899 individuals who underwent retropubic radical prostatectomy from 1988 to 2004. Clinical and pathological data obtained in the preoperative period were retrospectively analyzed through digital rectal examinations of the prostate, initial serum PSA levels and pathological data provided by biopsy. The Gleason score on biopsy was assessed and divided into 3 groups: 2 to 6, 7, and 8 to 10, and correlated with the possibility of the disease being confined to the prostate. RESULTS: From the 899 selected patients, 654 (74%) showed Gleason scores of 2 to 6, 165 (18%) had a score of 7 and 80 (9%) had scores of 8 to 10 on biopsy. The likelihood of confined diseases, extraprostatic extensions, invasion of seminal vesicles and lymph nodal involvement were respectively: 74%, 18%, 8% and 0.8% for a Gleason score of 2 to 6, 47%, 30%, 19% and 4% for a Gleason score of 7, and 49%, 29%, 18% and 4% for a Gleason score of 8 to 10. CONCLUSION: In patients who will undergo radical prostatectomy due to prostate adenocarcinoma, a Gleason score of 7 on biopsy shows the same behavior as a Gleason score of 8 to 10 in relation to extension of disease.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Division of UrologyUNIFESP, EPM, Division of UrologySciELO326-330engSociedade Brasileira de UrologiaInternational braz j urolprostatic neoplasmsneoplasm stagingbiopsyneedlepathologyPathological extension of prostate cancer as defined by gleason score on biopsyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1677-55382005000400005.pdfapplication/pdf21192${dspace.ui.url}/bitstream/11600/2608/1/S1677-55382005000400005.pdfdcb490357ae29a63162c928ebc6d80b6MD51open accessTEXTS1677-55382005000400005.pdf.txtS1677-55382005000400005.pdf.txtExtracted texttext/plain18239${dspace.ui.url}/bitstream/11600/2608/2/S1677-55382005000400005.pdf.txtfa5e2b3fb8c6e131c531daa1cc2274e3MD52open access11600/26082022-11-04 15:40:35.39open accessoai:repositorio.unifesp.br:11600/2608Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-11-04T18:40:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Pathological extension of prostate cancer as defined by gleason score on biopsy |
title |
Pathological extension of prostate cancer as defined by gleason score on biopsy |
spellingShingle |
Pathological extension of prostate cancer as defined by gleason score on biopsy Dall'Oglio, Marcos Francisco [UNIFESP] prostatic neoplasms neoplasm staging biopsy needle pathology |
title_short |
Pathological extension of prostate cancer as defined by gleason score on biopsy |
title_full |
Pathological extension of prostate cancer as defined by gleason score on biopsy |
title_fullStr |
Pathological extension of prostate cancer as defined by gleason score on biopsy |
title_full_unstemmed |
Pathological extension of prostate cancer as defined by gleason score on biopsy |
title_sort |
Pathological extension of prostate cancer as defined by gleason score on biopsy |
author |
Dall'Oglio, Marcos Francisco [UNIFESP] |
author_facet |
Dall'Oglio, Marcos Francisco [UNIFESP] Crippa, Alexandre [UNIFESP] Paranhos, Mario [UNIFESP] Nesrallah, Luciano J. [UNIFESP] Leite, Kátia Ramos Moreira [UNIFESP] Srougi, Miguel [UNIFESP] |
author_role |
author |
author2 |
Crippa, Alexandre [UNIFESP] Paranhos, Mario [UNIFESP] Nesrallah, Luciano J. [UNIFESP] Leite, Kátia Ramos Moreira [UNIFESP] Srougi, Miguel [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Dall'Oglio, Marcos Francisco [UNIFESP] Crippa, Alexandre [UNIFESP] Paranhos, Mario [UNIFESP] Nesrallah, Luciano J. [UNIFESP] Leite, Kátia Ramos Moreira [UNIFESP] Srougi, Miguel [UNIFESP] |
dc.subject.eng.fl_str_mv |
prostatic neoplasms neoplasm staging biopsy needle pathology |
topic |
prostatic neoplasms neoplasm staging biopsy needle pathology |
description |
INTRODUCTION: Based on the importance of the Gleason score on the behavior of prostate adenocarcinoma, this study attempts to predict the extension of prostate adenocarcinoma pre-operatively, as defined by the Gleason score on biopsy, in individuals who will undergo radical prostatectomy. MATERIALS AND METHODS: We selected 899 individuals who underwent retropubic radical prostatectomy from 1988 to 2004. Clinical and pathological data obtained in the preoperative period were retrospectively analyzed through digital rectal examinations of the prostate, initial serum PSA levels and pathological data provided by biopsy. The Gleason score on biopsy was assessed and divided into 3 groups: 2 to 6, 7, and 8 to 10, and correlated with the possibility of the disease being confined to the prostate. RESULTS: From the 899 selected patients, 654 (74%) showed Gleason scores of 2 to 6, 165 (18%) had a score of 7 and 80 (9%) had scores of 8 to 10 on biopsy. The likelihood of confined diseases, extraprostatic extensions, invasion of seminal vesicles and lymph nodal involvement were respectively: 74%, 18%, 8% and 0.8% for a Gleason score of 2 to 6, 47%, 30%, 19% and 4% for a Gleason score of 7, and 49%, 29%, 18% and 4% for a Gleason score of 8 to 10. CONCLUSION: In patients who will undergo radical prostatectomy due to prostate adenocarcinoma, a Gleason score of 7 on biopsy shows the same behavior as a Gleason score of 8 to 10 in relation to extension of disease. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-08-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:31:40Z |
dc.date.available.fl_str_mv |
2015-06-14T13:31:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 4, p. 326-330, 2005. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/2608 http://dx.doi.org/10.1590/S1677-55382005000400005 |
dc.identifier.issn.none.fl_str_mv |
1677-5538 |
dc.identifier.file.none.fl_str_mv |
S1677-55382005000400005.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1677-55382005000400005 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1677-55382005000400005 |
identifier_str_mv |
International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 4, p. 326-330, 2005. 1677-5538 S1677-55382005000400005.pdf S1677-55382005000400005 10.1590/S1677-55382005000400005 |
url |
http://repositorio.unifesp.br/handle/11600/2608 http://dx.doi.org/10.1590/S1677-55382005000400005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
International braz j urol |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
326-330 |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/2608/1/S1677-55382005000400005.pdf ${dspace.ui.url}/bitstream/11600/2608/2/S1677-55382005000400005.pdf.txt |
bitstream.checksum.fl_str_mv |
dcb490357ae29a63162c928ebc6d80b6 fa5e2b3fb8c6e131c531daa1cc2274e3 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764187822194688 |