Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

• Autor(a) principal: Siqueira, Lilian [UNIFESP]
• Data de Publicação: 2017
• Outros Autores: de Paula, Cynthia Guimaraes [UNIFESP], Motisuke, Mariana [UNIFESP], Gouveia, Rubia Figueredo, Afonso Camargo, Samira Esteves, Moreira Milhan, Noala Vicensoto, Triches, Eliandra de Sousa [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/1980-5373-MR-2016-0467; https://repositorio.unifesp.br/handle/11600/53521
• topic: Tricalcium phosphate; alumina; gel-casting method; cytocompatibility; scaffolds

Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. beta-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, beta-TCP and beta-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (8688%) and pore sizes ranging from 200 to 500 mu m. Even though alumina did not promote improvement in beta-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, beta-TCP and beta-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.