Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/1465 http://dx.doi.org/10.1590/S0100-879X2002000600015 |
Resumo: | Despite its ancient use as a therapeutic tool to treat several ailments, acupuncture still faces the challenge of scrutiny by Western science both in terms of its efficacy and in terms of the characterization of its effects and mechanisms of actions underlying these effects. We investigated under well-controlled and carefully characterized conditions the influence of electrical stimulation of acupuncture points ST-36 (Zusanli) and SP-6 (Sanyinjiao) on the myoelectric activity of the small intestine of 38 adult male Wistar rats. Electrical recordings obtained by means of four electrodes chronically implanted in the small intestine were used to assess the effects of acupuncture (electroacupuncture stimulation set at 2 Hz, intermittent stimulation, 1 V, for 30 min). Immobilization of the animals was associated with a consistent decrease (-8 ± 7%) in the myoelectric activity of the small intestine as measured by means of the root mean square. Conversely, acupuncture was able to significantly increase (overshoot) this activity compared to baseline (+44 ± 7%). In contrast, immobilized animals subjected to sham acupuncture had only modest (nonsignificant) increases in myoelectric activity (+9 ± 6%). Using carefully controlled conditions we confirmed previous noncontrolled studies on the ability of acupuncture to alter intestinal motility. The characterization of the topographic and temporal profiles of the effects observed here represents a basis for future dissection of the physiological and pharmacological systems underlying these effects. |
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Tabosa, Angela Maria Florencio [UNIFESP]Yamamura, Ysao [UNIFESP]Forno, E.r. [UNIFESP]Mello, Luiz Eugenio Araujo de Moraes [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:29:44Z2015-06-14T13:29:44Z2002-06-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 6, p. 731-739, 2002.0100-879Xhttp://repositorio.unifesp.br/handle/11600/1465http://dx.doi.org/10.1590/S0100-879X2002000600015S0100-879X2002000600015.pdfS0100-879X200200060001510.1590/S0100-879X2002000600015WOS:000176452400015Despite its ancient use as a therapeutic tool to treat several ailments, acupuncture still faces the challenge of scrutiny by Western science both in terms of its efficacy and in terms of the characterization of its effects and mechanisms of actions underlying these effects. We investigated under well-controlled and carefully characterized conditions the influence of electrical stimulation of acupuncture points ST-36 (Zusanli) and SP-6 (Sanyinjiao) on the myoelectric activity of the small intestine of 38 adult male Wistar rats. Electrical recordings obtained by means of four electrodes chronically implanted in the small intestine were used to assess the effects of acupuncture (electroacupuncture stimulation set at 2 Hz, intermittent stimulation, 1 V, for 30 min). Immobilization of the animals was associated with a consistent decrease (-8 ± 7%) in the myoelectric activity of the small intestine as measured by means of the root mean square. Conversely, acupuncture was able to significantly increase (overshoot) this activity compared to baseline (+44 ± 7%). In contrast, immobilized animals subjected to sham acupuncture had only modest (nonsignificant) increases in myoelectric activity (+9 ± 6%). Using carefully controlled conditions we confirmed previous noncontrolled studies on the ability of acupuncture to alter intestinal motility. The characterization of the topographic and temporal profiles of the effects observed here represents a basis for future dissection of the physiological and pharmacological systems underlying these effects.Universidade Federal de São Paulo (UNIFESP) Departamento de Ortopedia e Traumatologia Divisão de Medicina Chinesa e AcupunturaUniversidade Federal de São Paulo (UNIFESP) Departamento de FisiologiaUNIFESP, Depto. de Ortopedia e Traumatologia Divisão de Medicina Chinesa e AcupunturaUNIFESP, Depto. de FisiologiaSciELO731-739engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchAcupunctureIntestinal motilityRatMyoelectric activityAcupuncture pointEffect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2002000600015.pdfapplication/pdf474843${dspace.ui.url}/bitstream/11600/1465/1/S0100-879X2002000600015.pdfea591f409530c1bf25bd43d1735417b6MD51open accessTEXTS0100-879X2002000600015.pdf.txtS0100-879X2002000600015.pdf.txtExtracted texttext/plain35678${dspace.ui.url}/bitstream/11600/1465/21/S0100-879X2002000600015.pdf.txt474c79e0949b3c58225dd421bc78fc5aMD521open accessTHUMBNAILS0100-879X2002000600015.pdf.jpgS0100-879X2002000600015.pdf.jpgIM Thumbnailimage/jpeg5585${dspace.ui.url}/bitstream/11600/1465/23/S0100-879X2002000600015.pdf.jpgc40a6a89e6726a7c1efa608826addcb7MD523open access11600/14652023-06-05 19:40:42.829open accessoai:repositorio.unifesp.br:11600/1465Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:40:42Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats |
title |
Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats |
spellingShingle |
Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats Tabosa, Angela Maria Florencio [UNIFESP] Acupuncture Intestinal motility Rat Myoelectric activity Acupuncture point |
title_short |
Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats |
title_full |
Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats |
title_fullStr |
Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats |
title_full_unstemmed |
Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats |
title_sort |
Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats |
author |
Tabosa, Angela Maria Florencio [UNIFESP] |
author_facet |
Tabosa, Angela Maria Florencio [UNIFESP] Yamamura, Ysao [UNIFESP] Forno, E.r. [UNIFESP] Mello, Luiz Eugenio Araujo de Moraes [UNIFESP] |
author_role |
author |
author2 |
Yamamura, Ysao [UNIFESP] Forno, E.r. [UNIFESP] Mello, Luiz Eugenio Araujo de Moraes [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Tabosa, Angela Maria Florencio [UNIFESP] Yamamura, Ysao [UNIFESP] Forno, E.r. [UNIFESP] Mello, Luiz Eugenio Araujo de Moraes [UNIFESP] |
dc.subject.eng.fl_str_mv |
Acupuncture Intestinal motility Rat Myoelectric activity Acupuncture point |
topic |
Acupuncture Intestinal motility Rat Myoelectric activity Acupuncture point |
description |
Despite its ancient use as a therapeutic tool to treat several ailments, acupuncture still faces the challenge of scrutiny by Western science both in terms of its efficacy and in terms of the characterization of its effects and mechanisms of actions underlying these effects. We investigated under well-controlled and carefully characterized conditions the influence of electrical stimulation of acupuncture points ST-36 (Zusanli) and SP-6 (Sanyinjiao) on the myoelectric activity of the small intestine of 38 adult male Wistar rats. Electrical recordings obtained by means of four electrodes chronically implanted in the small intestine were used to assess the effects of acupuncture (electroacupuncture stimulation set at 2 Hz, intermittent stimulation, 1 V, for 30 min). Immobilization of the animals was associated with a consistent decrease (-8 ± 7%) in the myoelectric activity of the small intestine as measured by means of the root mean square. Conversely, acupuncture was able to significantly increase (overshoot) this activity compared to baseline (+44 ± 7%). In contrast, immobilized animals subjected to sham acupuncture had only modest (nonsignificant) increases in myoelectric activity (+9 ± 6%). Using carefully controlled conditions we confirmed previous noncontrolled studies on the ability of acupuncture to alter intestinal motility. The characterization of the topographic and temporal profiles of the effects observed here represents a basis for future dissection of the physiological and pharmacological systems underlying these effects. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002-06-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:29:44Z |
dc.date.available.fl_str_mv |
2015-06-14T13:29:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 6, p. 731-739, 2002. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/1465 http://dx.doi.org/10.1590/S0100-879X2002000600015 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2002000600015.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2002000600015 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2002000600015 |
dc.identifier.wos.none.fl_str_mv |
WOS:000176452400015 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 6, p. 731-739, 2002. 0100-879X S0100-879X2002000600015.pdf S0100-879X2002000600015 10.1590/S0100-879X2002000600015 WOS:000176452400015 |
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http://repositorio.unifesp.br/handle/11600/1465 http://dx.doi.org/10.1590/S0100-879X2002000600015 |
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Brazilian Journal of Medical and Biological Research |
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Associação Brasileira de Divulgação Científica |
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