Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado

Detalhes bibliográficos
Autor(a) principal: Wandalsen, Gustavo F. [UNIFESP]
Data de Publicação: 2017
Outros Autores: Miranda, Carolina [UNIFESP], Ensina, Luis Felipe [UNIFESP], Sano, Flavio, Amazonas, Roberto Bleul, da Silva, Joyce Macedo, Sole, Dirceu [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.bjorl.2016.08.009
https://repositorio.unifesp.br/handle/11600/58242
Resumo: Introduction: A combination of antihistamines and oral corticosteroids is often used to treat acute symptoms of allergic rhinitis. Objective: To evaluate safety and efficacy of desloratadine plus prednisolone in the treatment of acute symptoms of children (2-12 years) with allergic rhinitis, and to compare it to dexchlorpheniramine plus betamethasone. Methods: Children with moderate/severe persistent allergic rhinitis and symptomatic (nasal symptoms score [0-12] >= 6) were allocated in a double-blind, randomized fashion to receive dexchlorpheniramine plus betamethasone (n = 105; three daily doses) or desloratadine plus prednisolone (n = 105; single dose followed by two of placebo) for 7 days. At the beginning and end of the evaluation, the following were obtained: nasal symptoms score, extra nasal symptoms score, peak nasal inspiratory flow, blood biochemistry, and electrocardiogram. Ninety-six children of the dexchlorpheniramine plus betamethasone group and 98 of the desloratadine plus prednisolone group completed the protocol. Results: The two groups were similar regarding initial and final nasal symptoms scores, extra nasal symptoms scores and peak nasal inspiratory flow. A drop of 76.4% and 79.1% for nasal symptoms score, 86.0% and 79.2% for extra nasal symptoms score, as well as an increase of 25.2% and 24.3% for peak nasal inspiratory flow occurred for those treated with desloratadine plus prednisolone and dexchlorpheniramine plus betamethasone, respectively. There were no significant changes in blood chemistry. Sinus tachycardia was the most frequent electrocardiogram change, but with no clinical significance. Drowsiness was reported significantly more often among those of dexchlorpheniramine plus betamethasone group (17.14% x 8.57%, respectively). Conclusion: The desloratadine plus prednisolone combination was able to effectively control acute symptoms of rhinitis in children, improving symptoms and nasal function. Compared to the dexchlorpheniramine plus betamethasone combination, it showed similar clinical action, but with a lower incidence of adverse events and higher dosing convenience. (C) 2016 Published by Elsevier Editora Ltda. on behalf of Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.
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spelling Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controladoAssociation between desloratadine and prednisolone in the treatment of children with acute symptoms of allergic rhinitis: a double-blind, randomized and controlled clinical trialAllergic rhinitisDesloratadineDexchlorpheniraminePrednisoloneBetamethasoneRinite alérgicaDesloratadinaDexclorfeniraminaPrednisolonaBetametasonaIntroduction: A combination of antihistamines and oral corticosteroids is often used to treat acute symptoms of allergic rhinitis. Objective: To evaluate safety and efficacy of desloratadine plus prednisolone in the treatment of acute symptoms of children (2-12 years) with allergic rhinitis, and to compare it to dexchlorpheniramine plus betamethasone. Methods: Children with moderate/severe persistent allergic rhinitis and symptomatic (nasal symptoms score [0-12] >= 6) were allocated in a double-blind, randomized fashion to receive dexchlorpheniramine plus betamethasone (n = 105; three daily doses) or desloratadine plus prednisolone (n = 105; single dose followed by two of placebo) for 7 days. At the beginning and end of the evaluation, the following were obtained: nasal symptoms score, extra nasal symptoms score, peak nasal inspiratory flow, blood biochemistry, and electrocardiogram. Ninety-six children of the dexchlorpheniramine plus betamethasone group and 98 of the desloratadine plus prednisolone group completed the protocol. Results: The two groups were similar regarding initial and final nasal symptoms scores, extra nasal symptoms scores and peak nasal inspiratory flow. A drop of 76.4% and 79.1% for nasal symptoms score, 86.0% and 79.2% for extra nasal symptoms score, as well as an increase of 25.2% and 24.3% for peak nasal inspiratory flow occurred for those treated with desloratadine plus prednisolone and dexchlorpheniramine plus betamethasone, respectively. There were no significant changes in blood chemistry. Sinus tachycardia was the most frequent electrocardiogram change, but with no clinical significance. Drowsiness was reported significantly more often among those of dexchlorpheniramine plus betamethasone group (17.14% x 8.57%, respectively). Conclusion: The desloratadine plus prednisolone combination was able to effectively control acute symptoms of rhinitis in children, improving symptoms and nasal function. Compared to the dexchlorpheniramine plus betamethasone combination, it showed similar clinical action, but with a lower incidence of adverse events and higher dosing convenience. (C) 2016 Published by Elsevier Editora Ltda. on behalf of Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.Univ Fed Sao Paulo Unifesp, EPM, Dept Pediat, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, EPM, Dept Ginecol, Sao Paulo, SP, BrazilFundacao Apoio Escola Paulista Med FAP, Sao Paulo, SP, BrazilUniv Santo Amaro Unisa, Clin Med, Sao Paulo, SP, BrazilHosp Nipo Brasileiro, Pediat, Sao Paulo, SP, BrazilUniv Estadual Campinas Unicamp, Campinas, SP, BrazilFundacao Getulio Vargas, Mkt, Rio De Janeiro, RJ, BrazilGrp NC Farma, Sao Paulo, SP, BrazilGrp NC Farma, Pesquisa Clin & Farmacovigilancia, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, EPM, Dept Pediat, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, EPM, Dept Ginecol, Sao Paulo, SP, BrazilFundacao Apoio Escola Paulista Med FAP, Sao Paulo, SP, BrazilWeb of ScienceFunding authority for Studies and Projects (FINEP) - Innovation and Research, BrazilEMS/AS - Sao Paulo, BrazilEMS/AS - Sao Paulo, Brazil: 01.12.0094.00EMS/AS - Sao Paulo, Brazil: FINEP-1375/10Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial2020-09-01T13:21:25Z2020-09-01T13:21:25Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion633-639application/pdfapplication/pdfhttp://dx.doi.org/10.1016/j.bjorl.2016.08.009Brazilian Journal Of Otorhinolaryngology. Sao Paulo, v. 83, n. 6, p. 633-639, 2017.10.1016/j.bjorl.2016.08.009S1808-86942017000600633-en.pdfS1808-86942017000600633-pt.pdf1808-8694S1808-86942017000600633https://repositorio.unifesp.br/handle/11600/58242WOS:000417392200005engporBrazilian Journal Of OtorhinolaryngologySao Pauloinfo:eu-repo/semantics/openAccessWandalsen, Gustavo F. [UNIFESP]Miranda, Carolina [UNIFESP]Ensina, Luis Felipe [UNIFESP]Sano, FlavioAmazonas, Roberto Bleulda Silva, Joyce MacedoSole, Dirceu [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-02T00:58:04Zoai:repositorio.unifesp.br/:11600/58242Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-02T00:58:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado
Association between desloratadine and prednisolone in the treatment of children with acute symptoms of allergic rhinitis: a double-blind, randomized and controlled clinical trial
title Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado
spellingShingle Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado
Wandalsen, Gustavo F. [UNIFESP]
Allergic rhinitis
Desloratadine
Dexchlorpheniramine
Prednisolone
Betamethasone
Rinite alérgica
Desloratadina
Dexclorfeniramina
Prednisolona
Betametasona
title_short Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado
title_full Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado
title_fullStr Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado
title_full_unstemmed Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado
title_sort Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado
author Wandalsen, Gustavo F. [UNIFESP]
author_facet Wandalsen, Gustavo F. [UNIFESP]
Miranda, Carolina [UNIFESP]
Ensina, Luis Felipe [UNIFESP]
Sano, Flavio
Amazonas, Roberto Bleul
da Silva, Joyce Macedo
Sole, Dirceu [UNIFESP]
author_role author
author2 Miranda, Carolina [UNIFESP]
Ensina, Luis Felipe [UNIFESP]
Sano, Flavio
Amazonas, Roberto Bleul
da Silva, Joyce Macedo
Sole, Dirceu [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wandalsen, Gustavo F. [UNIFESP]
Miranda, Carolina [UNIFESP]
Ensina, Luis Felipe [UNIFESP]
Sano, Flavio
Amazonas, Roberto Bleul
da Silva, Joyce Macedo
Sole, Dirceu [UNIFESP]
dc.subject.por.fl_str_mv Allergic rhinitis
Desloratadine
Dexchlorpheniramine
Prednisolone
Betamethasone
Rinite alérgica
Desloratadina
Dexclorfeniramina
Prednisolona
Betametasona
topic Allergic rhinitis
Desloratadine
Dexchlorpheniramine
Prednisolone
Betamethasone
Rinite alérgica
Desloratadina
Dexclorfeniramina
Prednisolona
Betametasona
description Introduction: A combination of antihistamines and oral corticosteroids is often used to treat acute symptoms of allergic rhinitis. Objective: To evaluate safety and efficacy of desloratadine plus prednisolone in the treatment of acute symptoms of children (2-12 years) with allergic rhinitis, and to compare it to dexchlorpheniramine plus betamethasone. Methods: Children with moderate/severe persistent allergic rhinitis and symptomatic (nasal symptoms score [0-12] >= 6) were allocated in a double-blind, randomized fashion to receive dexchlorpheniramine plus betamethasone (n = 105; three daily doses) or desloratadine plus prednisolone (n = 105; single dose followed by two of placebo) for 7 days. At the beginning and end of the evaluation, the following were obtained: nasal symptoms score, extra nasal symptoms score, peak nasal inspiratory flow, blood biochemistry, and electrocardiogram. Ninety-six children of the dexchlorpheniramine plus betamethasone group and 98 of the desloratadine plus prednisolone group completed the protocol. Results: The two groups were similar regarding initial and final nasal symptoms scores, extra nasal symptoms scores and peak nasal inspiratory flow. A drop of 76.4% and 79.1% for nasal symptoms score, 86.0% and 79.2% for extra nasal symptoms score, as well as an increase of 25.2% and 24.3% for peak nasal inspiratory flow occurred for those treated with desloratadine plus prednisolone and dexchlorpheniramine plus betamethasone, respectively. There were no significant changes in blood chemistry. Sinus tachycardia was the most frequent electrocardiogram change, but with no clinical significance. Drowsiness was reported significantly more often among those of dexchlorpheniramine plus betamethasone group (17.14% x 8.57%, respectively). Conclusion: The desloratadine plus prednisolone combination was able to effectively control acute symptoms of rhinitis in children, improving symptoms and nasal function. Compared to the dexchlorpheniramine plus betamethasone combination, it showed similar clinical action, but with a lower incidence of adverse events and higher dosing convenience. (C) 2016 Published by Elsevier Editora Ltda. on behalf of Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-09-01T13:21:25Z
2020-09-01T13:21:25Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.bjorl.2016.08.009
Brazilian Journal Of Otorhinolaryngology. Sao Paulo, v. 83, n. 6, p. 633-639, 2017.
10.1016/j.bjorl.2016.08.009
S1808-86942017000600633-en.pdf
S1808-86942017000600633-pt.pdf
1808-8694
S1808-86942017000600633
https://repositorio.unifesp.br/handle/11600/58242
WOS:000417392200005
url http://dx.doi.org/10.1016/j.bjorl.2016.08.009
https://repositorio.unifesp.br/handle/11600/58242
identifier_str_mv Brazilian Journal Of Otorhinolaryngology. Sao Paulo, v. 83, n. 6, p. 633-639, 2017.
10.1016/j.bjorl.2016.08.009
S1808-86942017000600633-en.pdf
S1808-86942017000600633-pt.pdf
1808-8694
S1808-86942017000600633
WOS:000417392200005
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv Brazilian Journal Of Otorhinolaryngology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 633-639
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Sao Paulo
dc.publisher.none.fl_str_mv Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
publisher.none.fl_str_mv Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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